Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels

Loss of function of Nav1.7 leads to congenital insensitivity to pain in humans. Here the authors found that activation of Nav1.9 can restore nociception in Nav1.7 knockout mice, revealed by a venom-derived peptide as a probe.

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Autores principales:	Xi Zhou, Tingbin Ma, Luyao Yang, Shuijiao Peng, Lulu Li, Zhouquan Wang, Zhen Xiao, Qingfeng Zhang, Li Wang, Yazhou Huang, Minzhi Chen, Songping Liang, Xianwei Zhang, Jing Yu Liu, Zhonghua Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e93339c156fa489c94f4b1e344ea1aaf
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spelling	oai:doaj.org-article:e93339c156fa489c94f4b1e344ea1aaf2021-12-02T16:49:47ZSpider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels10.1038/s41467-020-16210-y2041-1723https://doaj.org/article/e93339c156fa489c94f4b1e344ea1aaf2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16210-yhttps://doaj.org/toc/2041-1723Loss of function of Nav1.7 leads to congenital insensitivity to pain in humans. Here the authors found that activation of Nav1.9 can restore nociception in Nav1.7 knockout mice, revealed by a venom-derived peptide as a probe.Xi ZhouTingbin MaLuyao YangShuijiao PengLulu LiZhouquan WangZhen XiaoQingfeng ZhangLi WangYazhou HuangMinzhi ChenSongping LiangXianwei ZhangJing Yu LiuZhonghua LiuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xi Zhou Tingbin Ma Luyao Yang Shuijiao Peng Lulu Li Zhouquan Wang Zhen Xiao Qingfeng Zhang Li Wang Yazhou Huang Minzhi Chen Songping Liang Xianwei Zhang Jing Yu Liu Zhonghua Liu Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels
description	Loss of function of Nav1.7 leads to congenital insensitivity to pain in humans. Here the authors found that activation of Nav1.9 can restore nociception in Nav1.7 knockout mice, revealed by a venom-derived peptide as a probe.
format	article
author	Xi Zhou Tingbin Ma Luyao Yang Shuijiao Peng Lulu Li Zhouquan Wang Zhen Xiao Qingfeng Zhang Li Wang Yazhou Huang Minzhi Chen Songping Liang Xianwei Zhang Jing Yu Liu Zhonghua Liu
author_facet	Xi Zhou Tingbin Ma Luyao Yang Shuijiao Peng Lulu Li Zhouquan Wang Zhen Xiao Qingfeng Zhang Li Wang Yazhou Huang Minzhi Chen Songping Liang Xianwei Zhang Jing Yu Liu Zhonghua Liu
author_sort	Xi Zhou
title	Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels
title_short	Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels
title_full	Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels
title_fullStr	Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels
title_full_unstemmed	Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels
title_sort	spider venom-derived peptide induces hyperalgesia in nav1.7 knockout mice by activating nav1.9 channels
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e93339c156fa489c94f4b1e344ea1aaf
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Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels

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