TUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C

Abstract. Participation of pro- and anti-inflammatory cytokines in pathogenesis of inflammation and fibrosis served as a basis for studying TNFα and TGFβ levels in blood serum from the patients with chronic hepatitis C (CHC), as compared with modes and degree of patho-morphological changes in liver...

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Autores principales:	T. V. Antonova, N. L. Shironina, N. A. Gavrisheva, T. P. Ses
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	hepatitis c fibrosis tnfα tgfβ Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e940138591c24c03a81c50d8f6fc0c55
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spelling	oai:doaj.org-article:e940138591c24c03a81c50d8f6fc0c552021-11-18T08:03:39ZTUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C1563-06252313-741X10.15789/1563-0625-2007-4-5-499-504https://doaj.org/article/e940138591c24c03a81c50d8f6fc0c552014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/226https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Participation of pro- and anti-inflammatory cytokines in pathogenesis of inflammation and fibrosis served as a basis for studying TNFα and TGFβ levels in blood serum from the patients with chronic hepatitis C (CHC), as compared with modes and degree of patho-morphological changes in liver biopsies. We have detected a sufficient increase in serum TGFβ levels from patients in sub-clinical stage of CHC, independent on activity of the inflammatory process and expression of fibrosis, with a trend for its higher levels in cases of clinical decompensation at cirrhotic stage of the disease. Ambiguous changes of TNFα indexes in CHC patients with a tendency of higher levels in cases of higher histological activity and fibrosis of liver tissue allow us to consider a possible correlation with varying degree of compensatory and adaptive reactions.T. V. AntonovaN. L. ShironinaN. A. GavrishevaT. P. SesSPb RAACIarticlehepatitis cfibrosistnfαtgfβImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 9, Iss 4-5, Pp 499-504 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hepatitis c fibrosis tnfα tgfβ Immunologic diseases. Allergy RC581-607
spellingShingle	hepatitis c fibrosis tnfα tgfβ Immunologic diseases. Allergy RC581-607 T. V. Antonova N. L. Shironina N. A. Gavrisheva T. P. Ses TUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C
description	Abstract. Participation of pro- and anti-inflammatory cytokines in pathogenesis of inflammation and fibrosis served as a basis for studying TNFα and TGFβ levels in blood serum from the patients with chronic hepatitis C (CHC), as compared with modes and degree of patho-morphological changes in liver biopsies. We have detected a sufficient increase in serum TGFβ levels from patients in sub-clinical stage of CHC, independent on activity of the inflammatory process and expression of fibrosis, with a trend for its higher levels in cases of clinical decompensation at cirrhotic stage of the disease. Ambiguous changes of TNFα indexes in CHC patients with a tendency of higher levels in cases of higher histological activity and fibrosis of liver tissue allow us to consider a possible correlation with varying degree of compensatory and adaptive reactions.
format	article
author	T. V. Antonova N. L. Shironina N. A. Gavrisheva T. P. Ses
author_facet	T. V. Antonova N. L. Shironina N. A. Gavrisheva T. P. Ses
author_sort	T. V. Antonova
title	TUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C
title_short	TUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C
title_full	TUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C
title_fullStr	TUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C
title_full_unstemmed	TUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C
title_sort	tumor necrosis and transforming growth factors level in sub-clinical stage of chronic hepatitis c
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/e940138591c24c03a81c50d8f6fc0c55
work_keys_str_mv	AT tvantonova tumornecrosisandtransforminggrowthfactorslevelinsubclinicalstageofchronichepatitisc AT nlshironina tumornecrosisandtransforminggrowthfactorslevelinsubclinicalstageofchronichepatitisc AT nagavrisheva tumornecrosisandtransforminggrowthfactorslevelinsubclinicalstageofchronichepatitisc AT tpses tumornecrosisandtransforminggrowthfactorslevelinsubclinicalstageofchronichepatitisc
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TUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C

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