A platform for the remote conduct of gene-environment interaction studies.

<h4>Background</h4>Gene-environment interaction studies offer the prospect of robust causal inference through both gene identification and instrumental variable approaches. As such they are a major and much needed development. However, conducting these studies using traditional methods,...

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Autores principales:	John Gallacher, Rory Collins, Paul Elliott, Stephen Palmer, Paul Burton, Clive Mitchell, Gareth John, Ronan Lyons
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e92fe62bddc04f308da1fe95e4b80598
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spelling	oai:doaj.org-article:e92fe62bddc04f308da1fe95e4b805982021-11-18T08:00:52ZA platform for the remote conduct of gene-environment interaction studies.1932-620310.1371/journal.pone.0054331https://doaj.org/article/e92fe62bddc04f308da1fe95e4b805982013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23349852/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Gene-environment interaction studies offer the prospect of robust causal inference through both gene identification and instrumental variable approaches. As such they are a major and much needed development. However, conducting these studies using traditional methods, which require direct participant contact, is resource intensive. The ability to conduct gene-environment interaction studies remotely would reduce costs and increase capacity.<h4>Aim</h4>To develop a platform for the remote conduct of gene-environment interaction studies.<h4>Methods</h4>A random sample of 15,000 men and women aged 50+ years and living in Cardiff, South Wales, of whom 6,012 were estimated to have internet connectivity, were mailed inviting them to visit a web-site to join a study of successful ageing. Online consent was obtained for questionnaire completion, cognitive testing, re-contact, record linkage and genotyping. Cognitive testing was conducted using the Cardiff Cognitive Battery. Bio-sampling was randomised to blood spot, buccal cell or no request.<h4>Results</h4>A heterogeneous sample of 663 (4.5% of mailed sample and 11% of internet connected sample) men and women (47% female) aged 50-87 years (median=61 yrs) from diverse backgrounds (representing the full range of deprivation scores) was recruited. Bio-samples were donated by 70% of those agreeing to do so. Self report questionnaires and cognitive tests showed comparable distributions to those collected using face-to-face methods. Record linkage was achieved for 99.9% of participants.<h4>Conclusion</h4>This study has demonstrated that remote methods are suitable for the conduct of gene-environment interaction studies. Up-scaling these methods provides the opportunity to increase capacity for large-scale gene-environment interaction studies.John GallacherRory CollinsPaul ElliottStephen PalmerPaul BurtonClive MitchellGareth JohnRonan LyonsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54331 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q John Gallacher Rory Collins Paul Elliott Stephen Palmer Paul Burton Clive Mitchell Gareth John Ronan Lyons A platform for the remote conduct of gene-environment interaction studies.
description	<h4>Background</h4>Gene-environment interaction studies offer the prospect of robust causal inference through both gene identification and instrumental variable approaches. As such they are a major and much needed development. However, conducting these studies using traditional methods, which require direct participant contact, is resource intensive. The ability to conduct gene-environment interaction studies remotely would reduce costs and increase capacity.<h4>Aim</h4>To develop a platform for the remote conduct of gene-environment interaction studies.<h4>Methods</h4>A random sample of 15,000 men and women aged 50+ years and living in Cardiff, South Wales, of whom 6,012 were estimated to have internet connectivity, were mailed inviting them to visit a web-site to join a study of successful ageing. Online consent was obtained for questionnaire completion, cognitive testing, re-contact, record linkage and genotyping. Cognitive testing was conducted using the Cardiff Cognitive Battery. Bio-sampling was randomised to blood spot, buccal cell or no request.<h4>Results</h4>A heterogeneous sample of 663 (4.5% of mailed sample and 11% of internet connected sample) men and women (47% female) aged 50-87 years (median=61 yrs) from diverse backgrounds (representing the full range of deprivation scores) was recruited. Bio-samples were donated by 70% of those agreeing to do so. Self report questionnaires and cognitive tests showed comparable distributions to those collected using face-to-face methods. Record linkage was achieved for 99.9% of participants.<h4>Conclusion</h4>This study has demonstrated that remote methods are suitable for the conduct of gene-environment interaction studies. Up-scaling these methods provides the opportunity to increase capacity for large-scale gene-environment interaction studies.
format	article
author	John Gallacher Rory Collins Paul Elliott Stephen Palmer Paul Burton Clive Mitchell Gareth John Ronan Lyons
author_facet	John Gallacher Rory Collins Paul Elliott Stephen Palmer Paul Burton Clive Mitchell Gareth John Ronan Lyons
author_sort	John Gallacher
title	A platform for the remote conduct of gene-environment interaction studies.
title_short	A platform for the remote conduct of gene-environment interaction studies.
title_full	A platform for the remote conduct of gene-environment interaction studies.
title_fullStr	A platform for the remote conduct of gene-environment interaction studies.
title_full_unstemmed	A platform for the remote conduct of gene-environment interaction studies.
title_sort	platform for the remote conduct of gene-environment interaction studies.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e92fe62bddc04f308da1fe95e4b80598
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A platform for the remote conduct of gene-environment interaction studies.

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