Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype

The molecular basis of the clinically important MAM blood group antigen present in most humans is unknown. We identify EMP3 as its encoding gene, establishing MAM as a new blood group system, and demonstrate the role of EMP3 in erythropoiesis through its interaction with the signalling molecule CD44...

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Autores principales:	Nicole Thornton, Vanja Karamatic Crew, Louise Tilley, Carole A. Green, Chwen Ling Tay, Rebecca E. Griffiths, Belinda K. Singleton, Frances Spring, Piers Walser, Abdul Ghani Alattar, Benjamin Jones, Rosalind Laundy, Jill R. Storry, Mattias Möller, Lorna Wall, Richard Charlewood, Connie M. Westhoff, Christine Lomas-Francis, Vered Yahalom, Ute Feick, Axel Seltsam, Beate Mayer, Martin L. Olsson, David J. Anstee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e938a7d9bc5f42fa84a3d130a0d92402
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spelling	oai:doaj.org-article:e938a7d9bc5f42fa84a3d130a0d924022021-12-02T16:08:14ZDisruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype10.1038/s41467-020-17060-42041-1723https://doaj.org/article/e938a7d9bc5f42fa84a3d130a0d924022020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17060-4https://doaj.org/toc/2041-1723The molecular basis of the clinically important MAM blood group antigen present in most humans is unknown. We identify EMP3 as its encoding gene, establishing MAM as a new blood group system, and demonstrate the role of EMP3 in erythropoiesis through its interaction with the signalling molecule CD44.Nicole ThorntonVanja Karamatic CrewLouise TilleyCarole A. GreenChwen Ling TayRebecca E. GriffithsBelinda K. SingletonFrances SpringPiers WalserAbdul Ghani AlattarBenjamin JonesRosalind LaundyJill R. StorryMattias MöllerLorna WallRichard CharlewoodConnie M. WesthoffChristine Lomas-FrancisVered YahalomUte FeickAxel SeltsamBeate MayerMartin L. OlssonDavid J. AnsteeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicole Thornton Vanja Karamatic Crew Louise Tilley Carole A. Green Chwen Ling Tay Rebecca E. Griffiths Belinda K. Singleton Frances Spring Piers Walser Abdul Ghani Alattar Benjamin Jones Rosalind Laundy Jill R. Storry Mattias Möller Lorna Wall Richard Charlewood Connie M. Westhoff Christine Lomas-Francis Vered Yahalom Ute Feick Axel Seltsam Beate Mayer Martin L. Olsson David J. Anstee Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype
description	The molecular basis of the clinically important MAM blood group antigen present in most humans is unknown. We identify EMP3 as its encoding gene, establishing MAM as a new blood group system, and demonstrate the role of EMP3 in erythropoiesis through its interaction with the signalling molecule CD44.
format	article
author	Nicole Thornton Vanja Karamatic Crew Louise Tilley Carole A. Green Chwen Ling Tay Rebecca E. Griffiths Belinda K. Singleton Frances Spring Piers Walser Abdul Ghani Alattar Benjamin Jones Rosalind Laundy Jill R. Storry Mattias Möller Lorna Wall Richard Charlewood Connie M. Westhoff Christine Lomas-Francis Vered Yahalom Ute Feick Axel Seltsam Beate Mayer Martin L. Olsson David J. Anstee
author_facet	Nicole Thornton Vanja Karamatic Crew Louise Tilley Carole A. Green Chwen Ling Tay Rebecca E. Griffiths Belinda K. Singleton Frances Spring Piers Walser Abdul Ghani Alattar Benjamin Jones Rosalind Laundy Jill R. Storry Mattias Möller Lorna Wall Richard Charlewood Connie M. Westhoff Christine Lomas-Francis Vered Yahalom Ute Feick Axel Seltsam Beate Mayer Martin L. Olsson David J. Anstee
author_sort	Nicole Thornton
title	Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype
title_short	Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype
title_full	Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype
title_fullStr	Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype
title_full_unstemmed	Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype
title_sort	disruption of the tumour-associated emp3 enhances erythroid proliferation and causes the mam-negative phenotype
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e938a7d9bc5f42fa84a3d130a0d92402
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Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype

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