Prevalence and Determinants of Long-Term Utilization of Antidepressant Drugs: A Retrospective Cohort Study

Carlotta Lunghi,1– 3 Ippazio Cosimo Antonazzo,2 Sofia Burato,2 Emanuel Raschi,2 Violetta Zoffoli,2 Emanuele Forcesi,2 Elisa Sangiorgi,4 Marco Menchetti,5 Pasquale Roberge,3,6 Elisabetta Poluzzi2 1Department of Health Sciences, Université Du Québec À Rimousk...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lunghi C, Antonazzo IC, Burato S, Raschi E, Zoffoli V, Forcesi E, Sangiorgi E, Menchetti M, Roberge P, Poluzzi E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	antidepressants depression anxiety/anxiety disorders primary care pharmacotherapy adherence epidemiology pharmacoepidemiology treatment. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/e92b0427f53b4d249e408253cc39f5d4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e92b0427f53b4d249e408253cc39f5d4
record_format	dspace
spelling	oai:doaj.org-article:e92b0427f53b4d249e408253cc39f5d42021-12-02T10:06:42ZPrevalence and Determinants of Long-Term Utilization of Antidepressant Drugs: A Retrospective Cohort Study1178-2021https://doaj.org/article/e92b0427f53b4d249e408253cc39f5d42020-05-01T00:00:00Zhttps://www.dovepress.com/prevalence-and-determinants-of-long-term-utilization-of-antidepressant-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Carlotta Lunghi,1– 3 Ippazio Cosimo Antonazzo,2 Sofia Burato,2 Emanuel Raschi,2 Violetta Zoffoli,2 Emanuele Forcesi,2 Elisa Sangiorgi,4 Marco Menchetti,5 Pasquale Roberge,3,6 Elisabetta Poluzzi2 1Department of Health Sciences, Université Du Québec À Rimouski, Lévis, Québec, Canada; 2Department of Medical and Surgical Sciences, Pharmacology Unit, Alma Mater Studiorum, University of Bologna, Bologna, Italy; 3Groupe De Recherche PRIMUS, Centre De Recherche Du CHUS, Université De Sherbrooke, Sherbrooke, Canada; 4Drug Policy Service, Emilia Romagna Region Health Authority, Bologna, Italy; 5Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy; 6Faculty of Medicine and Health Sciences, Université De Sherbrooke, Sherbrooke, Québec, CanadaCorrespondence: Carlotta LunghiDepartment of Health Sciences, Université Du Québec À Rimouski, 1595 Boulevard Alphonse Desjardins, Lévis, Québec G6V 0A6, CanadaTel +1 418-833-8800 Ext. 3275Email Carlotta_Lunghi@uqar.caPurpose: Antidepressant consumption has risen in recent years, driven by longer treatment duration. The objective of this study was to measure the prevalence of antidepressant long-term and chronic use in the Bologna area, Italy, and to identify their main determinants.Materials and Methods: We conducted a retrospective claims-based cohort study by using the Bologna Local Health Authority data. A cohort of 18,307 incident users of antidepressant drugs in 2013 was selected, and subjects were followed for three years. A long-term utilization was defined as having at least one prescription claimed during each year of follow-up, while chronic utilization was defined as claiming at least 180 defined daily doses per year. Factors associated with chronic and long-term use were identified by univariate and multivariate logistic regressions.Results: In our cohort, 5448 (29.8%) and 1817 (9.9%) subjects were dispensed antidepressants for a long-term course and in a chronically way, respectively. Older age, antidepressant polytherapy, polypharmacy, and being prescribed the first antidepressant by a hospital physician were all factors independently associated with chronic and long-term prescriptions of antidepressant drugs. Results were reported separately for men and women.Conclusion: Antidepressant long-term and chronic prescriptions are common in the Bologna area. Because longer treatment should be clinically motivated, these results strongly prompt the need to evaluate the actual relevance, as they may indicate potentially inappropriate prescription patterns.Keywords: antidepressants, depression, anxiety, anxiety disorders, primary care, pharmacotherapy, adherence, epidemiology, pharmacoepidemiology, treatmentLunghi CAntonazzo ICBurato SRaschi EZoffoli VForcesi ESangiorgi EMenchetti MRoberge PPoluzzi EDove Medical Pressarticleantidepressantsdepressionanxiety/anxiety disordersprimary carepharmacotherapyadherenceepidemiologypharmacoepidemiologytreatment.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1157-1170 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	antidepressants depression anxiety/anxiety disorders primary care pharmacotherapy adherence epidemiology pharmacoepidemiology treatment. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	antidepressants depression anxiety/anxiety disorders primary care pharmacotherapy adherence epidemiology pharmacoepidemiology treatment. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lunghi C Antonazzo IC Burato S Raschi E Zoffoli V Forcesi E Sangiorgi E Menchetti M Roberge P Poluzzi E Prevalence and Determinants of Long-Term Utilization of Antidepressant Drugs: A Retrospective Cohort Study
description	Carlotta Lunghi,1– 3 Ippazio Cosimo Antonazzo,2 Sofia Burato,2 Emanuel Raschi,2 Violetta Zoffoli,2 Emanuele Forcesi,2 Elisa Sangiorgi,4 Marco Menchetti,5 Pasquale Roberge,3,6 Elisabetta Poluzzi2 1Department of Health Sciences, Université Du Québec À Rimouski, Lévis, Québec, Canada; 2Department of Medical and Surgical Sciences, Pharmacology Unit, Alma Mater Studiorum, University of Bologna, Bologna, Italy; 3Groupe De Recherche PRIMUS, Centre De Recherche Du CHUS, Université De Sherbrooke, Sherbrooke, Canada; 4Drug Policy Service, Emilia Romagna Region Health Authority, Bologna, Italy; 5Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy; 6Faculty of Medicine and Health Sciences, Université De Sherbrooke, Sherbrooke, Québec, CanadaCorrespondence: Carlotta LunghiDepartment of Health Sciences, Université Du Québec À Rimouski, 1595 Boulevard Alphonse Desjardins, Lévis, Québec G6V 0A6, CanadaTel +1 418-833-8800 Ext. 3275Email Carlotta_Lunghi@uqar.caPurpose: Antidepressant consumption has risen in recent years, driven by longer treatment duration. The objective of this study was to measure the prevalence of antidepressant long-term and chronic use in the Bologna area, Italy, and to identify their main determinants.Materials and Methods: We conducted a retrospective claims-based cohort study by using the Bologna Local Health Authority data. A cohort of 18,307 incident users of antidepressant drugs in 2013 was selected, and subjects were followed for three years. A long-term utilization was defined as having at least one prescription claimed during each year of follow-up, while chronic utilization was defined as claiming at least 180 defined daily doses per year. Factors associated with chronic and long-term use were identified by univariate and multivariate logistic regressions.Results: In our cohort, 5448 (29.8%) and 1817 (9.9%) subjects were dispensed antidepressants for a long-term course and in a chronically way, respectively. Older age, antidepressant polytherapy, polypharmacy, and being prescribed the first antidepressant by a hospital physician were all factors independently associated with chronic and long-term prescriptions of antidepressant drugs. Results were reported separately for men and women.Conclusion: Antidepressant long-term and chronic prescriptions are common in the Bologna area. Because longer treatment should be clinically motivated, these results strongly prompt the need to evaluate the actual relevance, as they may indicate potentially inappropriate prescription patterns.Keywords: antidepressants, depression, anxiety, anxiety disorders, primary care, pharmacotherapy, adherence, epidemiology, pharmacoepidemiology, treatment
format	article
author	Lunghi C Antonazzo IC Burato S Raschi E Zoffoli V Forcesi E Sangiorgi E Menchetti M Roberge P Poluzzi E
author_facet	Lunghi C Antonazzo IC Burato S Raschi E Zoffoli V Forcesi E Sangiorgi E Menchetti M Roberge P Poluzzi E
author_sort	Lunghi C
title	Prevalence and Determinants of Long-Term Utilization of Antidepressant Drugs: A Retrospective Cohort Study
title_short	Prevalence and Determinants of Long-Term Utilization of Antidepressant Drugs: A Retrospective Cohort Study
title_full	Prevalence and Determinants of Long-Term Utilization of Antidepressant Drugs: A Retrospective Cohort Study
title_fullStr	Prevalence and Determinants of Long-Term Utilization of Antidepressant Drugs: A Retrospective Cohort Study
title_full_unstemmed	Prevalence and Determinants of Long-Term Utilization of Antidepressant Drugs: A Retrospective Cohort Study
title_sort	prevalence and determinants of long-term utilization of antidepressant drugs: a retrospective cohort study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e92b0427f53b4d249e408253cc39f5d4
work_keys_str_mv	AT lunghic prevalenceanddeterminantsoflongtermutilizationofantidepressantdrugsaretrospectivecohortstudy AT antonazzoic prevalenceanddeterminantsoflongtermutilizationofantidepressantdrugsaretrospectivecohortstudy AT buratos prevalenceanddeterminantsoflongtermutilizationofantidepressantdrugsaretrospectivecohortstudy AT raschie prevalenceanddeterminantsoflongtermutilizationofantidepressantdrugsaretrospectivecohortstudy AT zoffoliv prevalenceanddeterminantsoflongtermutilizationofantidepressantdrugsaretrospectivecohortstudy AT forcesie prevalenceanddeterminantsoflongtermutilizationofantidepressantdrugsaretrospectivecohortstudy AT sangiorgie prevalenceanddeterminantsoflongtermutilizationofantidepressantdrugsaretrospectivecohortstudy AT menchettim prevalenceanddeterminantsoflongtermutilizationofantidepressantdrugsaretrospectivecohortstudy AT robergep prevalenceanddeterminantsoflongtermutilizationofantidepressantdrugsaretrospectivecohortstudy AT poluzzie prevalenceanddeterminantsoflongtermutilizationofantidepressantdrugsaretrospectivecohortstudy
_version_	1718397675995398144

Prevalence and Determinants of Long-Term Utilization of Antidepressant Drugs: A Retrospective Cohort Study

Ejemplares similares