Molecular layer interneurons in the cerebellum encode for valence in associative learning

This study shows that cerebellar molecular layer interneurons (MLIs) develop responses encoding for identity of the stimulus in an associative learning task. Chemogenetic inhibition of MLIs decreased the ability of mice to discriminate stimuli suggesting that MLIs encode for stimulus valence.

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Autores principales:	Ming Ma, Gregory L. Futia, Fabio M. Simoes de Souza, Baris N. Ozbay, Isabel Llano, Emily A. Gibson, Diego Restrepo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e939dd0379a7491e9b71c703b9d39a49
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spelling	oai:doaj.org-article:e939dd0379a7491e9b71c703b9d39a492021-12-02T15:25:36ZMolecular layer interneurons in the cerebellum encode for valence in associative learning10.1038/s41467-020-18034-22041-1723https://doaj.org/article/e939dd0379a7491e9b71c703b9d39a492020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18034-2https://doaj.org/toc/2041-1723This study shows that cerebellar molecular layer interneurons (MLIs) develop responses encoding for identity of the stimulus in an associative learning task. Chemogenetic inhibition of MLIs decreased the ability of mice to discriminate stimuli suggesting that MLIs encode for stimulus valence.Ming MaGregory L. FutiaFabio M. Simoes de SouzaBaris N. OzbayIsabel LlanoEmily A. GibsonDiego RestrepoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ming Ma Gregory L. Futia Fabio M. Simoes de Souza Baris N. Ozbay Isabel Llano Emily A. Gibson Diego Restrepo Molecular layer interneurons in the cerebellum encode for valence in associative learning
description	This study shows that cerebellar molecular layer interneurons (MLIs) develop responses encoding for identity of the stimulus in an associative learning task. Chemogenetic inhibition of MLIs decreased the ability of mice to discriminate stimuli suggesting that MLIs encode for stimulus valence.
format	article
author	Ming Ma Gregory L. Futia Fabio M. Simoes de Souza Baris N. Ozbay Isabel Llano Emily A. Gibson Diego Restrepo
author_facet	Ming Ma Gregory L. Futia Fabio M. Simoes de Souza Baris N. Ozbay Isabel Llano Emily A. Gibson Diego Restrepo
author_sort	Ming Ma
title	Molecular layer interneurons in the cerebellum encode for valence in associative learning
title_short	Molecular layer interneurons in the cerebellum encode for valence in associative learning
title_full	Molecular layer interneurons in the cerebellum encode for valence in associative learning
title_fullStr	Molecular layer interneurons in the cerebellum encode for valence in associative learning
title_full_unstemmed	Molecular layer interneurons in the cerebellum encode for valence in associative learning
title_sort	molecular layer interneurons in the cerebellum encode for valence in associative learning
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e939dd0379a7491e9b71c703b9d39a49
work_keys_str_mv	AT mingma molecularlayerinterneuronsinthecerebellumencodeforvalenceinassociativelearning AT gregorylfutia molecularlayerinterneuronsinthecerebellumencodeforvalenceinassociativelearning AT fabiomsimoesdesouza molecularlayerinterneuronsinthecerebellumencodeforvalenceinassociativelearning AT barisnozbay molecularlayerinterneuronsinthecerebellumencodeforvalenceinassociativelearning AT isabelllano molecularlayerinterneuronsinthecerebellumencodeforvalenceinassociativelearning AT emilyagibson molecularlayerinterneuronsinthecerebellumencodeforvalenceinassociativelearning AT diegorestrepo molecularlayerinterneuronsinthecerebellumencodeforvalenceinassociativelearning
_version_	1718387238013763584

Molecular layer interneurons in the cerebellum encode for valence in associative learning

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