Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors

Abstract To describe the long-term health outcomes of patients with COVID-19 and investigate the potential risk factors. Clinical data during hospitalization and at a mean (SD) day of 249 (15) days after discharge from 40 survivors with confirmed COVID-19 (including 25 severe cases) were collected a...

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Autores principales: Shengding Zhang, Wenxue Bai, Junqing Yue, Lu Qin, Cong Zhang, Shuyun Xu, Xiansheng Liu, Wang Ni, Min Xie
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e95424e8768a4dc5b0978ba72be72773
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spelling oai:doaj.org-article:e95424e8768a4dc5b0978ba72be727732021-12-02T15:39:40ZEight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors10.1038/s41598-021-93191-y2045-2322https://doaj.org/article/e95424e8768a4dc5b0978ba72be727732021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93191-yhttps://doaj.org/toc/2045-2322Abstract To describe the long-term health outcomes of patients with COVID-19 and investigate the potential risk factors. Clinical data during hospitalization and at a mean (SD) day of 249 (15) days after discharge from 40 survivors with confirmed COVID-19 (including 25 severe cases) were collected and analyzed retrospectively. At follow-up, severe cases had higher incidences of persistent symptoms, DLCO impairment, and higher abnormal CT score as compared with mild cases. CT score at follow-up was positively correlated with age, LDH level, cumulative days of oxygen treatment, total dosage of glucocorticoids used, and CT peak score during hospitalization. DLCO% at follow-up was negatively correlated with cumulative days of oxygen treatment during hospitalization. DLCO/VA% at follow-up was positively correlated with BMI, and TNF-α level. Among the three groups categorized as survivors with normal DLCO, abnormal DLCO but normal DLCO/VA, and abnormal DLCO and DLCO/VA, survivors with abnormal DLCO and DLCO/VA had the lowest serum IL-2R, IL-8, and TNF-α level, while the survivors with abnormal DLCO but normal DLCO/VA had the highest levels of inflammatory cytokines during hospitalization. Altogether, COVID-19 had a greater long-term impact on the lung physiology of severe cases. The long-term radiological abnormality maybe relate to old age and the severity of COVID-19. Either absent or excess of inflammation during COVID-19 course would lead to the impairment of pulmonary diffusion function.Shengding ZhangWenxue BaiJunqing YueLu QinCong ZhangShuyun XuXiansheng LiuWang NiMin XieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Shengding Zhang
Wenxue Bai
Junqing Yue
Lu Qin
Cong Zhang
Shuyun Xu
Xiansheng Liu
Wang Ni
Min Xie
Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors
description Abstract To describe the long-term health outcomes of patients with COVID-19 and investigate the potential risk factors. Clinical data during hospitalization and at a mean (SD) day of 249 (15) days after discharge from 40 survivors with confirmed COVID-19 (including 25 severe cases) were collected and analyzed retrospectively. At follow-up, severe cases had higher incidences of persistent symptoms, DLCO impairment, and higher abnormal CT score as compared with mild cases. CT score at follow-up was positively correlated with age, LDH level, cumulative days of oxygen treatment, total dosage of glucocorticoids used, and CT peak score during hospitalization. DLCO% at follow-up was negatively correlated with cumulative days of oxygen treatment during hospitalization. DLCO/VA% at follow-up was positively correlated with BMI, and TNF-α level. Among the three groups categorized as survivors with normal DLCO, abnormal DLCO but normal DLCO/VA, and abnormal DLCO and DLCO/VA, survivors with abnormal DLCO and DLCO/VA had the lowest serum IL-2R, IL-8, and TNF-α level, while the survivors with abnormal DLCO but normal DLCO/VA had the highest levels of inflammatory cytokines during hospitalization. Altogether, COVID-19 had a greater long-term impact on the lung physiology of severe cases. The long-term radiological abnormality maybe relate to old age and the severity of COVID-19. Either absent or excess of inflammation during COVID-19 course would lead to the impairment of pulmonary diffusion function.
format article
author Shengding Zhang
Wenxue Bai
Junqing Yue
Lu Qin
Cong Zhang
Shuyun Xu
Xiansheng Liu
Wang Ni
Min Xie
author_facet Shengding Zhang
Wenxue Bai
Junqing Yue
Lu Qin
Cong Zhang
Shuyun Xu
Xiansheng Liu
Wang Ni
Min Xie
author_sort Shengding Zhang
title Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors
title_short Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors
title_full Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors
title_fullStr Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors
title_full_unstemmed Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors
title_sort eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in covid-19 survivors
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e95424e8768a4dc5b0978ba72be72773
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