Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial

Abstract Background Supplemental oxygen delivered with standard oxygen therapy (SOT) improves exercise capacity in patients with idiopathic pulmonary fibrosis (IPF). Although high-flow nasal cannula oxygen therapy (HFNC) improves oxygenation in other respiratory diseases, its impact on exercise perf...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Diana Badenes-Bonet, Pilar Cejudo, Anna Rodó-Pin, Clara Martín-Ontiyuelo, Roberto Chalela, Jose Antonio Rodríguez-Portal, Rosa Vázquez-Sánchez, Joaquim Gea, Xavier Duran, Oswaldo Antonio Caguana, Diego Agustín Rodriguez-Chiaradia, Eva Balcells
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Idiopathic pulmonary fibrosis High-flow nasal cannula Oxygen therapy Exertional desaturation Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/e951b5575056477e81e043b7fbaa2ff2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e951b5575056477e81e043b7fbaa2ff2
record_format	dspace
spelling	oai:doaj.org-article:e951b5575056477e81e043b7fbaa2ff22021-11-14T12:37:14ZImpact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial10.1186/s12890-021-01727-91471-2466https://doaj.org/article/e951b5575056477e81e043b7fbaa2ff22021-11-01T00:00:00Zhttps://doi.org/10.1186/s12890-021-01727-9https://doaj.org/toc/1471-2466Abstract Background Supplemental oxygen delivered with standard oxygen therapy (SOT) improves exercise capacity in patients with idiopathic pulmonary fibrosis (IPF). Although high-flow nasal cannula oxygen therapy (HFNC) improves oxygenation in other respiratory diseases, its impact on exercise performance has never been evaluated in IPF patients. We hypothesized that HFNC may improve exercise capacity in IPF subjects compared to SOT. Methods This was a prospective, crossover, pilot randomized trial that compared both oxygenation methods during a constant submaximal cardiopulmonary exercise test (CPET) in IPF patients with exertional oxygen saturation (SpO2) ≤ 85% in the 6-min walking test. The primary outcome was endurance time (Tlim). Secondary outcomes were muscle oxygen saturation (StO2) and respiratory and leg symptoms. Results Ten IPF patients [71.7 (6) years old, 90% males] were included. FVC and DLCO were 58 ± 11% and 31 ± 13% pred. respectively. Tlim during CPET was significantly greater using HFNC compared to SOT [494 ± 173 vs. 381 ± 137 s, p = 0.01]. HFNC also associated with a higher increase in inspiratory capacity (IC) [19.4 ± 14.2 vs. 7.1 ± 8.9%, respectively; p = 0.04], and a similar trend was observed in StO2 during exercise. No differences were found in respiratory or leg symptoms between the two oxygen devices. Conclusions This is the first study demonstrating that HFNC oxygen therapy improves exercise tolerance better than SOT in IPF patients with exertional desaturation. This might be explained by changes in ventilatory mechanics and muscle oxygenation. Further and larger studies are needed to confirm the benefits of HFNC in IPF patients and its potential usefulness in rehabilitation programs.Diana Badenes-BonetPilar CejudoAnna Rodó-PinClara Martín-OntiyueloRoberto ChalelaJose Antonio Rodríguez-PortalRosa Vázquez-SánchezJoaquim GeaXavier DuranOswaldo Antonio CaguanaDiego Agustín Rodriguez-ChiaradiaEva BalcellsBMCarticleIdiopathic pulmonary fibrosisHigh-flow nasal cannulaOxygen therapyExertional desaturationDiseases of the respiratory systemRC705-779ENBMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Idiopathic pulmonary fibrosis High-flow nasal cannula Oxygen therapy Exertional desaturation Diseases of the respiratory system RC705-779
spellingShingle	Idiopathic pulmonary fibrosis High-flow nasal cannula Oxygen therapy Exertional desaturation Diseases of the respiratory system RC705-779 Diana Badenes-Bonet Pilar Cejudo Anna Rodó-Pin Clara Martín-Ontiyuelo Roberto Chalela Jose Antonio Rodríguez-Portal Rosa Vázquez-Sánchez Joaquim Gea Xavier Duran Oswaldo Antonio Caguana Diego Agustín Rodriguez-Chiaradia Eva Balcells Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial
description	Abstract Background Supplemental oxygen delivered with standard oxygen therapy (SOT) improves exercise capacity in patients with idiopathic pulmonary fibrosis (IPF). Although high-flow nasal cannula oxygen therapy (HFNC) improves oxygenation in other respiratory diseases, its impact on exercise performance has never been evaluated in IPF patients. We hypothesized that HFNC may improve exercise capacity in IPF subjects compared to SOT. Methods This was a prospective, crossover, pilot randomized trial that compared both oxygenation methods during a constant submaximal cardiopulmonary exercise test (CPET) in IPF patients with exertional oxygen saturation (SpO2) ≤ 85% in the 6-min walking test. The primary outcome was endurance time (Tlim). Secondary outcomes were muscle oxygen saturation (StO2) and respiratory and leg symptoms. Results Ten IPF patients [71.7 (6) years old, 90% males] were included. FVC and DLCO were 58 ± 11% and 31 ± 13% pred. respectively. Tlim during CPET was significantly greater using HFNC compared to SOT [494 ± 173 vs. 381 ± 137 s, p = 0.01]. HFNC also associated with a higher increase in inspiratory capacity (IC) [19.4 ± 14.2 vs. 7.1 ± 8.9%, respectively; p = 0.04], and a similar trend was observed in StO2 during exercise. No differences were found in respiratory or leg symptoms between the two oxygen devices. Conclusions This is the first study demonstrating that HFNC oxygen therapy improves exercise tolerance better than SOT in IPF patients with exertional desaturation. This might be explained by changes in ventilatory mechanics and muscle oxygenation. Further and larger studies are needed to confirm the benefits of HFNC in IPF patients and its potential usefulness in rehabilitation programs.
format	article
author	Diana Badenes-Bonet Pilar Cejudo Anna Rodó-Pin Clara Martín-Ontiyuelo Roberto Chalela Jose Antonio Rodríguez-Portal Rosa Vázquez-Sánchez Joaquim Gea Xavier Duran Oswaldo Antonio Caguana Diego Agustín Rodriguez-Chiaradia Eva Balcells
author_facet	Diana Badenes-Bonet Pilar Cejudo Anna Rodó-Pin Clara Martín-Ontiyuelo Roberto Chalela Jose Antonio Rodríguez-Portal Rosa Vázquez-Sánchez Joaquim Gea Xavier Duran Oswaldo Antonio Caguana Diego Agustín Rodriguez-Chiaradia Eva Balcells
author_sort	Diana Badenes-Bonet
title	Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial
title_short	Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial
title_full	Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial
title_fullStr	Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial
title_full_unstemmed	Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial
title_sort	impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e951b5575056477e81e043b7fbaa2ff2
work_keys_str_mv	AT dianabadenesbonet impactofhighflowoxygentherapyduringexerciseinidiopathicpulmonaryfibrosisapilotcrossoverclinicaltrial AT pilarcejudo impactofhighflowoxygentherapyduringexerciseinidiopathicpulmonaryfibrosisapilotcrossoverclinicaltrial AT annarodopin impactofhighflowoxygentherapyduringexerciseinidiopathicpulmonaryfibrosisapilotcrossoverclinicaltrial AT claramartinontiyuelo impactofhighflowoxygentherapyduringexerciseinidiopathicpulmonaryfibrosisapilotcrossoverclinicaltrial AT robertochalela impactofhighflowoxygentherapyduringexerciseinidiopathicpulmonaryfibrosisapilotcrossoverclinicaltrial AT joseantoniorodriguezportal impactofhighflowoxygentherapyduringexerciseinidiopathicpulmonaryfibrosisapilotcrossoverclinicaltrial AT rosavazquezsanchez impactofhighflowoxygentherapyduringexerciseinidiopathicpulmonaryfibrosisapilotcrossoverclinicaltrial AT joaquimgea impactofhighflowoxygentherapyduringexerciseinidiopathicpulmonaryfibrosisapilotcrossoverclinicaltrial AT xavierduran impactofhighflowoxygentherapyduringexerciseinidiopathicpulmonaryfibrosisapilotcrossoverclinicaltrial AT oswaldoantoniocaguana impactofhighflowoxygentherapyduringexerciseinidiopathicpulmonaryfibrosisapilotcrossoverclinicaltrial AT diegoagustinrodriguezchiaradia impactofhighflowoxygentherapyduringexerciseinidiopathicpulmonaryfibrosisapilotcrossoverclinicaltrial AT evabalcells impactofhighflowoxygentherapyduringexerciseinidiopathicpulmonaryfibrosisapilotcrossoverclinicaltrial
_version_	1718429141249818624

Impact of high-flow oxygen therapy during exercise in idiopathic pulmonary fibrosis: a pilot crossover clinical trial

Ejemplares similares