Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer

Bladder cancer is one of the most common and highly vascularized cancers. Here the authors perform a whole-genome analysis in urothelial bladder carcinomas and identify recurrent genetic alterations in a set of angiogenesis genes, facilitating the understanding of molecular mechanisms underlying pat...

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Autores principales:	Song Wu, Tong Ou, Nianzeng Xing, Jiang Lu, Shengqing Wan, Changxi Wang, Xi Zhang, Feiya Yang, Yi Huang, Zhiming Cai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9480435b64d444b8ae4cdedd63584ba
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spelling	oai:doaj.org-article:e9480435b64d444b8ae4cdedd63584ba2021-12-02T16:57:35ZWhole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer10.1038/s41467-019-08576-52041-1723https://doaj.org/article/e9480435b64d444b8ae4cdedd63584ba2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08576-5https://doaj.org/toc/2041-1723Bladder cancer is one of the most common and highly vascularized cancers. Here the authors perform a whole-genome analysis in urothelial bladder carcinomas and identify recurrent genetic alterations in a set of angiogenesis genes, facilitating the understanding of molecular mechanisms underlying pathological angiogenesis in this type of cancer.Song WuTong OuNianzeng XingJiang LuShengqing WanChangxi WangXi ZhangFeiya YangYi HuangZhiming CaiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Song Wu Tong Ou Nianzeng Xing Jiang Lu Shengqing Wan Changxi Wang Xi Zhang Feiya Yang Yi Huang Zhiming Cai Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
description	Bladder cancer is one of the most common and highly vascularized cancers. Here the authors perform a whole-genome analysis in urothelial bladder carcinomas and identify recurrent genetic alterations in a set of angiogenesis genes, facilitating the understanding of molecular mechanisms underlying pathological angiogenesis in this type of cancer.
format	article
author	Song Wu Tong Ou Nianzeng Xing Jiang Lu Shengqing Wan Changxi Wang Xi Zhang Feiya Yang Yi Huang Zhiming Cai
author_facet	Song Wu Tong Ou Nianzeng Xing Jiang Lu Shengqing Wan Changxi Wang Xi Zhang Feiya Yang Yi Huang Zhiming Cai
author_sort	Song Wu
title	Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
title_short	Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
title_full	Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
title_fullStr	Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
title_full_unstemmed	Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
title_sort	whole-genome sequencing identifies adgrg6 enhancer mutations and frs2 duplications as angiogenesis-related drivers in bladder cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e9480435b64d444b8ae4cdedd63584ba
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Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer

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