Upregulated glycolysis correlates with tumor progression and immune evasion in head and neck squamous cell carcinoma

Abstract Altered metabolism is an emerging hallmark of cancer. Cancer cells preferentially utilize glycolysis for energy production, termed “aerobic glycolysis.” In this study, we performed a comprehensive analysis of the glycolytic activity in head and neck squamous cell carcinoma (HNSCC) using dat...

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Autores principales:	Hideyuki Takahashi, Reika Kawabata-Iwakawa, Shota Ida, Ikko Mito, Hiroe Tada, Kazuaki Chikamatsu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e91c6c8c9ce0479fb7ba42f7cdf46e24
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spelling	oai:doaj.org-article:e91c6c8c9ce0479fb7ba42f7cdf46e242021-12-02T17:41:18ZUpregulated glycolysis correlates with tumor progression and immune evasion in head and neck squamous cell carcinoma10.1038/s41598-021-97292-62045-2322https://doaj.org/article/e91c6c8c9ce0479fb7ba42f7cdf46e242021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97292-6https://doaj.org/toc/2045-2322Abstract Altered metabolism is an emerging hallmark of cancer. Cancer cells preferentially utilize glycolysis for energy production, termed “aerobic glycolysis.” In this study, we performed a comprehensive analysis of the glycolytic activity in head and neck squamous cell carcinoma (HNSCC) using data obtained from The Cancer Genome Atlas database. We first divided 520 patients with HNSCC into four groups based on the mRNA expression of 16 glycolysis-related genes. The upregulated glycolytic activity positively correlated with human papillomavirus-negative tumor type, advanced T factor, and unfavorable prognosis. The gene set enrichment analysis revealed upregulation of several hallmark pathways, including interferon-alpha response, myc targets, unfolded protein response, transforming growth factor-β signaling, cholesterol homeostasis, and interleukin 6-Janus kinase-signal transducer and activator of transcription 3 signaling, in the glycolysis-upregulated groups. Immune cell enrichment analysis revealed decreased infiltration of T cells, dendritic cells, and B cells in the glycolysis-upregulated groups, suggesting impaired tumor antigen presentation, T cell activation, and antibody production in the TME. Moreover, the expression profile of immune-related genes indicated increased immune evasion in the glycolysis-upregulated tumors. Collectively, these findings suggest that transcriptome analysis of glycolytic activity of tumors has the potential as a biomarker for tumor progression and immunological status in patients with HNSCC.Hideyuki TakahashiReika Kawabata-IwakawaShota IdaIkko MitoHiroe TadaKazuaki ChikamatsuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hideyuki Takahashi Reika Kawabata-Iwakawa Shota Ida Ikko Mito Hiroe Tada Kazuaki Chikamatsu Upregulated glycolysis correlates with tumor progression and immune evasion in head and neck squamous cell carcinoma
description	Abstract Altered metabolism is an emerging hallmark of cancer. Cancer cells preferentially utilize glycolysis for energy production, termed “aerobic glycolysis.” In this study, we performed a comprehensive analysis of the glycolytic activity in head and neck squamous cell carcinoma (HNSCC) using data obtained from The Cancer Genome Atlas database. We first divided 520 patients with HNSCC into four groups based on the mRNA expression of 16 glycolysis-related genes. The upregulated glycolytic activity positively correlated with human papillomavirus-negative tumor type, advanced T factor, and unfavorable prognosis. The gene set enrichment analysis revealed upregulation of several hallmark pathways, including interferon-alpha response, myc targets, unfolded protein response, transforming growth factor-β signaling, cholesterol homeostasis, and interleukin 6-Janus kinase-signal transducer and activator of transcription 3 signaling, in the glycolysis-upregulated groups. Immune cell enrichment analysis revealed decreased infiltration of T cells, dendritic cells, and B cells in the glycolysis-upregulated groups, suggesting impaired tumor antigen presentation, T cell activation, and antibody production in the TME. Moreover, the expression profile of immune-related genes indicated increased immune evasion in the glycolysis-upregulated tumors. Collectively, these findings suggest that transcriptome analysis of glycolytic activity of tumors has the potential as a biomarker for tumor progression and immunological status in patients with HNSCC.
format	article
author	Hideyuki Takahashi Reika Kawabata-Iwakawa Shota Ida Ikko Mito Hiroe Tada Kazuaki Chikamatsu
author_facet	Hideyuki Takahashi Reika Kawabata-Iwakawa Shota Ida Ikko Mito Hiroe Tada Kazuaki Chikamatsu
author_sort	Hideyuki Takahashi
title	Upregulated glycolysis correlates with tumor progression and immune evasion in head and neck squamous cell carcinoma
title_short	Upregulated glycolysis correlates with tumor progression and immune evasion in head and neck squamous cell carcinoma
title_full	Upregulated glycolysis correlates with tumor progression and immune evasion in head and neck squamous cell carcinoma
title_fullStr	Upregulated glycolysis correlates with tumor progression and immune evasion in head and neck squamous cell carcinoma
title_full_unstemmed	Upregulated glycolysis correlates with tumor progression and immune evasion in head and neck squamous cell carcinoma
title_sort	upregulated glycolysis correlates with tumor progression and immune evasion in head and neck squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e91c6c8c9ce0479fb7ba42f7cdf46e24
work_keys_str_mv	AT hideyukitakahashi upregulatedglycolysiscorrelateswithtumorprogressionandimmuneevasioninheadandnecksquamouscellcarcinoma AT reikakawabataiwakawa upregulatedglycolysiscorrelateswithtumorprogressionandimmuneevasioninheadandnecksquamouscellcarcinoma AT shotaida upregulatedglycolysiscorrelateswithtumorprogressionandimmuneevasioninheadandnecksquamouscellcarcinoma AT ikkomito upregulatedglycolysiscorrelateswithtumorprogressionandimmuneevasioninheadandnecksquamouscellcarcinoma AT hiroetada upregulatedglycolysiscorrelateswithtumorprogressionandimmuneevasioninheadandnecksquamouscellcarcinoma AT kazuakichikamatsu upregulatedglycolysiscorrelateswithtumorprogressionandimmuneevasioninheadandnecksquamouscellcarcinoma
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Upregulated glycolysis correlates with tumor progression and immune evasion in head and neck squamous cell carcinoma

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