A biopotential optrode array: operation principles and simulations

Abstract We propose an optical electrode ’optrode’ sensor array for biopotential measurements. The transduction mechanism is based on deformed helix ferroelectric liquid crystals which realign, altering the optrode’s light reflectance properties, relative to applied potential fields of biological ce...

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Autores principales:	Amr Al Abed, Hrishikesh Srinivas, Josiah Firth, François Ladouceur, Nigel H. Lovell, Leonardo Silvestri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e93b9bd01c724a949669ad35b777e33a
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spelling	oai:doaj.org-article:e93b9bd01c724a949669ad35b777e33a2021-12-02T15:09:11ZA biopotential optrode array: operation principles and simulations10.1038/s41598-018-20182-x2045-2322https://doaj.org/article/e93b9bd01c724a949669ad35b777e33a2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-20182-xhttps://doaj.org/toc/2045-2322Abstract We propose an optical electrode ’optrode’ sensor array for biopotential measurements. The transduction mechanism is based on deformed helix ferroelectric liquid crystals which realign, altering the optrode’s light reflectance properties, relative to applied potential fields of biological cells and tissue. A computational model of extracellular potential recording by the optrode including the electro-optical transduction mechanism is presented, using a combination of time-domain and frequency-domain finite element analysis. Simulations indicate that the device has appropriate temporal response to faithfully transduce neuronal spikes, and spatial resolution to capture impulse propagation along a single neuron. These simulations contribute to the development of multi-channel optrode arrays for spatio-temporal mapping of electric events in excitable biological tissue.Amr Al AbedHrishikesh SrinivasJosiah FirthFrançois LadouceurNigel H. LovellLeonardo SilvestriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amr Al Abed Hrishikesh Srinivas Josiah Firth François Ladouceur Nigel H. Lovell Leonardo Silvestri A biopotential optrode array: operation principles and simulations
description	Abstract We propose an optical electrode ’optrode’ sensor array for biopotential measurements. The transduction mechanism is based on deformed helix ferroelectric liquid crystals which realign, altering the optrode’s light reflectance properties, relative to applied potential fields of biological cells and tissue. A computational model of extracellular potential recording by the optrode including the electro-optical transduction mechanism is presented, using a combination of time-domain and frequency-domain finite element analysis. Simulations indicate that the device has appropriate temporal response to faithfully transduce neuronal spikes, and spatial resolution to capture impulse propagation along a single neuron. These simulations contribute to the development of multi-channel optrode arrays for spatio-temporal mapping of electric events in excitable biological tissue.
format	article
author	Amr Al Abed Hrishikesh Srinivas Josiah Firth François Ladouceur Nigel H. Lovell Leonardo Silvestri
author_facet	Amr Al Abed Hrishikesh Srinivas Josiah Firth François Ladouceur Nigel H. Lovell Leonardo Silvestri
author_sort	Amr Al Abed
title	A biopotential optrode array: operation principles and simulations
title_short	A biopotential optrode array: operation principles and simulations
title_full	A biopotential optrode array: operation principles and simulations
title_fullStr	A biopotential optrode array: operation principles and simulations
title_full_unstemmed	A biopotential optrode array: operation principles and simulations
title_sort	biopotential optrode array: operation principles and simulations
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e93b9bd01c724a949669ad35b777e33a
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A biopotential optrode array: operation principles and simulations

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