Isochoric supercooled preservation and revival of human cardiac microtissues

Powell-Palm et al. demonstrate sub-zero centigrade preservation and revival of autonomously beating, 3D human induced pluripotent stem cell (hiPSC)-derived cardiac microtissues via isochoric supercooling, without the use of chemical cryoprotectants. Their study suggests that functional 3D engineered...

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Autores principales:	Matthew J. Powell-Palm, Verena Charwat, Berenice Charrez, Brian Siemons, Kevin E. Healy, Boris Rubinsky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e91e22959744442889b1812d5fc408b0
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spelling	oai:doaj.org-article:e91e22959744442889b1812d5fc408b02021-12-02T18:48:42ZIsochoric supercooled preservation and revival of human cardiac microtissues10.1038/s42003-021-02650-92399-3642https://doaj.org/article/e91e22959744442889b1812d5fc408b02021-09-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02650-9https://doaj.org/toc/2399-3642Powell-Palm et al. demonstrate sub-zero centigrade preservation and revival of autonomously beating, 3D human induced pluripotent stem cell (hiPSC)-derived cardiac microtissues via isochoric supercooling, without the use of chemical cryoprotectants. Their study suggests that functional 3D engineered tissues may provide a high-content, low-risk testbed to study complex tissue biopreservation in a genetically human context, and that isochoric supercooling may provide a robust method for preserving and reviving engineered tissues themselves.Matthew J. Powell-PalmVerena CharwatBerenice CharrezBrian SiemonsKevin E. HealyBoris RubinskyNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Matthew J. Powell-Palm Verena Charwat Berenice Charrez Brian Siemons Kevin E. Healy Boris Rubinsky Isochoric supercooled preservation and revival of human cardiac microtissues
description	Powell-Palm et al. demonstrate sub-zero centigrade preservation and revival of autonomously beating, 3D human induced pluripotent stem cell (hiPSC)-derived cardiac microtissues via isochoric supercooling, without the use of chemical cryoprotectants. Their study suggests that functional 3D engineered tissues may provide a high-content, low-risk testbed to study complex tissue biopreservation in a genetically human context, and that isochoric supercooling may provide a robust method for preserving and reviving engineered tissues themselves.
format	article
author	Matthew J. Powell-Palm Verena Charwat Berenice Charrez Brian Siemons Kevin E. Healy Boris Rubinsky
author_facet	Matthew J. Powell-Palm Verena Charwat Berenice Charrez Brian Siemons Kevin E. Healy Boris Rubinsky
author_sort	Matthew J. Powell-Palm
title	Isochoric supercooled preservation and revival of human cardiac microtissues
title_short	Isochoric supercooled preservation and revival of human cardiac microtissues
title_full	Isochoric supercooled preservation and revival of human cardiac microtissues
title_fullStr	Isochoric supercooled preservation and revival of human cardiac microtissues
title_full_unstemmed	Isochoric supercooled preservation and revival of human cardiac microtissues
title_sort	isochoric supercooled preservation and revival of human cardiac microtissues
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e91e22959744442889b1812d5fc408b0
work_keys_str_mv	AT matthewjpowellpalm isochoricsupercooledpreservationandrevivalofhumancardiacmicrotissues AT verenacharwat isochoricsupercooledpreservationandrevivalofhumancardiacmicrotissues AT berenicecharrez isochoricsupercooledpreservationandrevivalofhumancardiacmicrotissues AT briansiemons isochoricsupercooledpreservationandrevivalofhumancardiacmicrotissues AT kevinehealy isochoricsupercooledpreservationandrevivalofhumancardiacmicrotissues AT borisrubinsky isochoricsupercooledpreservationandrevivalofhumancardiacmicrotissues
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Isochoric supercooled preservation and revival of human cardiac microtissues

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