Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking

The dose conformity of carbon-ion beam radiotherapy, which allows the reduction of the dose deposition in healthy tissue and the escalation of the dose to the tumor, is associated with a high sensitivity to anatomical changes during and between treatment irradiations. Thus, the monitoring of inter-f...

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Autores principales:	Laura Ghesquière-Diérickx, Annika Schlechter, Renato Félix-Bautista, Tim Gehrke, Gernot Echner, Laurent Kelleter, Mária Martišíková
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	carbon-ion radiotherapy in-vivo treatment monitoring inter-fractional anatomical changes secondary-ion tracking beam fragmentation silicon pixel detector Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e9455f4ae4a94465abad1e7875eb2805
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spelling	oai:doaj.org-article:e9455f4ae4a94465abad1e7875eb28052021-12-01T12:16:41ZInvestigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking2234-943X10.3389/fonc.2021.780221https://doaj.org/article/e9455f4ae4a94465abad1e7875eb28052021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.780221/fullhttps://doaj.org/toc/2234-943XThe dose conformity of carbon-ion beam radiotherapy, which allows the reduction of the dose deposition in healthy tissue and the escalation of the dose to the tumor, is associated with a high sensitivity to anatomical changes during and between treatment irradiations. Thus, the monitoring of inter-fractional anatomical changes is crucial to ensure the dose conformity, to potentially reduce the size of the safety margins around the tumor and ultimately to reduce the irradiation of healthy tissue. To do so, monitoring methods of carbon-ion radiotherapy in depth using secondary-ion tracking are being investigated. In this work, the detection and localization of a small air cavity of 2 mm thickness were investigated at different detection angles of the mini-tracker relative to the beam axis. The experiments were conducted with a PMMA head phantom at the Heidelberg Ion-Beam Therapy Center (HIT) in Germany. In a clinic-like irradiation of a single field of 3 Gy (RBE), secondary-ion emission profiles were measured by a 2 cm2 mini-tracker composed of two silicon pixel detectors. Two positions of the cavity in the head phantom were studied: in front and in the middle of the tumor volume. The significance of the cavity detection was found to be increased at smaller detection angles, while the accuracy of the cavity localization was improved at larger detection angles. Detection angles of 20° – 30° were found to be a good compromise for accessing both, the detectability and the position of the air cavity along the depth in the head of a patient.Laura Ghesquière-DiérickxLaura Ghesquière-DiérickxLaura Ghesquière-DiérickxAnnika SchlechterAnnika SchlechterAnnika SchlechterRenato Félix-BautistaRenato Félix-BautistaRenato Félix-BautistaTim GehrkeTim GehrkeGernot EchnerGernot EchnerLaurent KelleterLaurent KelleterMária MartišíkováMária MartišíkováFrontiers Media S.A.articlecarbon-ion radiotherapyin-vivo treatment monitoringinter-fractional anatomical changessecondary-ion trackingbeam fragmentationsilicon pixel detectorNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	carbon-ion radiotherapy in-vivo treatment monitoring inter-fractional anatomical changes secondary-ion tracking beam fragmentation silicon pixel detector Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	carbon-ion radiotherapy in-vivo treatment monitoring inter-fractional anatomical changes secondary-ion tracking beam fragmentation silicon pixel detector Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Laura Ghesquière-Diérickx Laura Ghesquière-Diérickx Laura Ghesquière-Diérickx Annika Schlechter Annika Schlechter Annika Schlechter Renato Félix-Bautista Renato Félix-Bautista Renato Félix-Bautista Tim Gehrke Tim Gehrke Gernot Echner Gernot Echner Laurent Kelleter Laurent Kelleter Mária Martišíková Mária Martišíková Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking
description	The dose conformity of carbon-ion beam radiotherapy, which allows the reduction of the dose deposition in healthy tissue and the escalation of the dose to the tumor, is associated with a high sensitivity to anatomical changes during and between treatment irradiations. Thus, the monitoring of inter-fractional anatomical changes is crucial to ensure the dose conformity, to potentially reduce the size of the safety margins around the tumor and ultimately to reduce the irradiation of healthy tissue. To do so, monitoring methods of carbon-ion radiotherapy in depth using secondary-ion tracking are being investigated. In this work, the detection and localization of a small air cavity of 2 mm thickness were investigated at different detection angles of the mini-tracker relative to the beam axis. The experiments were conducted with a PMMA head phantom at the Heidelberg Ion-Beam Therapy Center (HIT) in Germany. In a clinic-like irradiation of a single field of 3 Gy (RBE), secondary-ion emission profiles were measured by a 2 cm2 mini-tracker composed of two silicon pixel detectors. Two positions of the cavity in the head phantom were studied: in front and in the middle of the tumor volume. The significance of the cavity detection was found to be increased at smaller detection angles, while the accuracy of the cavity localization was improved at larger detection angles. Detection angles of 20° – 30° were found to be a good compromise for accessing both, the detectability and the position of the air cavity along the depth in the head of a patient.
format	article
author	Laura Ghesquière-Diérickx Laura Ghesquière-Diérickx Laura Ghesquière-Diérickx Annika Schlechter Annika Schlechter Annika Schlechter Renato Félix-Bautista Renato Félix-Bautista Renato Félix-Bautista Tim Gehrke Tim Gehrke Gernot Echner Gernot Echner Laurent Kelleter Laurent Kelleter Mária Martišíková Mária Martišíková
author_facet	Laura Ghesquière-Diérickx Laura Ghesquière-Diérickx Laura Ghesquière-Diérickx Annika Schlechter Annika Schlechter Annika Schlechter Renato Félix-Bautista Renato Félix-Bautista Renato Félix-Bautista Tim Gehrke Tim Gehrke Gernot Echner Gernot Echner Laurent Kelleter Laurent Kelleter Mária Martišíková Mária Martišíková
author_sort	Laura Ghesquière-Diérickx
title	Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking
title_short	Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking
title_full	Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking
title_fullStr	Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking
title_full_unstemmed	Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking
title_sort	investigation of suitable detection angles for carbon-ion radiotherapy monitoring in depth by means of secondary-ion tracking
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e9455f4ae4a94465abad1e7875eb2805
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Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking

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