The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan

Aim. To perform the analysis of the association of transcription factor 7-like 2 (TCF7L2) gene rs7903146 polymorphism with type 2 diabetes mellitus (T2DM) among Tatars of Bashkortostan. Materials and methods. In this study, 169 patients with T2DM and 286 controls without clinical symptoms and labora...

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Autores principales:	Diana S. Avzaletdinova, Leisan F. Sharipova, Olga V. Kochetova, Tatyana Vyacheslavovna Morugova, Vera V. Erdman, Regina S. Somova, Olga E. Mustafina
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2016
Materias:	type 2 diabetes mellitus tcf7l2 molecular genetics Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/e9104020fa524b25b4954c3a76e07d82
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spelling	oai:doaj.org-article:e9104020fa524b25b4954c3a76e07d822021-11-14T09:00:20ZThe association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan2072-03512072-037810.14341/DM2004138-45https://doaj.org/article/e9104020fa524b25b4954c3a76e07d822016-05-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7111https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To perform the analysis of the association of transcription factor 7-like 2 (TCF7L2) gene rs7903146 polymorphism with type 2 diabetes mellitus (T2DM) among Tatars of Bashkortostan. Materials and methods. In this study, 169 patients with T2DM and 286 controls without clinical symptoms and laboratory signs of diabetes and without diabetes relatives were examined. Amplification of the DNA fragments was performed using real-time polymerase chain reaction (PCR) and TaqMan technique. Results. Genotype CT and allele T ratios were higher in the T2DM group than in controls (46. 7% vs. 36. 4%, p = 0. 030; 41. 7% vs. 30. 8%, p = 0. 001 respectively). There was a positive association between allele T and T2DM (OR = 1. 61), and allele C had a protective effect (OR = 0. 62, p = 0,001). Carriers of the ТТ genotype had later onset of T2DM (mean = 59. 5 years old) compared with carriers of the CT and CC genotypes (56. 1 years old, p = 0. 044). Basal C-peptide concentration, lipid levels and body mass index were not associated with TCF7L2 rs7903146 polymorphism. Conclusion. TCF7L2 rs7903146 polymorphism is associated with T2DM among Tatars of Bashkortostan.Diana S. AvzaletdinovaLeisan F. SharipovaOlga V. KochetovaTatyana Vyacheslavovna MorugovaVera V. ErdmanRegina S. SomovaOlga E. MustafinaEndocrinology Research Centrearticletype 2 diabetes mellitustcf7l2molecular geneticsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 19, Iss 2, Pp 119-124 (2016)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus tcf7l2 molecular genetics Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus tcf7l2 molecular genetics Nutritional diseases. Deficiency diseases RC620-627 Diana S. Avzaletdinova Leisan F. Sharipova Olga V. Kochetova Tatyana Vyacheslavovna Morugova Vera V. Erdman Regina S. Somova Olga E. Mustafina The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan
description	Aim. To perform the analysis of the association of transcription factor 7-like 2 (TCF7L2) gene rs7903146 polymorphism with type 2 diabetes mellitus (T2DM) among Tatars of Bashkortostan. Materials and methods. In this study, 169 patients with T2DM and 286 controls without clinical symptoms and laboratory signs of diabetes and without diabetes relatives were examined. Amplification of the DNA fragments was performed using real-time polymerase chain reaction (PCR) and TaqMan technique. Results. Genotype CT and allele T ratios were higher in the T2DM group than in controls (46. 7% vs. 36. 4%, p = 0. 030; 41. 7% vs. 30. 8%, p = 0. 001 respectively). There was a positive association between allele T and T2DM (OR = 1. 61), and allele C had a protective effect (OR = 0. 62, p = 0,001). Carriers of the ТТ genotype had later onset of T2DM (mean = 59. 5 years old) compared with carriers of the CT and CC genotypes (56. 1 years old, p = 0. 044). Basal C-peptide concentration, lipid levels and body mass index were not associated with TCF7L2 rs7903146 polymorphism. Conclusion. TCF7L2 rs7903146 polymorphism is associated with T2DM among Tatars of Bashkortostan.
format	article
author	Diana S. Avzaletdinova Leisan F. Sharipova Olga V. Kochetova Tatyana Vyacheslavovna Morugova Vera V. Erdman Regina S. Somova Olga E. Mustafina
author_facet	Diana S. Avzaletdinova Leisan F. Sharipova Olga V. Kochetova Tatyana Vyacheslavovna Morugova Vera V. Erdman Regina S. Somova Olga E. Mustafina
author_sort	Diana S. Avzaletdinova
title	The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan
title_short	The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan
title_full	The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan
title_fullStr	The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan
title_full_unstemmed	The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan
title_sort	association of tcf7l2 rs7903146 polymorphism with type 2 diabetes mellitus among tatars of bashkortostan
publisher	Endocrinology Research Centre
publishDate	2016
url	https://doaj.org/article/e9104020fa524b25b4954c3a76e07d82
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The association of TCF7L2 rs7903146 polymorphism with type 2 diabetes mellitus among Tatars of Bashkortostan

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