Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm

Abstract This study aimed to evaluate the long-term visual outcomes of hemorrhagic retinal arterial macroaneurysm (RAM), particularly focusing on the influence of bevacizumab therapy and intraretinal hemorrhage (IRH) on the outcomes. This retrospective study included 49 patients diagnosed with hemor...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Jae Hui Kim, Jong Woo Kim, Chul Gu Kim, Young Ju Lew, Han Joo Cho
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
R
Q
Acceso en línea:https://doaj.org/article/e9480ff379644011874b97969c1e8f2b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:e9480ff379644011874b97969c1e8f2b
record_format dspace
spelling oai:doaj.org-article:e9480ff379644011874b97969c1e8f2b2021-12-02T15:23:07ZInfluence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm10.1038/s41598-021-93811-72045-2322https://doaj.org/article/e9480ff379644011874b97969c1e8f2b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93811-7https://doaj.org/toc/2045-2322Abstract This study aimed to evaluate the long-term visual outcomes of hemorrhagic retinal arterial macroaneurysm (RAM), particularly focusing on the influence of bevacizumab therapy and intraretinal hemorrhage (IRH) on the outcomes. This retrospective study included 49 patients diagnosed with hemorrhagic RAM. Patients were divided into the bevacizumab group and observation group depending on the whether they were administered bevacizumab treatment and the IRH group and the non-IRH group based on the presence of IRH at the fovea. Best-corrected visual acuity (BCVA) at diagnosis was compared with that at the final visit. Further, the BCVA at the final visit was compared between the study groups. Multivariate analysis was also performed to identify factors associated with poor BCVA at the final visit. The mean follow-up period was 24.8 ± 15.3 months. The mean logarithm of minimal angle of resolution BCVA was significantly improved from 1.37 ± 0.70 at diagnosis to 0.72 ± 0.62 at the final visit (P < 0.001). There was no significant difference in the BCVA at the final visit between the bevacizumab group and observation group (P = 0.576). However, the BCVA at the final visit was significantly worse in the IRH group than in the non-IRH group (P = 0.002). In multivariate analysis, the presence of IRH was significantly associated with poor BCVA (P = 0.007). Significant long-term visual improvement was noted in hemorrhagic RAM. However, the presence of IRH at the fovea was associated with poor visual prognosis. Bevacizumab therapy did not significantly influence the outcomes.Jae Hui KimJong Woo KimChul Gu KimYoung Ju LewHan Joo ChoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Jae Hui Kim
Jong Woo Kim
Chul Gu Kim
Young Ju Lew
Han Joo Cho
Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm
description Abstract This study aimed to evaluate the long-term visual outcomes of hemorrhagic retinal arterial macroaneurysm (RAM), particularly focusing on the influence of bevacizumab therapy and intraretinal hemorrhage (IRH) on the outcomes. This retrospective study included 49 patients diagnosed with hemorrhagic RAM. Patients were divided into the bevacizumab group and observation group depending on the whether they were administered bevacizumab treatment and the IRH group and the non-IRH group based on the presence of IRH at the fovea. Best-corrected visual acuity (BCVA) at diagnosis was compared with that at the final visit. Further, the BCVA at the final visit was compared between the study groups. Multivariate analysis was also performed to identify factors associated with poor BCVA at the final visit. The mean follow-up period was 24.8 ± 15.3 months. The mean logarithm of minimal angle of resolution BCVA was significantly improved from 1.37 ± 0.70 at diagnosis to 0.72 ± 0.62 at the final visit (P < 0.001). There was no significant difference in the BCVA at the final visit between the bevacizumab group and observation group (P = 0.576). However, the BCVA at the final visit was significantly worse in the IRH group than in the non-IRH group (P = 0.002). In multivariate analysis, the presence of IRH was significantly associated with poor BCVA (P = 0.007). Significant long-term visual improvement was noted in hemorrhagic RAM. However, the presence of IRH at the fovea was associated with poor visual prognosis. Bevacizumab therapy did not significantly influence the outcomes.
format article
author Jae Hui Kim
Jong Woo Kim
Chul Gu Kim
Young Ju Lew
Han Joo Cho
author_facet Jae Hui Kim
Jong Woo Kim
Chul Gu Kim
Young Ju Lew
Han Joo Cho
author_sort Jae Hui Kim
title Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm
title_short Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm
title_full Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm
title_fullStr Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm
title_full_unstemmed Influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm
title_sort influence of bevacizumab therapy and intraretinal hemorrhage in long-term outcomes of hemorrhagic retinal arterial macroaneurysm
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e9480ff379644011874b97969c1e8f2b
work_keys_str_mv AT jaehuikim influenceofbevacizumabtherapyandintraretinalhemorrhageinlongtermoutcomesofhemorrhagicretinalarterialmacroaneurysm
AT jongwookim influenceofbevacizumabtherapyandintraretinalhemorrhageinlongtermoutcomesofhemorrhagicretinalarterialmacroaneurysm
AT chulgukim influenceofbevacizumabtherapyandintraretinalhemorrhageinlongtermoutcomesofhemorrhagicretinalarterialmacroaneurysm
AT youngjulew influenceofbevacizumabtherapyandintraretinalhemorrhageinlongtermoutcomesofhemorrhagicretinalarterialmacroaneurysm
AT hanjoocho influenceofbevacizumabtherapyandintraretinalhemorrhageinlongtermoutcomesofhemorrhagicretinalarterialmacroaneurysm
_version_ 1718387359109611520