MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

Oncogene addiction is considered as a cancer cell-autonomous phenomenon, but can also influence the host immune system. Here the authors show that MYC-driven lymphomagenesis is associated with a block in the maturation and effector functions of natural killer cells as a mechanism of tumor escape fro...

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Autores principales:	Srividya Swaminathan, Aida S. Hansen, Line D. Heftdal, Renumathy Dhanasekaran, Anja Deutzmann, Wadie D. M. Fernandez, Daniel F. Liefwalker, Crista Horton, Adriane Mosley, Mariola Liebersbach, Holden T. Maecker, Dean W. Felsher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e934ba6da0f2436b96b15ce1e0b4094b
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spelling	oai:doaj.org-article:e934ba6da0f2436b96b15ce1e0b4094b2021-12-02T18:24:49ZMYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies10.1038/s41467-020-16447-72041-1723https://doaj.org/article/e934ba6da0f2436b96b15ce1e0b4094b2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16447-7https://doaj.org/toc/2041-1723Oncogene addiction is considered as a cancer cell-autonomous phenomenon, but can also influence the host immune system. Here the authors show that MYC-driven lymphomagenesis is associated with a block in the maturation and effector functions of natural killer cells as a mechanism of tumor escape from immunosurveillance.Srividya SwaminathanAida S. HansenLine D. HeftdalRenumathy DhanasekaranAnja DeutzmannWadie D. M. FernandezDaniel F. LiefwalkerCrista HortonAdriane MosleyMariola LiebersbachHolden T. MaeckerDean W. FelsherNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Srividya Swaminathan Aida S. Hansen Line D. Heftdal Renumathy Dhanasekaran Anja Deutzmann Wadie D. M. Fernandez Daniel F. Liefwalker Crista Horton Adriane Mosley Mariola Liebersbach Holden T. Maecker Dean W. Felsher MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies
description	Oncogene addiction is considered as a cancer cell-autonomous phenomenon, but can also influence the host immune system. Here the authors show that MYC-driven lymphomagenesis is associated with a block in the maturation and effector functions of natural killer cells as a mechanism of tumor escape from immunosurveillance.
format	article
author	Srividya Swaminathan Aida S. Hansen Line D. Heftdal Renumathy Dhanasekaran Anja Deutzmann Wadie D. M. Fernandez Daniel F. Liefwalker Crista Horton Adriane Mosley Mariola Liebersbach Holden T. Maecker Dean W. Felsher
author_facet	Srividya Swaminathan Aida S. Hansen Line D. Heftdal Renumathy Dhanasekaran Anja Deutzmann Wadie D. M. Fernandez Daniel F. Liefwalker Crista Horton Adriane Mosley Mariola Liebersbach Holden T. Maecker Dean W. Felsher
author_sort	Srividya Swaminathan
title	MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies
title_short	MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies
title_full	MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies
title_fullStr	MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies
title_full_unstemmed	MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies
title_sort	myc functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e934ba6da0f2436b96b15ce1e0b4094b
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MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

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