A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome

A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome

Keiji Kawatani et al. developed a panel of Down syndrome (DS) isogenic astrocytes derived from iPSCs to observe the consequence of DS on astrocyte precursor proliferation, differentiation, and gene expression. Their results suggest a dose-dependent effect of DYRK1A and PIGP on DS-derived astrocyte p...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Keiji Kawatani, Toshihiko Nambara, Nobutoshi Nawa, Hidetaka Yoshimatsu, Haruna Kusakabe, Katsuya Hirata, Akira Tanave, Kenta Sumiyama, Kimihiko Banno, Hidetoshi Taniguchi, Hitomi Arahori, Keiichi Ozono, Yasuji Kitabatake
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/e91008f5d0604ea7bd9c6ba4cad7e588
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:e91008f5d0604ea7bd9c6ba4cad7e588
record_format dspace
spelling oai:doaj.org-article:e91008f5d0604ea7bd9c6ba4cad7e5882021-12-02T17:39:49ZA human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome10.1038/s42003-021-02242-72399-3642https://doaj.org/article/e91008f5d0604ea7bd9c6ba4cad7e5882021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02242-7https://doaj.org/toc/2399-3642Keiji Kawatani et al. developed a panel of Down syndrome (DS) isogenic astrocytes derived from iPSCs to observe the consequence of DS on astrocyte precursor proliferation, differentiation, and gene expression. Their results suggest a dose-dependent effect of DYRK1A and PIGP on DS-derived astrocyte precursor proliferation, and represent a valuable resource and cellular model for future DS research.Keiji KawataniToshihiko NambaraNobutoshi NawaHidetaka YoshimatsuHaruna KusakabeKatsuya HirataAkira TanaveKenta SumiyamaKimihiko BannoHidetoshi TaniguchiHitomi ArahoriKeiichi OzonoYasuji KitabatakeNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Keiji Kawatani
Toshihiko Nambara
Nobutoshi Nawa
Hidetaka Yoshimatsu
Haruna Kusakabe
Katsuya Hirata
Akira Tanave
Kenta Sumiyama
Kimihiko Banno
Hidetoshi Taniguchi
Hitomi Arahori
Keiichi Ozono
Yasuji Kitabatake
A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome
description Keiji Kawatani et al. developed a panel of Down syndrome (DS) isogenic astrocytes derived from iPSCs to observe the consequence of DS on astrocyte precursor proliferation, differentiation, and gene expression. Their results suggest a dose-dependent effect of DYRK1A and PIGP on DS-derived astrocyte precursor proliferation, and represent a valuable resource and cellular model for future DS research.
format article
author Keiji Kawatani
Toshihiko Nambara
Nobutoshi Nawa
Hidetaka Yoshimatsu
Haruna Kusakabe
Katsuya Hirata
Akira Tanave
Kenta Sumiyama
Kimihiko Banno
Hidetoshi Taniguchi
Hitomi Arahori
Keiichi Ozono
Yasuji Kitabatake
author_facet Keiji Kawatani
Toshihiko Nambara
Nobutoshi Nawa
Hidetaka Yoshimatsu
Haruna Kusakabe
Katsuya Hirata
Akira Tanave
Kenta Sumiyama
Kimihiko Banno
Hidetoshi Taniguchi
Hitomi Arahori
Keiichi Ozono
Yasuji Kitabatake
author_sort Keiji Kawatani
title A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome
title_short A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome
title_full A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome
title_fullStr A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome
title_full_unstemmed A human isogenic iPSC-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in Down syndrome
title_sort human isogenic ipsc-derived cell line panel identifies major regulators of aberrant astrocyte proliferation in down syndrome
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e91008f5d0604ea7bd9c6ba4cad7e588
work_keys_str_mv AT keijikawatani ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT toshihikonambara ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT nobutoshinawa ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT hidetakayoshimatsu ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT harunakusakabe ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT katsuyahirata ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT akiratanave ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT kentasumiyama ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT kimihikobanno ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT hidetoshitaniguchi ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT hitomiarahori ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT keiichiozono ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT yasujikitabatake ahumanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT keijikawatani humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT toshihikonambara humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT nobutoshinawa humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT hidetakayoshimatsu humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT harunakusakabe humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT katsuyahirata humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT akiratanave humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT kentasumiyama humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT kimihikobanno humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT hidetoshitaniguchi humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT hitomiarahori humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT keiichiozono humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
AT yasujikitabatake humanisogenicipscderivedcelllinepanelidentifiesmajorregulatorsofaberrantastrocyteproliferationindownsyndrome
_version_ 1718379798272671744

Ejemplares similares