Oncolytic Virotherapy: From Bench to Bedside

Oncolytic viruses are naturally occurring or genetically engineered viruses that can replicate preferentially in tumor cells and inhibit tumor growth. These viruses have been considered an effective anticancer strategy in recent years. They mainly function by direct oncolysis, inducing an anticancer...

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Autores principales:	Ludi Yang, Xiang Gu, Jie Yu, Shengfang Ge, Xianqun Fan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	oncolytic virus tumor immunity mechanisms clinical applications Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e92a569999d948fc955277a132536cef
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spelling	oai:doaj.org-article:e92a569999d948fc955277a132536cef2021-12-01T07:46:37ZOncolytic Virotherapy: From Bench to Bedside2296-634X10.3389/fcell.2021.790150https://doaj.org/article/e92a569999d948fc955277a132536cef2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.790150/fullhttps://doaj.org/toc/2296-634XOncolytic viruses are naturally occurring or genetically engineered viruses that can replicate preferentially in tumor cells and inhibit tumor growth. These viruses have been considered an effective anticancer strategy in recent years. They mainly function by direct oncolysis, inducing an anticancer immune response and expressing exogenous effector genes. Their multifunctional characteristics indicate good application prospects as cancer therapeutics, especially in combination with other therapies, such as radiotherapy, chemotherapy and immunotherapy. Therefore, it is necessary to comprehensively understand the utility of oncolytic viruses in cancer therapeutics. Here, we review the characteristics, antitumor mechanisms, clinical applications, deficiencies and associated solutions, and future prospects of oncolytic viruses.Ludi YangLudi YangXiang GuXiang GuJie YuJie YuShengfang GeShengfang GeXianqun FanXianqun FanFrontiers Media S.A.articleoncolytic virustumorimmunitymechanismsclinical applicationsBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oncolytic virus tumor immunity mechanisms clinical applications Biology (General) QH301-705.5
spellingShingle	oncolytic virus tumor immunity mechanisms clinical applications Biology (General) QH301-705.5 Ludi Yang Ludi Yang Xiang Gu Xiang Gu Jie Yu Jie Yu Shengfang Ge Shengfang Ge Xianqun Fan Xianqun Fan Oncolytic Virotherapy: From Bench to Bedside
description	Oncolytic viruses are naturally occurring or genetically engineered viruses that can replicate preferentially in tumor cells and inhibit tumor growth. These viruses have been considered an effective anticancer strategy in recent years. They mainly function by direct oncolysis, inducing an anticancer immune response and expressing exogenous effector genes. Their multifunctional characteristics indicate good application prospects as cancer therapeutics, especially in combination with other therapies, such as radiotherapy, chemotherapy and immunotherapy. Therefore, it is necessary to comprehensively understand the utility of oncolytic viruses in cancer therapeutics. Here, we review the characteristics, antitumor mechanisms, clinical applications, deficiencies and associated solutions, and future prospects of oncolytic viruses.
format	article
author	Ludi Yang Ludi Yang Xiang Gu Xiang Gu Jie Yu Jie Yu Shengfang Ge Shengfang Ge Xianqun Fan Xianqun Fan
author_facet	Ludi Yang Ludi Yang Xiang Gu Xiang Gu Jie Yu Jie Yu Shengfang Ge Shengfang Ge Xianqun Fan Xianqun Fan
author_sort	Ludi Yang
title	Oncolytic Virotherapy: From Bench to Bedside
title_short	Oncolytic Virotherapy: From Bench to Bedside
title_full	Oncolytic Virotherapy: From Bench to Bedside
title_fullStr	Oncolytic Virotherapy: From Bench to Bedside
title_full_unstemmed	Oncolytic Virotherapy: From Bench to Bedside
title_sort	oncolytic virotherapy: from bench to bedside
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e92a569999d948fc955277a132536cef
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Oncolytic Virotherapy: From Bench to Bedside

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