Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model

Context: Adlay seed [Job’s tears, Coix lachryma-jobi L. var. ma-yuen Stapf (Poaceae)] is a Traditional Chinese Medicine, which has been investigated to treat inflammatory diseases and rheumatism. Objective: This study evaluates the ameliorative effects of adlay seed extract (ASE) in a complete Freun...

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Autores principales:	Chunfang Zhang, Wenfeng Zhang, Rongyu Shi, Bangyi Tang, Shicheng Xie
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2019
Materias:	joint destruction paw oedema phenolic compounds antioxidant Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e910d9b698344111abd74808ce8bfff0
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spelling	oai:doaj.org-article:e910d9b698344111abd74808ce8bfff02021-11-17T14:21:56ZCoix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model1388-02091744-511610.1080/13880209.2019.1687526https://doaj.org/article/e910d9b698344111abd74808ce8bfff02019-01-01T00:00:00Zhttp://dx.doi.org/10.1080/13880209.2019.1687526https://doaj.org/toc/1388-0209https://doaj.org/toc/1744-5116Context: Adlay seed [Job’s tears, Coix lachryma-jobi L. var. ma-yuen Stapf (Poaceae)] is a Traditional Chinese Medicine, which has been investigated to treat inflammatory diseases and rheumatism. Objective: This study evaluates the ameliorative effects of adlay seed extract (ASE) in a complete Freund’s adjuvant (CFA)-induced rheumatoid arthritis (RA) rats. Materials and methods: The RA Sprague–Dawley rat model was induced and randomly divided into six groups with or without ASE treatment (50, 100 or 200 mg/kg). After 28 d administration, the symptoms, biochemical parameters and molecular mechanisms were investigated. Results: The values of paw oedema, PGE2 and MMP-3 decreased from 1.46 ± 0.04 to 0.66 ± 0.07 cm3, from 126.2 ± 11.48 to 79.71 ± 6.8 pg/mL and from 142.7 ± 8.36 to 86.51 ± 5.95 ng/mL, respectively; the values of body weight increased from 177.25 ± 5.94 to 205 ± 6.52 g in HASE group. In addition, treatment of ASE reduced the levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6, MCP-1), and increased the activities of antioxidant enzyme (GSH-Px, SOD, and CAT). Furthermore, ASE could suppress the mRNA expression of COX-2 and CHI3L1 and improve the mRNA expression of CAT and GPx-1 in ankle tissues of RA rats. Discussion and conclusions: For the first time, our results indicated ASE exerts anti-RA effects via inhibiting pro-inflammatory factors and alleviating oxidative stress. Our finding sheds light on the research and development of anti-RA functional foods from adlay seed.Chunfang ZhangWenfeng ZhangRongyu ShiBangyi TangShicheng XieTaylor & Francis Grouparticlejoint destructionpaw oedemaphenolic compoundsantioxidantTherapeutics. PharmacologyRM1-950ENPharmaceutical Biology, Vol 57, Iss 1, Pp 792-798 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	joint destruction paw oedema phenolic compounds antioxidant Therapeutics. Pharmacology RM1-950
spellingShingle	joint destruction paw oedema phenolic compounds antioxidant Therapeutics. Pharmacology RM1-950 Chunfang Zhang Wenfeng Zhang Rongyu Shi Bangyi Tang Shicheng Xie Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model
description	Context: Adlay seed [Job’s tears, Coix lachryma-jobi L. var. ma-yuen Stapf (Poaceae)] is a Traditional Chinese Medicine, which has been investigated to treat inflammatory diseases and rheumatism. Objective: This study evaluates the ameliorative effects of adlay seed extract (ASE) in a complete Freund’s adjuvant (CFA)-induced rheumatoid arthritis (RA) rats. Materials and methods: The RA Sprague–Dawley rat model was induced and randomly divided into six groups with or without ASE treatment (50, 100 or 200 mg/kg). After 28 d administration, the symptoms, biochemical parameters and molecular mechanisms were investigated. Results: The values of paw oedema, PGE2 and MMP-3 decreased from 1.46 ± 0.04 to 0.66 ± 0.07 cm3, from 126.2 ± 11.48 to 79.71 ± 6.8 pg/mL and from 142.7 ± 8.36 to 86.51 ± 5.95 ng/mL, respectively; the values of body weight increased from 177.25 ± 5.94 to 205 ± 6.52 g in HASE group. In addition, treatment of ASE reduced the levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6, MCP-1), and increased the activities of antioxidant enzyme (GSH-Px, SOD, and CAT). Furthermore, ASE could suppress the mRNA expression of COX-2 and CHI3L1 and improve the mRNA expression of CAT and GPx-1 in ankle tissues of RA rats. Discussion and conclusions: For the first time, our results indicated ASE exerts anti-RA effects via inhibiting pro-inflammatory factors and alleviating oxidative stress. Our finding sheds light on the research and development of anti-RA functional foods from adlay seed.
format	article
author	Chunfang Zhang Wenfeng Zhang Rongyu Shi Bangyi Tang Shicheng Xie
author_facet	Chunfang Zhang Wenfeng Zhang Rongyu Shi Bangyi Tang Shicheng Xie
author_sort	Chunfang Zhang
title	Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model
title_short	Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model
title_full	Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model
title_fullStr	Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model
title_full_unstemmed	Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model
title_sort	coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete freund’s adjuvant-induced rheumatoid arthritis model
publisher	Taylor & Francis Group
publishDate	2019
url	https://doaj.org/article/e910d9b698344111abd74808ce8bfff0
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Coix lachryma-jobi extract ameliorates inflammation and oxidative stress in a complete Freund’s adjuvant-induced rheumatoid arthritis model

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