Infection-derived lipids elicit an immune deficiency circuit in arthropods

The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless.

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Auteurs principaux:	Dana K. Shaw, Xiaowei Wang, Lindsey J. Brown, Adela S. Oliva Chávez, Kathryn E. Reif, Alexis A. Smith, Alison J. Scott, Erin E. McClure, Vishant M. Boradia, Holly L. Hammond, Eric J. Sundberg, Greg A. Snyder, Lei Liu, Kathleen DePonte, Margarita Villar, Massaro W. Ueti, José de la Fuente, Robert K. Ernst, Utpal Pal, Erol Fikrig, Joao H. F. Pedra
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e93ff65b05c44e12b7a08eacf7918704
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spelling	oai:doaj.org-article:e93ff65b05c44e12b7a08eacf79187042021-12-02T14:42:09ZInfection-derived lipids elicit an immune deficiency circuit in arthropods10.1038/ncomms144012041-1723https://doaj.org/article/e93ff65b05c44e12b7a08eacf79187042017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14401https://doaj.org/toc/2041-1723The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless.Dana K. ShawXiaowei WangLindsey J. BrownAdela S. Oliva ChávezKathryn E. ReifAlexis A. SmithAlison J. ScottErin E. McClureVishant M. BoradiaHolly L. HammondEric J. SundbergGreg A. SnyderLei LiuKathleen DePonteMargarita VillarMassaro W. UetiJosé de la FuenteRobert K. ErnstUtpal PalErol FikrigJoao H. F. PedraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dana K. Shaw Xiaowei Wang Lindsey J. Brown Adela S. Oliva Chávez Kathryn E. Reif Alexis A. Smith Alison J. Scott Erin E. McClure Vishant M. Boradia Holly L. Hammond Eric J. Sundberg Greg A. Snyder Lei Liu Kathleen DePonte Margarita Villar Massaro W. Ueti José de la Fuente Robert K. Ernst Utpal Pal Erol Fikrig Joao H. F. Pedra Infection-derived lipids elicit an immune deficiency circuit in arthropods
description	The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless.
format	article
author	Dana K. Shaw Xiaowei Wang Lindsey J. Brown Adela S. Oliva Chávez Kathryn E. Reif Alexis A. Smith Alison J. Scott Erin E. McClure Vishant M. Boradia Holly L. Hammond Eric J. Sundberg Greg A. Snyder Lei Liu Kathleen DePonte Margarita Villar Massaro W. Ueti José de la Fuente Robert K. Ernst Utpal Pal Erol Fikrig Joao H. F. Pedra
author_facet	Dana K. Shaw Xiaowei Wang Lindsey J. Brown Adela S. Oliva Chávez Kathryn E. Reif Alexis A. Smith Alison J. Scott Erin E. McClure Vishant M. Boradia Holly L. Hammond Eric J. Sundberg Greg A. Snyder Lei Liu Kathleen DePonte Margarita Villar Massaro W. Ueti José de la Fuente Robert K. Ernst Utpal Pal Erol Fikrig Joao H. F. Pedra
author_sort	Dana K. Shaw
title	Infection-derived lipids elicit an immune deficiency circuit in arthropods
title_short	Infection-derived lipids elicit an immune deficiency circuit in arthropods
title_full	Infection-derived lipids elicit an immune deficiency circuit in arthropods
title_fullStr	Infection-derived lipids elicit an immune deficiency circuit in arthropods
title_full_unstemmed	Infection-derived lipids elicit an immune deficiency circuit in arthropods
title_sort	infection-derived lipids elicit an immune deficiency circuit in arthropods
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e93ff65b05c44e12b7a08eacf7918704
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Infection-derived lipids elicit an immune deficiency circuit in arthropods

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