Prevalence of diabetes and obesity in association with prematurity and growth restriction

Gretchen Kopec, Prem S Shekhawat, Maroun J Mhanna Department of Pediatrics, MetroHealth Medical Centre, Case Western Reserve University, Cleveland, OH, USA Abstract: Intrauterine growth restriction (IUGR) is when fetuses and newborn infants have not reached their true growth potent...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kopec G, Shekhawat PS, Mhanna MJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Diabetes Obesity Low Birth Weight Infants Metabolic syndrome Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/e9358e0b38434abab4376627298b0ee3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e9358e0b38434abab4376627298b0ee3
record_format	dspace
spelling	oai:doaj.org-article:e9358e0b38434abab4376627298b0ee32021-12-02T00:09:48ZPrevalence of diabetes and obesity in association with prematurity and growth restriction1178-7007https://doaj.org/article/e9358e0b38434abab4376627298b0ee32017-07-01T00:00:00Zhttps://www.dovepress.com/prevalence-of-diabetes-and-obesity-in-association-with-prematurity-and-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Gretchen Kopec, Prem S Shekhawat, Maroun J Mhanna Department of Pediatrics, MetroHealth Medical Centre, Case Western Reserve University, Cleveland, OH, USA Abstract: Intrauterine growth restriction (IUGR) is when fetuses and newborn infants have not reached their true growth potential as genetically defined. Fetuses with IUGR develop in a less than ideal environment that leads to epigenetic changes and marks infants’ metabolism for the rest of their lives. Epigenetic changes affect insulin-like growth factor-1 (IGF-1) levels and lead to insulin resistance and ultimately to a metabolic syndrome. The metabolic syndrome is a constellation of illnesses that raise one’s risk for type 2 diabetes mellitus, coronary artery disease, and ischemic heart disease, including hypertension, dyslipidemia, central obesity, insulin resistance, and inflammation. The association between IUGR or prematurity and long-term insulin resistance, obesity, hypertension, and metabolic syndrome remains unclear. While studies have shown an association, others have not supported such association. If alteration of intrauterine growth can ultimately lead to the development of metabolic derangements in childhood and adulthood, and if such association is true, then early interventions targeting the health of pregnant women will ensure the health of the population to follow. Keywords: diabetes, obesity, low birth weight infants, metabolic syndromeKopec GShekhawat PSMhanna MJDove Medical PressarticleDiabetesObesityLow Birth Weight InfantsMetabolic syndromeSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 10, Pp 285-295 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diabetes Obesity Low Birth Weight Infants Metabolic syndrome Specialties of internal medicine RC581-951
spellingShingle	Diabetes Obesity Low Birth Weight Infants Metabolic syndrome Specialties of internal medicine RC581-951 Kopec G Shekhawat PS Mhanna MJ Prevalence of diabetes and obesity in association with prematurity and growth restriction
description	Gretchen Kopec, Prem S Shekhawat, Maroun J Mhanna Department of Pediatrics, MetroHealth Medical Centre, Case Western Reserve University, Cleveland, OH, USA Abstract: Intrauterine growth restriction (IUGR) is when fetuses and newborn infants have not reached their true growth potential as genetically defined. Fetuses with IUGR develop in a less than ideal environment that leads to epigenetic changes and marks infants’ metabolism for the rest of their lives. Epigenetic changes affect insulin-like growth factor-1 (IGF-1) levels and lead to insulin resistance and ultimately to a metabolic syndrome. The metabolic syndrome is a constellation of illnesses that raise one’s risk for type 2 diabetes mellitus, coronary artery disease, and ischemic heart disease, including hypertension, dyslipidemia, central obesity, insulin resistance, and inflammation. The association between IUGR or prematurity and long-term insulin resistance, obesity, hypertension, and metabolic syndrome remains unclear. While studies have shown an association, others have not supported such association. If alteration of intrauterine growth can ultimately lead to the development of metabolic derangements in childhood and adulthood, and if such association is true, then early interventions targeting the health of pregnant women will ensure the health of the population to follow. Keywords: diabetes, obesity, low birth weight infants, metabolic syndrome
format	article
author	Kopec G Shekhawat PS Mhanna MJ
author_facet	Kopec G Shekhawat PS Mhanna MJ
author_sort	Kopec G
title	Prevalence of diabetes and obesity in association with prematurity and growth restriction
title_short	Prevalence of diabetes and obesity in association with prematurity and growth restriction
title_full	Prevalence of diabetes and obesity in association with prematurity and growth restriction
title_fullStr	Prevalence of diabetes and obesity in association with prematurity and growth restriction
title_full_unstemmed	Prevalence of diabetes and obesity in association with prematurity and growth restriction
title_sort	prevalence of diabetes and obesity in association with prematurity and growth restriction
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/e9358e0b38434abab4376627298b0ee3
work_keys_str_mv	AT kopecg prevalenceofdiabetesandobesityinassociationwithprematurityandgrowthrestriction AT shekhawatps prevalenceofdiabetesandobesityinassociationwithprematurityandgrowthrestriction AT mhannamj prevalenceofdiabetesandobesityinassociationwithprematurityandgrowthrestriction
_version_	1718403958219735040

Prevalence of diabetes and obesity in association with prematurity and growth restriction

Ejemplares similares