Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p

The heterodimeric eukaryotic Drs2p-Cdc50p complex is a lipid flippase that maintains cell membrane asymmetry and its autoinhibition is released by PI4P binding. Here authors show cryo-EM structures of Drs2p-Cdc50p in apo and PI4P-activated form which reveal the structural changes upon PI4P binding.

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Autores principales:	Lin Bai, Amanda Kovach, Qinglong You, Hao-Chi Hsu, Gongpu Zhao, Huilin Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e94c17af5f174b8bb315f2e32a1c2d9c
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spelling	oai:doaj.org-article:e94c17af5f174b8bb315f2e32a1c2d9c2021-12-02T16:57:20ZAutoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p10.1038/s41467-019-12191-92041-1723https://doaj.org/article/e94c17af5f174b8bb315f2e32a1c2d9c2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12191-9https://doaj.org/toc/2041-1723The heterodimeric eukaryotic Drs2p-Cdc50p complex is a lipid flippase that maintains cell membrane asymmetry and its autoinhibition is released by PI4P binding. Here authors show cryo-EM structures of Drs2p-Cdc50p in apo and PI4P-activated form which reveal the structural changes upon PI4P binding.Lin BaiAmanda KovachQinglong YouHao-Chi HsuGongpu ZhaoHuilin LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lin Bai Amanda Kovach Qinglong You Hao-Chi Hsu Gongpu Zhao Huilin Li Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p
description	The heterodimeric eukaryotic Drs2p-Cdc50p complex is a lipid flippase that maintains cell membrane asymmetry and its autoinhibition is released by PI4P binding. Here authors show cryo-EM structures of Drs2p-Cdc50p in apo and PI4P-activated form which reveal the structural changes upon PI4P binding.
format	article
author	Lin Bai Amanda Kovach Qinglong You Hao-Chi Hsu Gongpu Zhao Huilin Li
author_facet	Lin Bai Amanda Kovach Qinglong You Hao-Chi Hsu Gongpu Zhao Huilin Li
author_sort	Lin Bai
title	Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p
title_short	Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p
title_full	Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p
title_fullStr	Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p
title_full_unstemmed	Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p
title_sort	autoinhibition and activation mechanisms of the eukaryotic lipid flippase drs2p-cdc50p
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e94c17af5f174b8bb315f2e32a1c2d9c
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Autoinhibition and activation mechanisms of the eukaryotic lipid flippase Drs2p-Cdc50p

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