Influence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model

Abstract Intraoperative indocyanine green (ICG) fluorescence angiography has gained popularity and acceptance in many surgical fields for the real-time assessment of tissue perfusion. Although vasopressors have the potential to preclude an accurate assessment of tissue perfusion, there is a lack of...

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Autores principales:	Mahdi Al-Taher, Tim Pruimboom, Rutger M. Schols, Nariaki Okamoto, Nicole D. Bouvy, Laurents P. S. Stassen, René R. W. J. van der Hulst, Michael Kugler, Alexandre Hostettler, Eric Noll, Jacques Marescaux, Sophie Diemunsch, Michele Diana
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e944fad2fb354d03afad5e64991e3fa6
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spelling	oai:doaj.org-article:e944fad2fb354d03afad5e64991e3fa62021-12-02T14:49:43ZInfluence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model10.1038/s41598-021-89223-22045-2322https://doaj.org/article/e944fad2fb354d03afad5e64991e3fa62021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89223-2https://doaj.org/toc/2045-2322Abstract Intraoperative indocyanine green (ICG) fluorescence angiography has gained popularity and acceptance in many surgical fields for the real-time assessment of tissue perfusion. Although vasopressors have the potential to preclude an accurate assessment of tissue perfusion, there is a lack of literature with regards to its effect on ICG fluorescence angiography. An experimental porcine model was used to expose the small bowel for quantitative tissue perfusion assessment. Three increasing doses of norepinephrine infusion (0.1, 0.5, and 1.0 µg/kg/min) were administered intravenously over a 25-min interval. Time-to-peak fluorescence intensity (TTP) was the primary outcome. Secondary outcomes included absolute fluorescence intensity and local capillary lactate (LCL) levels. Five large pigs (mean weight: 40.3 ± 4.24 kg) were included. There was no significant difference in mean TTP (in seconds) at baseline (4.23) as compared to the second (3.90), third (4.41), fourth (4.60), and fifth ICG assessment (5.99). As a result of ICG accumulation, the mean and the maximum absolute fluorescence intensity were significantly different as compared to the baseline assessment. There was no significant difference in LCL levels (in mmol/L) at baseline (0.74) as compared to the second (0.82), third (0.64), fourth (0.60), and fifth assessment (0.62). Increasing doses of norepinephrine infusion have no significant influence on bowel perfusion using ICG fluorescence angiography.Mahdi Al-TaherTim PruimboomRutger M. ScholsNariaki OkamotoNicole D. BouvyLaurents P. S. StassenRené R. W. J. van der HulstMichael KuglerAlexandre HostettlerEric NollJacques MarescauxSophie DiemunschMichele DianaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mahdi Al-Taher Tim Pruimboom Rutger M. Schols Nariaki Okamoto Nicole D. Bouvy Laurents P. S. Stassen René R. W. J. van der Hulst Michael Kugler Alexandre Hostettler Eric Noll Jacques Marescaux Sophie Diemunsch Michele Diana Influence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model
description	Abstract Intraoperative indocyanine green (ICG) fluorescence angiography has gained popularity and acceptance in many surgical fields for the real-time assessment of tissue perfusion. Although vasopressors have the potential to preclude an accurate assessment of tissue perfusion, there is a lack of literature with regards to its effect on ICG fluorescence angiography. An experimental porcine model was used to expose the small bowel for quantitative tissue perfusion assessment. Three increasing doses of norepinephrine infusion (0.1, 0.5, and 1.0 µg/kg/min) were administered intravenously over a 25-min interval. Time-to-peak fluorescence intensity (TTP) was the primary outcome. Secondary outcomes included absolute fluorescence intensity and local capillary lactate (LCL) levels. Five large pigs (mean weight: 40.3 ± 4.24 kg) were included. There was no significant difference in mean TTP (in seconds) at baseline (4.23) as compared to the second (3.90), third (4.41), fourth (4.60), and fifth ICG assessment (5.99). As a result of ICG accumulation, the mean and the maximum absolute fluorescence intensity were significantly different as compared to the baseline assessment. There was no significant difference in LCL levels (in mmol/L) at baseline (0.74) as compared to the second (0.82), third (0.64), fourth (0.60), and fifth assessment (0.62). Increasing doses of norepinephrine infusion have no significant influence on bowel perfusion using ICG fluorescence angiography.
format	article
author	Mahdi Al-Taher Tim Pruimboom Rutger M. Schols Nariaki Okamoto Nicole D. Bouvy Laurents P. S. Stassen René R. W. J. van der Hulst Michael Kugler Alexandre Hostettler Eric Noll Jacques Marescaux Sophie Diemunsch Michele Diana
author_facet	Mahdi Al-Taher Tim Pruimboom Rutger M. Schols Nariaki Okamoto Nicole D. Bouvy Laurents P. S. Stassen René R. W. J. van der Hulst Michael Kugler Alexandre Hostettler Eric Noll Jacques Marescaux Sophie Diemunsch Michele Diana
author_sort	Mahdi Al-Taher
title	Influence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model
title_short	Influence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model
title_full	Influence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model
title_fullStr	Influence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model
title_full_unstemmed	Influence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model
title_sort	influence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e944fad2fb354d03afad5e64991e3fa6
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Influence of intraoperative vasopressor use on indocyanine green fluorescence angiography: first evaluation in an experimental model

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