Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma

Abstract Perineural invasion (PNI) is frequently associated with aggressive clinical behaviour in head and neck cutaneous squamous cell carcinoma (HNcSCC) leading to local recurrence and treatment failure. This study evaluates the gene expression profiles of HNcSCC with PNI using a differential expr...

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Autores principales:	Timothy J. Eviston, Elahe Minaei, Simon A. Mueller, Navid Ahmadi, Bruce Ashford, Jonathan R. Clark, Nicholas West, Ping Zhang, Ruta Gupta, Marie Ranson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e93b3721fd0e471c9554e026e51d6ffd
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spelling	oai:doaj.org-article:e93b3721fd0e471c9554e026e51d6ffd2021-12-02T17:44:54ZGene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma10.1038/s41598-021-92335-42045-2322https://doaj.org/article/e93b3721fd0e471c9554e026e51d6ffd2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92335-4https://doaj.org/toc/2045-2322Abstract Perineural invasion (PNI) is frequently associated with aggressive clinical behaviour in head and neck cutaneous squamous cell carcinoma (HNcSCC) leading to local recurrence and treatment failure. This study evaluates the gene expression profiles of HNcSCC with PNI using a differential expression analysis approach and constructs a tailored gene panel for sensitivity and specificity analysis. 45 cases of HNcSCC were stratified into three groups (Extensive, Focal and Non PNI) based on predefined clinicopathological criteria. Here we show HNcSCC with extensive PNI demonstrates significant up- and down-regulation of 144 genes associated with extracellular matrix interactions, epithelial to mesenchymal transition, cell adhesion, cellular motility, angiogenesis, and cellular differentiation. Gene expression of focal and non PNI cohorts were indistinguishable and were combined for further analyses. There is clinicopathological correlation between gene expression analysis findings and disease behaviour and a tailored panel of 10 genes was able to identify extensive PNI with 96% sensitivity and 95% specificity.Timothy J. EvistonElahe MinaeiSimon A. MuellerNavid AhmadiBruce AshfordJonathan R. ClarkNicholas WestPing ZhangRuta GuptaMarie RansonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Timothy J. Eviston Elahe Minaei Simon A. Mueller Navid Ahmadi Bruce Ashford Jonathan R. Clark Nicholas West Ping Zhang Ruta Gupta Marie Ranson Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma
description	Abstract Perineural invasion (PNI) is frequently associated with aggressive clinical behaviour in head and neck cutaneous squamous cell carcinoma (HNcSCC) leading to local recurrence and treatment failure. This study evaluates the gene expression profiles of HNcSCC with PNI using a differential expression analysis approach and constructs a tailored gene panel for sensitivity and specificity analysis. 45 cases of HNcSCC were stratified into three groups (Extensive, Focal and Non PNI) based on predefined clinicopathological criteria. Here we show HNcSCC with extensive PNI demonstrates significant up- and down-regulation of 144 genes associated with extracellular matrix interactions, epithelial to mesenchymal transition, cell adhesion, cellular motility, angiogenesis, and cellular differentiation. Gene expression of focal and non PNI cohorts were indistinguishable and were combined for further analyses. There is clinicopathological correlation between gene expression analysis findings and disease behaviour and a tailored panel of 10 genes was able to identify extensive PNI with 96% sensitivity and 95% specificity.
format	article
author	Timothy J. Eviston Elahe Minaei Simon A. Mueller Navid Ahmadi Bruce Ashford Jonathan R. Clark Nicholas West Ping Zhang Ruta Gupta Marie Ranson
author_facet	Timothy J. Eviston Elahe Minaei Simon A. Mueller Navid Ahmadi Bruce Ashford Jonathan R. Clark Nicholas West Ping Zhang Ruta Gupta Marie Ranson
author_sort	Timothy J. Eviston
title	Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma
title_short	Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma
title_full	Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma
title_fullStr	Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma
title_full_unstemmed	Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma
title_sort	gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e93b3721fd0e471c9554e026e51d6ffd
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Gene expression profiling of perineural invasion in head and neck cutaneous squamous cell carcinoma

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