Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action.

Chagas disease is a neglected illness caused by Trypanosoma cruzi and its treatment is done only with two drugs, nifurtimox and benznidazole. However, both drugs are ineffective in the chronic phase, in addition to causing serious side effects. This context of therapeutic limitation justifies the co...

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Autores principales:	Joana D'Arc S Trindade, Célio Geraldo Freire-de-Lima, Suzana Côrte-Real, Debora Decote-Ricardo, Marco Edilson Freire de Lima
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9492448a8c743db876edc237dae20fe
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spelling	oai:doaj.org-article:e9492448a8c743db876edc237dae20fe2021-12-02T20:13:35ZDrug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action.1932-620310.1371/journal.pone.0258292https://doaj.org/article/e9492448a8c743db876edc237dae20fe2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258292https://doaj.org/toc/1932-6203Chagas disease is a neglected illness caused by Trypanosoma cruzi and its treatment is done only with two drugs, nifurtimox and benznidazole. However, both drugs are ineffective in the chronic phase, in addition to causing serious side effects. This context of therapeutic limitation justifies the continuous research for alternative drugs. Here, we study the in vitro trypanocidal effects of the non-steroidal anti-inflammatory drug nimesulide, a molecule that has in its chemical structure a toxicophoric nitroaromatic group (NO2). The set of results obtained in this work highlights the potential for repurposing nimesulide in the treatment of this disease that affects millions of people around the world.Joana D'Arc S TrindadeCélio Geraldo Freire-de-LimaSuzana Côrte-RealDebora Decote-RicardoMarco Edilson Freire de LimaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258292 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joana D'Arc S Trindade Célio Geraldo Freire-de-Lima Suzana Côrte-Real Debora Decote-Ricardo Marco Edilson Freire de Lima Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action.
description	Chagas disease is a neglected illness caused by Trypanosoma cruzi and its treatment is done only with two drugs, nifurtimox and benznidazole. However, both drugs are ineffective in the chronic phase, in addition to causing serious side effects. This context of therapeutic limitation justifies the continuous research for alternative drugs. Here, we study the in vitro trypanocidal effects of the non-steroidal anti-inflammatory drug nimesulide, a molecule that has in its chemical structure a toxicophoric nitroaromatic group (NO2). The set of results obtained in this work highlights the potential for repurposing nimesulide in the treatment of this disease that affects millions of people around the world.
format	article
author	Joana D'Arc S Trindade Célio Geraldo Freire-de-Lima Suzana Côrte-Real Debora Decote-Ricardo Marco Edilson Freire de Lima
author_facet	Joana D'Arc S Trindade Célio Geraldo Freire-de-Lima Suzana Côrte-Real Debora Decote-Ricardo Marco Edilson Freire de Lima
author_sort	Joana D'Arc S Trindade
title	Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action.
title_short	Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action.
title_full	Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action.
title_fullStr	Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action.
title_full_unstemmed	Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action.
title_sort	drug repurposing for chagas disease: in vitro assessment of nimesulide against trypanosoma cruzi and insights on its mechanisms of action.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e9492448a8c743db876edc237dae20fe
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Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action.

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