Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population

Abstract This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and...

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Autores principales:	Juncheol Lee, Bongyoung Kim, Wonhee Kim, Chiwon Ahn, Hyun Young Choi, Jae Guk Kim, Jihoon Kim, Hyungoo Shin, Jun Goo Kang, Shinje Moon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e93c1e25fd2a4e9bbd371bb541cf9e0d
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spelling	oai:doaj.org-article:e93c1e25fd2a4e9bbd371bb541cf9e0d2021-12-02T13:23:58ZLipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population10.1038/s41598-021-82053-22045-2322https://doaj.org/article/e93c1e25fd2a4e9bbd371bb541cf9e0d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82053-2https://doaj.org/toc/2045-2322Abstract This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff values. This cross-sectional study used the data of 11,378 adults, derived from the United States National Health and Nutrition Examination Survey (1999–2016). Insulin resistance was defined as a homeostasis model assessment-insulin resistance value above the 75th percentile for each sex and race/ethnicities. The area under the curves (AUCs) were as follows: VAI, 0.735; LAP, 0.796; TyG index, 0.723; TyG-BMI, 0.823, and; TyG-WC, 0.822. The AUCs for TyG-BMI and TyG-WC were significantly higher than those for VAI, LAP, and TyG index (vs. TyG-BMI, p < 0.001; vs. TyG-WC, p < 0.001). The cutoff values were as follows: VAI: men 1.65, women 1.65; LAP: men 42.5, women 42.5; TyG index: men 4.665, women 4.575; TyG-BMI: men 135.5, women 135.5; and TyG-WC: men 461.5, women 440.5. Given that lipid indices can be easily calculated with routine laboratory tests, these values may be useful markers for insulin resistance risk assessments in clinical settings.Juncheol LeeBongyoung KimWonhee KimChiwon AhnHyun Young ChoiJae Guk KimJihoon KimHyungoo ShinJun Goo KangShinje MoonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juncheol Lee Bongyoung Kim Wonhee Kim Chiwon Ahn Hyun Young Choi Jae Guk Kim Jihoon Kim Hyungoo Shin Jun Goo Kang Shinje Moon Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population
description	Abstract This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff values. This cross-sectional study used the data of 11,378 adults, derived from the United States National Health and Nutrition Examination Survey (1999–2016). Insulin resistance was defined as a homeostasis model assessment-insulin resistance value above the 75th percentile for each sex and race/ethnicities. The area under the curves (AUCs) were as follows: VAI, 0.735; LAP, 0.796; TyG index, 0.723; TyG-BMI, 0.823, and; TyG-WC, 0.822. The AUCs for TyG-BMI and TyG-WC were significantly higher than those for VAI, LAP, and TyG index (vs. TyG-BMI, p < 0.001; vs. TyG-WC, p < 0.001). The cutoff values were as follows: VAI: men 1.65, women 1.65; LAP: men 42.5, women 42.5; TyG index: men 4.665, women 4.575; TyG-BMI: men 135.5, women 135.5; and TyG-WC: men 461.5, women 440.5. Given that lipid indices can be easily calculated with routine laboratory tests, these values may be useful markers for insulin resistance risk assessments in clinical settings.
format	article
author	Juncheol Lee Bongyoung Kim Wonhee Kim Chiwon Ahn Hyun Young Choi Jae Guk Kim Jihoon Kim Hyungoo Shin Jun Goo Kang Shinje Moon
author_facet	Juncheol Lee Bongyoung Kim Wonhee Kim Chiwon Ahn Hyun Young Choi Jae Guk Kim Jihoon Kim Hyungoo Shin Jun Goo Kang Shinje Moon
author_sort	Juncheol Lee
title	Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population
title_short	Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population
title_full	Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population
title_fullStr	Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population
title_full_unstemmed	Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population
title_sort	lipid indices as simple and clinically useful surrogate markers for insulin resistance in the u.s. population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e93c1e25fd2a4e9bbd371bb541cf9e0d
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Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population

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