Immunometabolites Drive Bacterial Adaptation to the Airway

Pseudomonas aeruginosa and Staphylococcus aureus are both opportunistic pathogens that are frequently associated with chronic lung infections. While bacterial virulence determinants are critical in initiating infection, the metabolic flexibility of these bacteria promotes their persistence in the ai...

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Autores principales:	Kira L. Tomlinson, Alice S. Prince, Tania Wong Fok Lung
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	immunometabolism host-pathogen interaction bacterial persistence metabolic adaptation itaconate succinate Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e9539ca598bb4a55a3d9dac02bd5e3ae
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spelling	oai:doaj.org-article:e9539ca598bb4a55a3d9dac02bd5e3ae2021-12-01T02:31:59ZImmunometabolites Drive Bacterial Adaptation to the Airway1664-322410.3389/fimmu.2021.790574https://doaj.org/article/e9539ca598bb4a55a3d9dac02bd5e3ae2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.790574/fullhttps://doaj.org/toc/1664-3224Pseudomonas aeruginosa and Staphylococcus aureus are both opportunistic pathogens that are frequently associated with chronic lung infections. While bacterial virulence determinants are critical in initiating infection, the metabolic flexibility of these bacteria promotes their persistence in the airway. Upon infection, these pathogens induce host immunometabolic reprogramming, resulting in an airway milieu replete with immune-signaling metabolites. These metabolites are often toxic to the bacteria and create a steep selection pressure for the emergence of bacterial isolates adapted for long-term survival in the inflamed lung. In this review, we discuss the main differences in the host immunometabolic response to P. aeruginosa and S. aureus, as well as how these pathogens alter their own metabolism to adapt to airway metabolites and cause persistent lung infections.Kira L. TomlinsonAlice S. PrinceTania Wong Fok LungFrontiers Media S.A.articleimmunometabolismhost-pathogen interactionbacterial persistencemetabolic adaptationitaconatesuccinateImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunometabolism host-pathogen interaction bacterial persistence metabolic adaptation itaconate succinate Immunologic diseases. Allergy RC581-607
spellingShingle	immunometabolism host-pathogen interaction bacterial persistence metabolic adaptation itaconate succinate Immunologic diseases. Allergy RC581-607 Kira L. Tomlinson Alice S. Prince Tania Wong Fok Lung Immunometabolites Drive Bacterial Adaptation to the Airway
description	Pseudomonas aeruginosa and Staphylococcus aureus are both opportunistic pathogens that are frequently associated with chronic lung infections. While bacterial virulence determinants are critical in initiating infection, the metabolic flexibility of these bacteria promotes their persistence in the airway. Upon infection, these pathogens induce host immunometabolic reprogramming, resulting in an airway milieu replete with immune-signaling metabolites. These metabolites are often toxic to the bacteria and create a steep selection pressure for the emergence of bacterial isolates adapted for long-term survival in the inflamed lung. In this review, we discuss the main differences in the host immunometabolic response to P. aeruginosa and S. aureus, as well as how these pathogens alter their own metabolism to adapt to airway metabolites and cause persistent lung infections.
format	article
author	Kira L. Tomlinson Alice S. Prince Tania Wong Fok Lung
author_facet	Kira L. Tomlinson Alice S. Prince Tania Wong Fok Lung
author_sort	Kira L. Tomlinson
title	Immunometabolites Drive Bacterial Adaptation to the Airway
title_short	Immunometabolites Drive Bacterial Adaptation to the Airway
title_full	Immunometabolites Drive Bacterial Adaptation to the Airway
title_fullStr	Immunometabolites Drive Bacterial Adaptation to the Airway
title_full_unstemmed	Immunometabolites Drive Bacterial Adaptation to the Airway
title_sort	immunometabolites drive bacterial adaptation to the airway
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e9539ca598bb4a55a3d9dac02bd5e3ae
work_keys_str_mv	AT kiraltomlinson immunometabolitesdrivebacterialadaptationtotheairway AT alicesprince immunometabolitesdrivebacterialadaptationtotheairway AT taniawongfoklung immunometabolitesdrivebacterialadaptationtotheairway
_version_	1718405934700560384

Immunometabolites Drive Bacterial Adaptation to the Airway

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