Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors.
Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role of semaphorin 3F (SEMA3F) and its receptor ne...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2014
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/e929d10fb6bf40a49a91edc2a5b6e629 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:e929d10fb6bf40a49a91edc2a5b6e629 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:e929d10fb6bf40a49a91edc2a5b6e6292021-11-25T06:06:56ZSemaphorin 3F and neuropilin-2 control the migration of human T-cell precursors.1932-620310.1371/journal.pone.0103405https://doaj.org/article/e929d10fb6bf40a49a91edc2a5b6e6292014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25068647/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role of semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) in human T cell precursors. NRP2 and SEMA3F are expressed in the human thymus, in both lymphoid and non-lymphoid compartments. SEMA3F have a repulsive effect on thymocyte migration and inhibited CXCL12- and sphingosine-1-phosphate (S1P)-induced thymocyte migration by inhibiting cytoskeleton reorganization prior to stimuli. Moreover, NRP2 and SEMA3F are expressed in human T-cell acute lymphoblastic leukemia/lymphoma primary cells. In these tumor cells, SEMA3F also blocks their migration induced by CXCL12 and S1P. Our data show that SEMA3F and NRP2 are further regulators of human thymocyte migration in physiological and pathological conditions.Daniella Arêas Mendes-da-CruzAnne Colette BrignierVahid AsnafiFrederic BaleydierCarolina Valença MessiasYves LepelletierNawel BedjaouiAmedée RenandSalete SmaniottoDanielle CanioniPierre MilpiedKarl BalabanianPhilippe BoussoStéphane LeprêtreYves BertrandHervé DombretNorbert IfrahMireille DardenneElizabeth MacintyreWilson SavinoOlivier HerminePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e103405 (2014) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Daniella Arêas Mendes-da-Cruz Anne Colette Brignier Vahid Asnafi Frederic Baleydier Carolina Valença Messias Yves Lepelletier Nawel Bedjaoui Amedée Renand Salete Smaniotto Danielle Canioni Pierre Milpied Karl Balabanian Philippe Bousso Stéphane Leprêtre Yves Bertrand Hervé Dombret Norbert Ifrah Mireille Dardenne Elizabeth Macintyre Wilson Savino Olivier Hermine Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. |
| description |
Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role of semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) in human T cell precursors. NRP2 and SEMA3F are expressed in the human thymus, in both lymphoid and non-lymphoid compartments. SEMA3F have a repulsive effect on thymocyte migration and inhibited CXCL12- and sphingosine-1-phosphate (S1P)-induced thymocyte migration by inhibiting cytoskeleton reorganization prior to stimuli. Moreover, NRP2 and SEMA3F are expressed in human T-cell acute lymphoblastic leukemia/lymphoma primary cells. In these tumor cells, SEMA3F also blocks their migration induced by CXCL12 and S1P. Our data show that SEMA3F and NRP2 are further regulators of human thymocyte migration in physiological and pathological conditions. |
| format |
article |
| author |
Daniella Arêas Mendes-da-Cruz Anne Colette Brignier Vahid Asnafi Frederic Baleydier Carolina Valença Messias Yves Lepelletier Nawel Bedjaoui Amedée Renand Salete Smaniotto Danielle Canioni Pierre Milpied Karl Balabanian Philippe Bousso Stéphane Leprêtre Yves Bertrand Hervé Dombret Norbert Ifrah Mireille Dardenne Elizabeth Macintyre Wilson Savino Olivier Hermine |
| author_facet |
Daniella Arêas Mendes-da-Cruz Anne Colette Brignier Vahid Asnafi Frederic Baleydier Carolina Valença Messias Yves Lepelletier Nawel Bedjaoui Amedée Renand Salete Smaniotto Danielle Canioni Pierre Milpied Karl Balabanian Philippe Bousso Stéphane Leprêtre Yves Bertrand Hervé Dombret Norbert Ifrah Mireille Dardenne Elizabeth Macintyre Wilson Savino Olivier Hermine |
| author_sort |
Daniella Arêas Mendes-da-Cruz |
| title |
Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. |
| title_short |
Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. |
| title_full |
Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. |
| title_fullStr |
Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. |
| title_full_unstemmed |
Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. |
| title_sort |
semaphorin 3f and neuropilin-2 control the migration of human t-cell precursors. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/e929d10fb6bf40a49a91edc2a5b6e629 |
| work_keys_str_mv |
AT daniellaareasmendesdacruz semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT annecolettebrignier semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT vahidasnafi semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT fredericbaleydier semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT carolinavalencamessias semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT yveslepelletier semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT nawelbedjaoui semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT amedeerenand semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT saletesmaniotto semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT daniellecanioni semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT pierremilpied semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT karlbalabanian semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT philippebousso semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT stephanelepretre semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT yvesbertrand semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT hervedombret semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT norbertifrah semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT mireilledardenne semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT elizabethmacintyre semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT wilsonsavino semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors AT olivierhermine semaphorin3fandneuropilin2controlthemigrationofhumantcellprecursors |
| _version_ |
1718414196188643328 |