Antioxidant and Hepatoprotective Effects of Tranilast against Thioacetamide-Induced Liver Fibrosis in Rats

The aim of the present study was to investigate the potential antioxidant and Hepatoprotective activities of tranilast against TAA-induced liver fibrosis in rats. Methods: Liver fibrosis was induced in rats by intra peritoneal injection of TAA (200 mg/kg) for 6 weeks. Tranilast was administered oral...

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Autores principales:	Ramadan A., Nehal A. Afifi, Nemat Z. Yassin, Rehab F. Abdel-Rahman, Sahar S. Abd El-Rahman, Hany M. Fayed
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2017
Materias:	hepatic fibrosis thioacetamide tranilast liver rat Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://dx.doi.org/10.21608/javs.2017.62131 https://doaj.org/article/e94b12a5a6e942e4b79daf9082d98e40
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spelling	oai:doaj.org-article:e94b12a5a6e942e4b79daf9082d98e402021-12-02T17:02:54ZAntioxidant and Hepatoprotective Effects of Tranilast against Thioacetamide-Induced Liver Fibrosis in Ratshttps://dx.doi.org/10.21608/javs.2017.621311687-40722090-3308https://doaj.org/article/e94b12a5a6e942e4b79daf9082d98e402017-10-01T00:00:00Zhttps://javs.journals.ekb.eg/article_62131.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308The aim of the present study was to investigate the potential antioxidant and Hepatoprotective activities of tranilast against TAA-induced liver fibrosis in rats. Methods: Liver fibrosis was induced in rats by intra peritoneal injection of TAA (200 mg/kg) for 6 weeks. Tranilast was administered orally at a dose of 150 and 300mg/kg for 6 weeks before induction of liver fibrosis. Results: Injection of TAA induced hepatic fibrosis that was manifested by a significant increase in the activities of aminotransferases and total bilirubin with a significant decrease in total protein and albumin in serum. Liver homogenate of TAA rats had the lower content of reduced glutathione (GSH) and superoxide dismutase (SOD) with increased levels of the hepatic malondialdehyde. Histological data presented marked damage in liver sections of TAA rats. Oral dosing of tranilast for 6 weeks before induction of liver fibrosis reversed these altered parameters near to normal values. These results suggest that tranilast could afford significant protection and antioxidant effect in prevention of liver fibrosis.Ramadan A.Nehal A. Afifi Nemat Z. YassinRehab F. Abdel-Rahman Sahar S. Abd El-RahmanHany M. Fayed Egyptian Society for Animal Managementarticlehepatic fibrosisthioacetamidetranilastliverratZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 2, Iss 1, Pp 9-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatic fibrosis thioacetamide tranilast liver rat Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	hepatic fibrosis thioacetamide tranilast liver rat Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Ramadan A. Nehal A. Afifi Nemat Z. Yassin Rehab F. Abdel-Rahman Sahar S. Abd El-Rahman Hany M. Fayed Antioxidant and Hepatoprotective Effects of Tranilast against Thioacetamide-Induced Liver Fibrosis in Rats
description	The aim of the present study was to investigate the potential antioxidant and Hepatoprotective activities of tranilast against TAA-induced liver fibrosis in rats. Methods: Liver fibrosis was induced in rats by intra peritoneal injection of TAA (200 mg/kg) for 6 weeks. Tranilast was administered orally at a dose of 150 and 300mg/kg for 6 weeks before induction of liver fibrosis. Results: Injection of TAA induced hepatic fibrosis that was manifested by a significant increase in the activities of aminotransferases and total bilirubin with a significant decrease in total protein and albumin in serum. Liver homogenate of TAA rats had the lower content of reduced glutathione (GSH) and superoxide dismutase (SOD) with increased levels of the hepatic malondialdehyde. Histological data presented marked damage in liver sections of TAA rats. Oral dosing of tranilast for 6 weeks before induction of liver fibrosis reversed these altered parameters near to normal values. These results suggest that tranilast could afford significant protection and antioxidant effect in prevention of liver fibrosis.
format	article
author	Ramadan A. Nehal A. Afifi Nemat Z. Yassin Rehab F. Abdel-Rahman Sahar S. Abd El-Rahman Hany M. Fayed
author_facet	Ramadan A. Nehal A. Afifi Nemat Z. Yassin Rehab F. Abdel-Rahman Sahar S. Abd El-Rahman Hany M. Fayed
author_sort	Ramadan A.
title	Antioxidant and Hepatoprotective Effects of Tranilast against Thioacetamide-Induced Liver Fibrosis in Rats
title_short	Antioxidant and Hepatoprotective Effects of Tranilast against Thioacetamide-Induced Liver Fibrosis in Rats
title_full	Antioxidant and Hepatoprotective Effects of Tranilast against Thioacetamide-Induced Liver Fibrosis in Rats
title_fullStr	Antioxidant and Hepatoprotective Effects of Tranilast against Thioacetamide-Induced Liver Fibrosis in Rats
title_full_unstemmed	Antioxidant and Hepatoprotective Effects of Tranilast against Thioacetamide-Induced Liver Fibrosis in Rats
title_sort	antioxidant and hepatoprotective effects of tranilast against thioacetamide-induced liver fibrosis in rats
publisher	Egyptian Society for Animal Management
publishDate	2017
url	https://dx.doi.org/10.21608/javs.2017.62131 https://doaj.org/article/e94b12a5a6e942e4b79daf9082d98e40
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Antioxidant and Hepatoprotective Effects of Tranilast against Thioacetamide-Induced Liver Fibrosis in Rats

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