The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon

Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor that may be complicated by Kasabach-Merritt phenomenon (KMP), a profound thrombocytopenia resulting from platelet trapping within a vascular tumor, either KHE or tufted angioma (TA). Typical features also include low fibri...

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Autores principales:	Grecia V. Vivas-Colmenares, Gema L. Ramirez-Villar, Jose A. Matute de Cardenas, Jose Bernabeu-Wittel, Israel Fernandez-Pineda
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2015
Materias:	kaposiform hemangioendothelioma Kasabach-Merritt phenomenon vincristine ticlopidine aspirin Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/e91ec3558c7a47f5bd89f34fd50fc022
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spelling	oai:doaj.org-article:e91ec3558c7a47f5bd89f34fd50fc0222021-11-17T08:31:48ZThe importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon10.5826/dpc.0501a182160-9381https://doaj.org/article/e91ec3558c7a47f5bd89f34fd50fc0222015-01-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/865https://doaj.org/toc/2160-9381 Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor that may be complicated by Kasabach-Merritt phenomenon (KMP), a profound thrombocytopenia resulting from platelet trapping within a vascular tumor, either KHE or tufted angioma (TA). Typical features also include low fibrinogen and elevated D-dimers. It is well known that KMP is not caused by infantile hemangiomas. Management of vascular tumors complicated by KMP is challenging, and it is common for referral centers to receive patients in critical medical condition after multimodality treatment failure of vascular anomalies. Our aim is to communicate the importance of early diagnosis and treatment of KHE associated with KMP. A full-term male newborn with KHE complicated by KMP is reported. Treatment with vincristine, aspirin and ticlopidine normalized the coagulation parameters within one week, requiring a total of six doses of vincristine, seven months of ticlopidine and 17 months of aspirin. Early diagnosis and treatment of KHE complicated by KMP may allow the administration of fewer doses of vincristine and avoid the use of corticosteroids. Grecia V. Vivas-ColmenaresGema L. Ramirez-VillarJose A. Matute de CardenasJose Bernabeu-WittelIsrael Fernandez-PinedaMattioli1885articlekaposiform hemangioendotheliomaKasabach-Merritt phenomenonvincristineticlopidineaspirinDermatologyRL1-803ENDermatology Practical & Conceptual (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	kaposiform hemangioendothelioma Kasabach-Merritt phenomenon vincristine ticlopidine aspirin Dermatology RL1-803
spellingShingle	kaposiform hemangioendothelioma Kasabach-Merritt phenomenon vincristine ticlopidine aspirin Dermatology RL1-803 Grecia V. Vivas-Colmenares Gema L. Ramirez-Villar Jose A. Matute de Cardenas Jose Bernabeu-Wittel Israel Fernandez-Pineda The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon
description	Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor that may be complicated by Kasabach-Merritt phenomenon (KMP), a profound thrombocytopenia resulting from platelet trapping within a vascular tumor, either KHE or tufted angioma (TA). Typical features also include low fibrinogen and elevated D-dimers. It is well known that KMP is not caused by infantile hemangiomas. Management of vascular tumors complicated by KMP is challenging, and it is common for referral centers to receive patients in critical medical condition after multimodality treatment failure of vascular anomalies. Our aim is to communicate the importance of early diagnosis and treatment of KHE associated with KMP. A full-term male newborn with KHE complicated by KMP is reported. Treatment with vincristine, aspirin and ticlopidine normalized the coagulation parameters within one week, requiring a total of six doses of vincristine, seven months of ticlopidine and 17 months of aspirin. Early diagnosis and treatment of KHE complicated by KMP may allow the administration of fewer doses of vincristine and avoid the use of corticosteroids.
format	article
author	Grecia V. Vivas-Colmenares Gema L. Ramirez-Villar Jose A. Matute de Cardenas Jose Bernabeu-Wittel Israel Fernandez-Pineda
author_facet	Grecia V. Vivas-Colmenares Gema L. Ramirez-Villar Jose A. Matute de Cardenas Jose Bernabeu-Wittel Israel Fernandez-Pineda
author_sort	Grecia V. Vivas-Colmenares
title	The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon
title_short	The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon
title_full	The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon
title_fullStr	The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon
title_full_unstemmed	The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon
title_sort	importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by kasabach-merritt phenomenon
publisher	Mattioli1885
publishDate	2015
url	https://doaj.org/article/e91ec3558c7a47f5bd89f34fd50fc022
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The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon

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