Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors
Abstract To describe the long-term health outcomes of patients with COVID-19 and investigate the potential risk factors. Clinical data during hospitalization and at a mean (SD) day of 249 (15) days after discharge from 40 survivors with confirmed COVID-19 (including 25 severe cases) were collected a...
Guardado en:
Autores principales: | , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/e95424e8768a4dc5b0978ba72be72773 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:e95424e8768a4dc5b0978ba72be72773 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:e95424e8768a4dc5b0978ba72be727732021-12-02T15:39:40ZEight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors10.1038/s41598-021-93191-y2045-2322https://doaj.org/article/e95424e8768a4dc5b0978ba72be727732021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93191-yhttps://doaj.org/toc/2045-2322Abstract To describe the long-term health outcomes of patients with COVID-19 and investigate the potential risk factors. Clinical data during hospitalization and at a mean (SD) day of 249 (15) days after discharge from 40 survivors with confirmed COVID-19 (including 25 severe cases) were collected and analyzed retrospectively. At follow-up, severe cases had higher incidences of persistent symptoms, DLCO impairment, and higher abnormal CT score as compared with mild cases. CT score at follow-up was positively correlated with age, LDH level, cumulative days of oxygen treatment, total dosage of glucocorticoids used, and CT peak score during hospitalization. DLCO% at follow-up was negatively correlated with cumulative days of oxygen treatment during hospitalization. DLCO/VA% at follow-up was positively correlated with BMI, and TNF-α level. Among the three groups categorized as survivors with normal DLCO, abnormal DLCO but normal DLCO/VA, and abnormal DLCO and DLCO/VA, survivors with abnormal DLCO and DLCO/VA had the lowest serum IL-2R, IL-8, and TNF-α level, while the survivors with abnormal DLCO but normal DLCO/VA had the highest levels of inflammatory cytokines during hospitalization. Altogether, COVID-19 had a greater long-term impact on the lung physiology of severe cases. The long-term radiological abnormality maybe relate to old age and the severity of COVID-19. Either absent or excess of inflammation during COVID-19 course would lead to the impairment of pulmonary diffusion function.Shengding ZhangWenxue BaiJunqing YueLu QinCong ZhangShuyun XuXiansheng LiuWang NiMin XieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Shengding Zhang Wenxue Bai Junqing Yue Lu Qin Cong Zhang Shuyun Xu Xiansheng Liu Wang Ni Min Xie Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors |
description |
Abstract To describe the long-term health outcomes of patients with COVID-19 and investigate the potential risk factors. Clinical data during hospitalization and at a mean (SD) day of 249 (15) days after discharge from 40 survivors with confirmed COVID-19 (including 25 severe cases) were collected and analyzed retrospectively. At follow-up, severe cases had higher incidences of persistent symptoms, DLCO impairment, and higher abnormal CT score as compared with mild cases. CT score at follow-up was positively correlated with age, LDH level, cumulative days of oxygen treatment, total dosage of glucocorticoids used, and CT peak score during hospitalization. DLCO% at follow-up was negatively correlated with cumulative days of oxygen treatment during hospitalization. DLCO/VA% at follow-up was positively correlated with BMI, and TNF-α level. Among the three groups categorized as survivors with normal DLCO, abnormal DLCO but normal DLCO/VA, and abnormal DLCO and DLCO/VA, survivors with abnormal DLCO and DLCO/VA had the lowest serum IL-2R, IL-8, and TNF-α level, while the survivors with abnormal DLCO but normal DLCO/VA had the highest levels of inflammatory cytokines during hospitalization. Altogether, COVID-19 had a greater long-term impact on the lung physiology of severe cases. The long-term radiological abnormality maybe relate to old age and the severity of COVID-19. Either absent or excess of inflammation during COVID-19 course would lead to the impairment of pulmonary diffusion function. |
format |
article |
author |
Shengding Zhang Wenxue Bai Junqing Yue Lu Qin Cong Zhang Shuyun Xu Xiansheng Liu Wang Ni Min Xie |
author_facet |
Shengding Zhang Wenxue Bai Junqing Yue Lu Qin Cong Zhang Shuyun Xu Xiansheng Liu Wang Ni Min Xie |
author_sort |
Shengding Zhang |
title |
Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors |
title_short |
Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors |
title_full |
Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors |
title_fullStr |
Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors |
title_full_unstemmed |
Eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in COVID-19 survivors |
title_sort |
eight months follow-up study on pulmonary function, lung radiographic, and related physiological characteristics in covid-19 survivors |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/e95424e8768a4dc5b0978ba72be72773 |
work_keys_str_mv |
AT shengdingzhang eightmonthsfollowupstudyonpulmonaryfunctionlungradiographicandrelatedphysiologicalcharacteristicsincovid19survivors AT wenxuebai eightmonthsfollowupstudyonpulmonaryfunctionlungradiographicandrelatedphysiologicalcharacteristicsincovid19survivors AT junqingyue eightmonthsfollowupstudyonpulmonaryfunctionlungradiographicandrelatedphysiologicalcharacteristicsincovid19survivors AT luqin eightmonthsfollowupstudyonpulmonaryfunctionlungradiographicandrelatedphysiologicalcharacteristicsincovid19survivors AT congzhang eightmonthsfollowupstudyonpulmonaryfunctionlungradiographicandrelatedphysiologicalcharacteristicsincovid19survivors AT shuyunxu eightmonthsfollowupstudyonpulmonaryfunctionlungradiographicandrelatedphysiologicalcharacteristicsincovid19survivors AT xianshengliu eightmonthsfollowupstudyonpulmonaryfunctionlungradiographicandrelatedphysiologicalcharacteristicsincovid19survivors AT wangni eightmonthsfollowupstudyonpulmonaryfunctionlungradiographicandrelatedphysiologicalcharacteristicsincovid19survivors AT minxie eightmonthsfollowupstudyonpulmonaryfunctionlungradiographicandrelatedphysiologicalcharacteristicsincovid19survivors |
_version_ |
1718385906479529984 |