Impact of viral features, host jumps and phylogeography on the rapid evolution of Aleutian mink disease virus (AMDV)

Abstract Aleutian mink disease virus (AMDV) is one the most relevant pathogens of domestic mink, where it can cause significant economic losses, and wild species, which are considered a threat to mink farms. Despite their relevance, many aspects of the origin, evolution, and geographic and host spre...

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Autores principales:	Giovanni Franzo, Matteo Legnardi, Laura Grassi, Giorgia Dotto, Michele Drigo, Mattia Cecchinato, Claudia Maria Tucciarone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e95724278c324a0994ffdbac5f3a494b
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spelling	oai:doaj.org-article:e95724278c324a0994ffdbac5f3a494b2021-12-02T16:28:00ZImpact of viral features, host jumps and phylogeography on the rapid evolution of Aleutian mink disease virus (AMDV)10.1038/s41598-021-96025-z2045-2322https://doaj.org/article/e95724278c324a0994ffdbac5f3a494b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96025-zhttps://doaj.org/toc/2045-2322Abstract Aleutian mink disease virus (AMDV) is one the most relevant pathogens of domestic mink, where it can cause significant economic losses, and wild species, which are considered a threat to mink farms. Despite their relevance, many aspects of the origin, evolution, and geographic and host spreading patterns of AMDV have never been investigated on a global scale using a comprehensive biostatistical approach. The present study, benefitting from a large dataset of sequences collected worldwide and several phylodynamic-based approaches, demonstrates the ancient origin of AMDV and its broad, unconstrained circulation from the initial intercontinental spread to the massive among-country circulation, especially within Europe, combined with local persistence and evolution. Clear expansion of the viral population size occurred over time until more effective control measures started to be applied. The role of frequent changes in epidemiological niches, including different hosts, in driving the high nucleotide and amino acid evolutionary rates was also explored by comparing the strengths of selective pressures acting on different populations. The obtained results suggest that the viral passage among locations and between wild and domesticated animals poses a double threat to farm profitability and animal welfare and health, which is particularly relevant for endangered species. Therefore, further efforts must be made to limit viral circulation and to refine our knowledge of factors enhancing AMDV spread, particularly at the wild-domestic interface.Giovanni FranzoMatteo LegnardiLaura GrassiGiorgia DottoMichele DrigoMattia CecchinatoClaudia Maria TucciaroneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giovanni Franzo Matteo Legnardi Laura Grassi Giorgia Dotto Michele Drigo Mattia Cecchinato Claudia Maria Tucciarone Impact of viral features, host jumps and phylogeography on the rapid evolution of Aleutian mink disease virus (AMDV)
description	Abstract Aleutian mink disease virus (AMDV) is one the most relevant pathogens of domestic mink, where it can cause significant economic losses, and wild species, which are considered a threat to mink farms. Despite their relevance, many aspects of the origin, evolution, and geographic and host spreading patterns of AMDV have never been investigated on a global scale using a comprehensive biostatistical approach. The present study, benefitting from a large dataset of sequences collected worldwide and several phylodynamic-based approaches, demonstrates the ancient origin of AMDV and its broad, unconstrained circulation from the initial intercontinental spread to the massive among-country circulation, especially within Europe, combined with local persistence and evolution. Clear expansion of the viral population size occurred over time until more effective control measures started to be applied. The role of frequent changes in epidemiological niches, including different hosts, in driving the high nucleotide and amino acid evolutionary rates was also explored by comparing the strengths of selective pressures acting on different populations. The obtained results suggest that the viral passage among locations and between wild and domesticated animals poses a double threat to farm profitability and animal welfare and health, which is particularly relevant for endangered species. Therefore, further efforts must be made to limit viral circulation and to refine our knowledge of factors enhancing AMDV spread, particularly at the wild-domestic interface.
format	article
author	Giovanni Franzo Matteo Legnardi Laura Grassi Giorgia Dotto Michele Drigo Mattia Cecchinato Claudia Maria Tucciarone
author_facet	Giovanni Franzo Matteo Legnardi Laura Grassi Giorgia Dotto Michele Drigo Mattia Cecchinato Claudia Maria Tucciarone
author_sort	Giovanni Franzo
title	Impact of viral features, host jumps and phylogeography on the rapid evolution of Aleutian mink disease virus (AMDV)
title_short	Impact of viral features, host jumps and phylogeography on the rapid evolution of Aleutian mink disease virus (AMDV)
title_full	Impact of viral features, host jumps and phylogeography on the rapid evolution of Aleutian mink disease virus (AMDV)
title_fullStr	Impact of viral features, host jumps and phylogeography on the rapid evolution of Aleutian mink disease virus (AMDV)
title_full_unstemmed	Impact of viral features, host jumps and phylogeography on the rapid evolution of Aleutian mink disease virus (AMDV)
title_sort	impact of viral features, host jumps and phylogeography on the rapid evolution of aleutian mink disease virus (amdv)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e95724278c324a0994ffdbac5f3a494b
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Impact of viral features, host jumps and phylogeography on the rapid evolution of Aleutian mink disease virus (AMDV)

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