Coinfections with hepatitis B and C virus and syphilis among HIV-infected clients in Southern Ethiopia: a cross-sectional study

Techalew Shimelis,1 Yayheyirad Tassachew,1 Agete Tadewos,1 Mesfin Worku Hordofa,1 Anteneh Amsalu,2 Birkneh Tilahun Tadesse,3 Endale Tadesse1 1Department of Medical Laboratory Science, College of Medicine and Health Sciences Hawassa University, Hawassa, 2Department of Medical Microbiology, School of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shimelis T, Tassachew Y, Tadewos A, Hordofa MW, Amsalu A, Tadesse BT, Tadesse E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	HBV HCV HIV syphilis co-infection prevalence Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e9530ad105f04c0898529cc1f225f059
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e9530ad105f04c0898529cc1f225f059
record_format	dspace
spelling	oai:doaj.org-article:e9530ad105f04c0898529cc1f225f0592021-12-02T09:27:59ZCoinfections with hepatitis B and C virus and syphilis among HIV-infected clients in Southern Ethiopia: a cross-sectional study1179-1373https://doaj.org/article/e9530ad105f04c0898529cc1f225f0592017-12-01T00:00:00Zhttps://www.dovepress.com/coinfections-with-hepatitis-b-and-c-virus-and-syphilis-among-hiv-infec-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Techalew Shimelis,1 Yayheyirad Tassachew,1 Agete Tadewos,1 Mesfin Worku Hordofa,1 Anteneh Amsalu,2 Birkneh Tilahun Tadesse,3 Endale Tadesse1 1Department of Medical Laboratory Science, College of Medicine and Health Sciences Hawassa University, Hawassa, 2Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, University of Gondar, Gondar, 3Department of Pediatrics, School of Medicine, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia Introduction: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses of public health significance worldwide. Despite their severe clinical impact in HIV-infected patients, there is inadequate information regarding the epidemiology of hepatitis/HIV coinfections in Ethiopia. Thus, this study aimed to determine the prevalence of HBV and HCV infections among HIV-infected patients at a tertiary hospital in Southern Ethiopia. Methods: Stored sera, which were originally collected for the investigation of syphilis among HIV-infected clients, were analyzed in this study. Samples were tested for hepatitis B surface antigen (HBsAg) and antibody to hepatitis B core antigen using rapid diagnostic tests. Those samples that tested positive for HBsAg were further analyzed for hepatitis B e antigen. All sera were tested for antibody to HCV infection using rapid diagnostic test. Results: HBsAg was positive for 6.3% of the participants; of whom, 10% were positive for hepatitis B e antigen. The exposure rates to HBV (antibody to hepatitis B core antigen) and HCV (anti-HCV) infections were 22.4 and 3.1%, respectively. The rates of coinfections with HBV-syphilis, HCV-syphilis, and HBV-HCV were found to be 3.1, 0.6, and 1.3%, respectively. HBV exposure rate was significantly higher among participants in the age range 40–49 years (adjusted odds ratio [AOR], 1.98; 95% CI, 1.01–3.88) and those who had a CD4+ T cell count <200 cells/μL (AOR, 2.40; 95% CI, 1.13–5.10) and 200–349 cells/µL (AOR, 2.36; 95% CI, 1.28–4.35). Conclusion: The rates of HBV and HCV infections were found to be similar to other subpopulations in Ethiopia. Age and CD4+ T cell level influenced the rate of HBV exposure. As human immunodeficiency virus-hepatitis coinfections are clinically consequential in people living with human immunodeficiency virus/acquired immunodeficiency syndrome, the need to screen this population for HBV and HCV infections is critically important. Keywords: HBV, HCV, HIV, syphilis, coinfection, prevalenceShimelis TTassachew YTadewos AHordofa MWAmsalu ATadesse BTTadesse EDove Medical PressarticleHBVHCVHIVsyphilisco-infectionprevalenceImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 9, Pp 203-210 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	HBV HCV HIV syphilis co-infection prevalence Immunologic diseases. Allergy RC581-607
spellingShingle	HBV HCV HIV syphilis co-infection prevalence Immunologic diseases. Allergy RC581-607 Shimelis T Tassachew Y Tadewos A Hordofa MW Amsalu A Tadesse BT Tadesse E Coinfections with hepatitis B and C virus and syphilis among HIV-infected clients in Southern Ethiopia: a cross-sectional study
description	Techalew Shimelis,1 Yayheyirad Tassachew,1 Agete Tadewos,1 Mesfin Worku Hordofa,1 Anteneh Amsalu,2 Birkneh Tilahun Tadesse,3 Endale Tadesse1 1Department of Medical Laboratory Science, College of Medicine and Health Sciences Hawassa University, Hawassa, 2Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, University of Gondar, Gondar, 3Department of Pediatrics, School of Medicine, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia Introduction: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses of public health significance worldwide. Despite their severe clinical impact in HIV-infected patients, there is inadequate information regarding the epidemiology of hepatitis/HIV coinfections in Ethiopia. Thus, this study aimed to determine the prevalence of HBV and HCV infections among HIV-infected patients at a tertiary hospital in Southern Ethiopia. Methods: Stored sera, which were originally collected for the investigation of syphilis among HIV-infected clients, were analyzed in this study. Samples were tested for hepatitis B surface antigen (HBsAg) and antibody to hepatitis B core antigen using rapid diagnostic tests. Those samples that tested positive for HBsAg were further analyzed for hepatitis B e antigen. All sera were tested for antibody to HCV infection using rapid diagnostic test. Results: HBsAg was positive for 6.3% of the participants; of whom, 10% were positive for hepatitis B e antigen. The exposure rates to HBV (antibody to hepatitis B core antigen) and HCV (anti-HCV) infections were 22.4 and 3.1%, respectively. The rates of coinfections with HBV-syphilis, HCV-syphilis, and HBV-HCV were found to be 3.1, 0.6, and 1.3%, respectively. HBV exposure rate was significantly higher among participants in the age range 40–49 years (adjusted odds ratio [AOR], 1.98; 95% CI, 1.01–3.88) and those who had a CD4+ T cell count <200 cells/μL (AOR, 2.40; 95% CI, 1.13–5.10) and 200–349 cells/µL (AOR, 2.36; 95% CI, 1.28–4.35). Conclusion: The rates of HBV and HCV infections were found to be similar to other subpopulations in Ethiopia. Age and CD4+ T cell level influenced the rate of HBV exposure. As human immunodeficiency virus-hepatitis coinfections are clinically consequential in people living with human immunodeficiency virus/acquired immunodeficiency syndrome, the need to screen this population for HBV and HCV infections is critically important. Keywords: HBV, HCV, HIV, syphilis, coinfection, prevalence
format	article
author	Shimelis T Tassachew Y Tadewos A Hordofa MW Amsalu A Tadesse BT Tadesse E
author_facet	Shimelis T Tassachew Y Tadewos A Hordofa MW Amsalu A Tadesse BT Tadesse E
author_sort	Shimelis T
title	Coinfections with hepatitis B and C virus and syphilis among HIV-infected clients in Southern Ethiopia: a cross-sectional study
title_short	Coinfections with hepatitis B and C virus and syphilis among HIV-infected clients in Southern Ethiopia: a cross-sectional study
title_full	Coinfections with hepatitis B and C virus and syphilis among HIV-infected clients in Southern Ethiopia: a cross-sectional study
title_fullStr	Coinfections with hepatitis B and C virus and syphilis among HIV-infected clients in Southern Ethiopia: a cross-sectional study
title_full_unstemmed	Coinfections with hepatitis B and C virus and syphilis among HIV-infected clients in Southern Ethiopia: a cross-sectional study
title_sort	coinfections with hepatitis b and c virus and syphilis among hiv-infected clients in southern ethiopia: a cross-sectional study
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/e9530ad105f04c0898529cc1f225f059
work_keys_str_mv	AT shimelist coinfectionswithhepatitisbandcvirusandsyphilisamonghivinfectedclientsinsouthernethiopiaacrosssectionalstudy AT tassachewy coinfectionswithhepatitisbandcvirusandsyphilisamonghivinfectedclientsinsouthernethiopiaacrosssectionalstudy AT tadewosa coinfectionswithhepatitisbandcvirusandsyphilisamonghivinfectedclientsinsouthernethiopiaacrosssectionalstudy AT hordofamw coinfectionswithhepatitisbandcvirusandsyphilisamonghivinfectedclientsinsouthernethiopiaacrosssectionalstudy AT amsalua coinfectionswithhepatitisbandcvirusandsyphilisamonghivinfectedclientsinsouthernethiopiaacrosssectionalstudy AT tadessebt coinfectionswithhepatitisbandcvirusandsyphilisamonghivinfectedclientsinsouthernethiopiaacrosssectionalstudy AT tadessee coinfectionswithhepatitisbandcvirusandsyphilisamonghivinfectedclientsinsouthernethiopiaacrosssectionalstudy
_version_	1718398156316606464

Coinfections with hepatitis B and C virus and syphilis among HIV-infected clients in Southern Ethiopia: a cross-sectional study

Ejemplares similares