Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells.

Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells.

Clofarabine, an FDA approved purine analog, is used in the treatment of relapsed or refractory acute lymphoblastic leukemia. Clofarabine acts by inhibiting DNA synthesis. We demonstrated that clofarabine may have a novel function though inhibiting CD99, a transmembrane protein highly expressed on Ew...

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Autores principales: Handan Sevim, Haydar Çelik, Levent Düşünceli, Ceyda S Ceyhan, Anna Molotkova, Kay Nakazawa, Garrett T Graham, Jeffrey R Petro, Jeffrey A Toretsky, Aykut Üren
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e9183073007d4d23ac98366b8bb127d1
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