TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling

The molecular mechanisms that regulate intestinal Clu+ revival stem cells (revSCs) and their niche to enable regeneration in response to injury are unclear. Here, the authors show that mice without the phospholipid transport protein, TNFAIP8, causes less revSCs to be induced following injury.

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Autores principales:	Jason R. Goldsmith, Nina Spitofsky, Ali Zamani, Ryan Hood, Amanda Boggs, Xinyuan Li, Mingyue Li, Elizabeth Reiner, Arshad Ayyaz, Zienab Etwebi, Ling Lu, Javier Rivera Guzman, Mayassa J. Bou-Dargham, Terry Cathoupolis, Hakon Hakonarson, Honghong Sun, Jeffrey L. Wrana, Michael V. Gonzalez, Youhai H. Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9560ffe66084f55bbdf91c1bdc498c6
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spelling	oai:doaj.org-article:e9560ffe66084f55bbdf91c1bdc498c62021-12-02T15:45:30ZTNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling10.1038/s41467-020-16379-22041-1723https://doaj.org/article/e9560ffe66084f55bbdf91c1bdc498c62020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16379-2https://doaj.org/toc/2041-1723The molecular mechanisms that regulate intestinal Clu+ revival stem cells (revSCs) and their niche to enable regeneration in response to injury are unclear. Here, the authors show that mice without the phospholipid transport protein, TNFAIP8, causes less revSCs to be induced following injury.Jason R. GoldsmithNina SpitofskyAli ZamaniRyan HoodAmanda BoggsXinyuan LiMingyue LiElizabeth ReinerArshad AyyazZienab EtwebiLing LuJavier Rivera GuzmanMayassa J. Bou-DarghamTerry CathoupolisHakon HakonarsonHonghong SunJeffrey L. WranaMichael V. GonzalezYouhai H. ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jason R. Goldsmith Nina Spitofsky Ali Zamani Ryan Hood Amanda Boggs Xinyuan Li Mingyue Li Elizabeth Reiner Arshad Ayyaz Zienab Etwebi Ling Lu Javier Rivera Guzman Mayassa J. Bou-Dargham Terry Cathoupolis Hakon Hakonarson Honghong Sun Jeffrey L. Wrana Michael V. Gonzalez Youhai H. Chen TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling
description	The molecular mechanisms that regulate intestinal Clu+ revival stem cells (revSCs) and their niche to enable regeneration in response to injury are unclear. Here, the authors show that mice without the phospholipid transport protein, TNFAIP8, causes less revSCs to be induced following injury.
format	article
author	Jason R. Goldsmith Nina Spitofsky Ali Zamani Ryan Hood Amanda Boggs Xinyuan Li Mingyue Li Elizabeth Reiner Arshad Ayyaz Zienab Etwebi Ling Lu Javier Rivera Guzman Mayassa J. Bou-Dargham Terry Cathoupolis Hakon Hakonarson Honghong Sun Jeffrey L. Wrana Michael V. Gonzalez Youhai H. Chen
author_facet	Jason R. Goldsmith Nina Spitofsky Ali Zamani Ryan Hood Amanda Boggs Xinyuan Li Mingyue Li Elizabeth Reiner Arshad Ayyaz Zienab Etwebi Ling Lu Javier Rivera Guzman Mayassa J. Bou-Dargham Terry Cathoupolis Hakon Hakonarson Honghong Sun Jeffrey L. Wrana Michael V. Gonzalez Youhai H. Chen
author_sort	Jason R. Goldsmith
title	TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling
title_short	TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling
title_full	TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling
title_fullStr	TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling
title_full_unstemmed	TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling
title_sort	tnfaip8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced akt signaling
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e9560ffe66084f55bbdf91c1bdc498c6
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TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling

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