G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

ATRX deficiency is linked to genomic stability in cancer cells. Here, the authors show that ATRX inactivation induces G-quadruplex formation, leading to genome-wide DNA damage, and the use of G-quadruplex stabilisers can be exploited therapeutically in ATRX deficient gliomas.

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Autores principales:	Yuxiang Wang, Jie Yang, Aaron T. Wild, Wei H. Wu, Rachna Shah, Carla Danussi, Gregory J. Riggins, Kasthuri Kannan, Erik P. Sulman, Timothy A. Chan, Jason T. Huse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e932ee13e3f2482abf203bff31b2b9b3
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spelling	oai:doaj.org-article:e932ee13e3f2482abf203bff31b2b9b32021-12-02T16:50:58ZG-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma10.1038/s41467-019-08905-82041-1723https://doaj.org/article/e932ee13e3f2482abf203bff31b2b9b32019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08905-8https://doaj.org/toc/2041-1723ATRX deficiency is linked to genomic stability in cancer cells. Here, the authors show that ATRX inactivation induces G-quadruplex formation, leading to genome-wide DNA damage, and the use of G-quadruplex stabilisers can be exploited therapeutically in ATRX deficient gliomas.Yuxiang WangJie YangAaron T. WildWei H. WuRachna ShahCarla DanussiGregory J. RigginsKasthuri KannanErik P. SulmanTimothy A. ChanJason T. HuseNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuxiang Wang Jie Yang Aaron T. Wild Wei H. Wu Rachna Shah Carla Danussi Gregory J. Riggins Kasthuri Kannan Erik P. Sulman Timothy A. Chan Jason T. Huse G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
description	ATRX deficiency is linked to genomic stability in cancer cells. Here, the authors show that ATRX inactivation induces G-quadruplex formation, leading to genome-wide DNA damage, and the use of G-quadruplex stabilisers can be exploited therapeutically in ATRX deficient gliomas.
format	article
author	Yuxiang Wang Jie Yang Aaron T. Wild Wei H. Wu Rachna Shah Carla Danussi Gregory J. Riggins Kasthuri Kannan Erik P. Sulman Timothy A. Chan Jason T. Huse
author_facet	Yuxiang Wang Jie Yang Aaron T. Wild Wei H. Wu Rachna Shah Carla Danussi Gregory J. Riggins Kasthuri Kannan Erik P. Sulman Timothy A. Chan Jason T. Huse
author_sort	Yuxiang Wang
title	G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
title_short	G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
title_full	G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
title_fullStr	G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
title_full_unstemmed	G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
title_sort	g-quadruplex dna drives genomic instability and represents a targetable molecular abnormality in atrx-deficient malignant glioma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e932ee13e3f2482abf203bff31b2b9b3
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G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

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