Differential Diagnosis Of Multiple-System Atrophy With Parkinson’s Disease By External Anal- And Urethral-Sphincter Electromyography

Feng Qiu,1,* Kunyu Wang,1,* Tingting Li,2 Dandan Song,3 Zhiwei Wang,1 Hailing Zhang,4 Jianguo Liu,1 Ming Ren,5 Xiaokun Qi1 1Department of Neurology, Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, People’s Republic of China; 2Department of Gastroenterology, Second Me...

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Autores principales:	Qiu F, Wang K, Li T, Song D, Wang Z, Zhang H, Liu J, Ren M, Qi X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	differential diagnosis msa pd eas-emg us-emg Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e92985a1ac714829a233afbe8dafa280
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spelling	oai:doaj.org-article:e92985a1ac714829a233afbe8dafa2802021-12-02T06:42:26ZDifferential Diagnosis Of Multiple-System Atrophy With Parkinson’s Disease By External Anal- And Urethral-Sphincter Electromyography1178-2021https://doaj.org/article/e92985a1ac714829a233afbe8dafa2802019-11-01T00:00:00Zhttps://www.dovepress.com/differential-diagnosis-of-multiple-system-atrophy-with-parkinsona-dise-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Feng Qiu,1,* Kunyu Wang,1,* Tingting Li,2 Dandan Song,3 Zhiwei Wang,1 Hailing Zhang,4 Jianguo Liu,1 Ming Ren,5 Xiaokun Qi1 1Department of Neurology, Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, People’s Republic of China; 2Department of Gastroenterology, Second Medical Center of Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China; 3Department of Medicine, Beijing Northern Hospital of China North Industries Group Corporation, Beijing 100089, People’s Republic of China; 4Department of Neurology, Changhai Hospital, Shanghai 200433, People’s Republic of China; 5Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing 100191, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaokun QiDepartment of Neurology, Sixth Medical Center of PLA General Hospital, 6 Fucheng Road, Haidian District, Beijing 100048, People’s Republic of ChinaTel +86 139 1079 7081Email bjqxk@sina.com Ming RenBeijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, 37 Xueyuan Road, Haidian District, Beijing 100191, People’s Republic of ChinaTel +86 139 1079 7081Email mren201017@hotmail.comBackground: The differential diagnosis of Parkinson’s disease (PD) with multiple-system atrophy (MSA) is difficult because of their similarity in symptoms and signs. The objective of this study was to investigate the value of external anal-sphincter electromyography (EAS-EMG) and urethral-sphincter electromyography (US-EMG) in differentiating MSA from PD.Methods: A total of 201 patients, — 101 MSA and 100 PD — were recruited in this study. Average duration and amplitude of motor unit potentials (MUPs), percentage of polyphasic MUPs, amplitude during strong contractions, and recruitment patterns during maximal voluntary contractions were recorded and analyzed to assess diagnostic efficiency of EAS-EMG and US-EMG for MSA.Results: Significant differences in average MUP duration and recruitment patterns during maximal voluntary contractions were found between patients with MSA and patients with PD using both EAS-EMG (P<0.001, P<0.001) and US-EMG (P<0.001, P<0.001). The percentage of polyphasic MUPs and amplitude during strong contractions showed significant differences in MSA and PD using only EAS-EMG (P<0.001, P=0.005). Cutoff points for average MUP duration in EAS-EMG and US-EMG for differential diagnosis of MSA with PD were 10.9 and 11.1 milliseconds, respectively. With average MUP duration of EAS-EMG and US-EMG being applied jointly, sensitivity and specificity in distinguishing MSA from PD were 83.2% and 71.8%, respectively.Conclusion: EAS-EMG and US-EMG were sensitive and specific methods for the diagnosis and differential diagnosis of MSA, and the combination of both would improve the diagnostic rate of MSA compared to only one method being used.Keywords: differential diagnosis, MSA, PD, EAS-EMG, US-EMGQiu FWang KLi TSong DWang ZZhang HLiu JRen MQi XDove Medical Pressarticledifferential diagnosismsapdeas-emgus-emgNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 3061-3067 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	differential diagnosis msa pd eas-emg us-emg Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	differential diagnosis msa pd eas-emg us-emg Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Qiu F Wang K Li T Song D Wang Z Zhang H Liu J Ren M Qi X Differential Diagnosis Of Multiple-System Atrophy With Parkinson’s Disease By External Anal- And Urethral-Sphincter Electromyography
description	Feng Qiu,1,* Kunyu Wang,1,* Tingting Li,2 Dandan Song,3 Zhiwei Wang,1 Hailing Zhang,4 Jianguo Liu,1 Ming Ren,5 Xiaokun Qi1 1Department of Neurology, Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, People’s Republic of China; 2Department of Gastroenterology, Second Medical Center of Chinese PLA General Hospital, Beijing, 100853, People’s Republic of China; 3Department of Medicine, Beijing Northern Hospital of China North Industries Group Corporation, Beijing 100089, People’s Republic of China; 4Department of Neurology, Changhai Hospital, Shanghai 200433, People’s Republic of China; 5Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing 100191, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaokun QiDepartment of Neurology, Sixth Medical Center of PLA General Hospital, 6 Fucheng Road, Haidian District, Beijing 100048, People’s Republic of ChinaTel +86 139 1079 7081Email bjqxk@sina.com Ming RenBeijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, 37 Xueyuan Road, Haidian District, Beijing 100191, People’s Republic of ChinaTel +86 139 1079 7081Email mren201017@hotmail.comBackground: The differential diagnosis of Parkinson’s disease (PD) with multiple-system atrophy (MSA) is difficult because of their similarity in symptoms and signs. The objective of this study was to investigate the value of external anal-sphincter electromyography (EAS-EMG) and urethral-sphincter electromyography (US-EMG) in differentiating MSA from PD.Methods: A total of 201 patients, — 101 MSA and 100 PD — were recruited in this study. Average duration and amplitude of motor unit potentials (MUPs), percentage of polyphasic MUPs, amplitude during strong contractions, and recruitment patterns during maximal voluntary contractions were recorded and analyzed to assess diagnostic efficiency of EAS-EMG and US-EMG for MSA.Results: Significant differences in average MUP duration and recruitment patterns during maximal voluntary contractions were found between patients with MSA and patients with PD using both EAS-EMG (P<0.001, P<0.001) and US-EMG (P<0.001, P<0.001). The percentage of polyphasic MUPs and amplitude during strong contractions showed significant differences in MSA and PD using only EAS-EMG (P<0.001, P=0.005). Cutoff points for average MUP duration in EAS-EMG and US-EMG for differential diagnosis of MSA with PD were 10.9 and 11.1 milliseconds, respectively. With average MUP duration of EAS-EMG and US-EMG being applied jointly, sensitivity and specificity in distinguishing MSA from PD were 83.2% and 71.8%, respectively.Conclusion: EAS-EMG and US-EMG were sensitive and specific methods for the diagnosis and differential diagnosis of MSA, and the combination of both would improve the diagnostic rate of MSA compared to only one method being used.Keywords: differential diagnosis, MSA, PD, EAS-EMG, US-EMG
format	article
author	Qiu F Wang K Li T Song D Wang Z Zhang H Liu J Ren M Qi X
author_facet	Qiu F Wang K Li T Song D Wang Z Zhang H Liu J Ren M Qi X
author_sort	Qiu F
title	Differential Diagnosis Of Multiple-System Atrophy With Parkinson’s Disease By External Anal- And Urethral-Sphincter Electromyography
title_short	Differential Diagnosis Of Multiple-System Atrophy With Parkinson’s Disease By External Anal- And Urethral-Sphincter Electromyography
title_full	Differential Diagnosis Of Multiple-System Atrophy With Parkinson’s Disease By External Anal- And Urethral-Sphincter Electromyography
title_fullStr	Differential Diagnosis Of Multiple-System Atrophy With Parkinson’s Disease By External Anal- And Urethral-Sphincter Electromyography
title_full_unstemmed	Differential Diagnosis Of Multiple-System Atrophy With Parkinson’s Disease By External Anal- And Urethral-Sphincter Electromyography
title_sort	differential diagnosis of multiple-system atrophy with parkinson’s disease by external anal- and urethral-sphincter electromyography
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/e92985a1ac714829a233afbe8dafa280
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Differential Diagnosis Of Multiple-System Atrophy With Parkinson’s Disease By External Anal- And Urethral-Sphincter Electromyography

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