Infection-derived lipids elicit an immune deficiency circuit in arthropods
The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless.
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Nature Portfolio
2017
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| Acceso en línea: | https://doaj.org/article/e93ff65b05c44e12b7a08eacf7918704 |
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oai:doaj.org-article:e93ff65b05c44e12b7a08eacf79187042021-12-02T14:42:09ZInfection-derived lipids elicit an immune deficiency circuit in arthropods10.1038/ncomms144012041-1723https://doaj.org/article/e93ff65b05c44e12b7a08eacf79187042017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14401https://doaj.org/toc/2041-1723The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless.Dana K. ShawXiaowei WangLindsey J. BrownAdela S. Oliva ChávezKathryn E. ReifAlexis A. SmithAlison J. ScottErin E. McClureVishant M. BoradiaHolly L. HammondEric J. SundbergGreg A. SnyderLei LiuKathleen DePonteMargarita VillarMassaro W. UetiJosé de la FuenteRobert K. ErnstUtpal PalErol FikrigJoao H. F. PedraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Dana K. Shaw Xiaowei Wang Lindsey J. Brown Adela S. Oliva Chávez Kathryn E. Reif Alexis A. Smith Alison J. Scott Erin E. McClure Vishant M. Boradia Holly L. Hammond Eric J. Sundberg Greg A. Snyder Lei Liu Kathleen DePonte Margarita Villar Massaro W. Ueti José de la Fuente Robert K. Ernst Utpal Pal Erol Fikrig Joao H. F. Pedra Infection-derived lipids elicit an immune deficiency circuit in arthropods |
| description |
The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless. |
| format |
article |
| author |
Dana K. Shaw Xiaowei Wang Lindsey J. Brown Adela S. Oliva Chávez Kathryn E. Reif Alexis A. Smith Alison J. Scott Erin E. McClure Vishant M. Boradia Holly L. Hammond Eric J. Sundberg Greg A. Snyder Lei Liu Kathleen DePonte Margarita Villar Massaro W. Ueti José de la Fuente Robert K. Ernst Utpal Pal Erol Fikrig Joao H. F. Pedra |
| author_facet |
Dana K. Shaw Xiaowei Wang Lindsey J. Brown Adela S. Oliva Chávez Kathryn E. Reif Alexis A. Smith Alison J. Scott Erin E. McClure Vishant M. Boradia Holly L. Hammond Eric J. Sundberg Greg A. Snyder Lei Liu Kathleen DePonte Margarita Villar Massaro W. Ueti José de la Fuente Robert K. Ernst Utpal Pal Erol Fikrig Joao H. F. Pedra |
| author_sort |
Dana K. Shaw |
| title |
Infection-derived lipids elicit an immune deficiency circuit in arthropods |
| title_short |
Infection-derived lipids elicit an immune deficiency circuit in arthropods |
| title_full |
Infection-derived lipids elicit an immune deficiency circuit in arthropods |
| title_fullStr |
Infection-derived lipids elicit an immune deficiency circuit in arthropods |
| title_full_unstemmed |
Infection-derived lipids elicit an immune deficiency circuit in arthropods |
| title_sort |
infection-derived lipids elicit an immune deficiency circuit in arthropods |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/e93ff65b05c44e12b7a08eacf7918704 |
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