Molecular layer interneurons in the cerebellum encode for valence in associative learning

This study shows that cerebellar molecular layer interneurons (MLIs) develop responses encoding for identity of the stimulus in an associative learning task. Chemogenetic inhibition of MLIs decreased the ability of mice to discriminate stimuli suggesting that MLIs encode for stimulus valence.

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Detalles Bibliográficos
Autores principales: Ming Ma, Gregory L. Futia, Fabio M. Simoes de Souza, Baris N. Ozbay, Isabel Llano, Emily A. Gibson, Diego Restrepo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/e939dd0379a7491e9b71c703b9d39a49
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Descripción
Sumario:This study shows that cerebellar molecular layer interneurons (MLIs) develop responses encoding for identity of the stimulus in an associative learning task. Chemogenetic inhibition of MLIs decreased the ability of mice to discriminate stimuli suggesting that MLIs encode for stimulus valence.