Role of IFN and Complements System: Innate Immunity in SARS-CoV-2

Tewodros Shibabaw,1 Meseret Derbew Molla,1 Banchamlak Teferi,2 Birhanu Ayelign3 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Scien...

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Autores principales:	Shibabaw T, Molla MD, Teferi B, Ayelign B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	sars-cov-2 innate immune cytokines complement ifns virulent Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/e91f90d19929487e8b4d8417e9c22595
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spelling	oai:doaj.org-article:e91f90d19929487e8b4d8417e9c225952021-12-02T10:30:11ZRole of IFN and Complements System: Innate Immunity in SARS-CoV-21178-7031https://doaj.org/article/e91f90d19929487e8b4d8417e9c225952020-09-01T00:00:00Zhttps://www.dovepress.com/role-of-ifn-and-complements-system-innate-immunity-in-sars-cov-2-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Tewodros Shibabaw,1 Meseret Derbew Molla,1 Banchamlak Teferi,2 Birhanu Ayelign3 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Tewodros Shibabaw Email shitewodros@gmail.comAbstract: The critical role of the innate immune system has been confirmed in driving local and systemic inflammation and the cytokine release storm in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This dysregulated immune response is focused on interferon (IFN) and complement activation, which are crucial for the development of metabolic inflammation, local lung tissue damage, and systemic multi-organ failure. IFNs control viral infections by inducing expression of IFN-stimulated genes (ISGs) that restrict distinct steps of viral replication. Therefore, in this review article, we propose the mechanism of SARS-CoV-2-associated acute respiratory disease syndrome, and assess treatment options by considering IFNs and by targeting IFN-antagonist SARS-CoV-2 virulent gene products. Furthermore, we elaborate on the mechanism of the amplified complement-mediated inflammatory cytokine storm, and propose an antiviral and immunotherapeutic strategy against coronavirus disease 2019 (COVID-19).Keywords: SARS-CoV-2, innate immune system, cytokines, complement, IFNs, virulentShibabaw TMolla MDTeferi BAyelign BDove Medical Pressarticlesars-cov-2innate immunecytokinescomplementifnsvirulentPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 13, Pp 507-518 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	sars-cov-2 innate immune cytokines complement ifns virulent Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	sars-cov-2 innate immune cytokines complement ifns virulent Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Shibabaw T Molla MD Teferi B Ayelign B Role of IFN and Complements System: Innate Immunity in SARS-CoV-2
description	Tewodros Shibabaw,1 Meseret Derbew Molla,1 Banchamlak Teferi,2 Birhanu Ayelign3 1Department of Biochemistry, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3Department of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Tewodros Shibabaw Email shitewodros@gmail.comAbstract: The critical role of the innate immune system has been confirmed in driving local and systemic inflammation and the cytokine release storm in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This dysregulated immune response is focused on interferon (IFN) and complement activation, which are crucial for the development of metabolic inflammation, local lung tissue damage, and systemic multi-organ failure. IFNs control viral infections by inducing expression of IFN-stimulated genes (ISGs) that restrict distinct steps of viral replication. Therefore, in this review article, we propose the mechanism of SARS-CoV-2-associated acute respiratory disease syndrome, and assess treatment options by considering IFNs and by targeting IFN-antagonist SARS-CoV-2 virulent gene products. Furthermore, we elaborate on the mechanism of the amplified complement-mediated inflammatory cytokine storm, and propose an antiviral and immunotherapeutic strategy against coronavirus disease 2019 (COVID-19).Keywords: SARS-CoV-2, innate immune system, cytokines, complement, IFNs, virulent
format	article
author	Shibabaw T Molla MD Teferi B Ayelign B
author_facet	Shibabaw T Molla MD Teferi B Ayelign B
author_sort	Shibabaw T
title	Role of IFN and Complements System: Innate Immunity in SARS-CoV-2
title_short	Role of IFN and Complements System: Innate Immunity in SARS-CoV-2
title_full	Role of IFN and Complements System: Innate Immunity in SARS-CoV-2
title_fullStr	Role of IFN and Complements System: Innate Immunity in SARS-CoV-2
title_full_unstemmed	Role of IFN and Complements System: Innate Immunity in SARS-CoV-2
title_sort	role of ifn and complements system: innate immunity in sars-cov-2
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e91f90d19929487e8b4d8417e9c22595
work_keys_str_mv	AT shibabawt roleofifnandcomplementssysteminnateimmunityinsarscov2 AT mollamd roleofifnandcomplementssysteminnateimmunityinsarscov2 AT teferib roleofifnandcomplementssysteminnateimmunityinsarscov2 AT ayelignb roleofifnandcomplementssysteminnateimmunityinsarscov2
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Role of IFN and Complements System: Innate Immunity in SARS-CoV-2

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