Biological and physical approaches on the role of piplartine (piperlongumine) in cancer

Abstract Chronic inflammation provides a favorable microenvironment for tumorigenesis, which opens opportunities for targeting cancer development and progression. Piplartine (PL) is a biologically active alkaloid from long peppers that exhibits anti-inflammatory and antitumor activity. In the presen...

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Autores principales:	Tiago Henrique, Caroline de F. Zanon, Ana P. Girol, Ana Carolina Buzzo Stefanini, Nayara S. de A. Contessoto, Nelson J. F. da Silveira, Daniel P. Bezerra, Edilberto R. Silveira, José M. Barbosa-Filho, Marinonio L. Cornélio, Sonia M. Oliani, Eloiza H. Tajara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e95b2021fb1e40a0a8564a1695d8be4f
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spelling	oai:doaj.org-article:e95b2021fb1e40a0a8564a1695d8be4f2021-12-02T13:58:14ZBiological and physical approaches on the role of piplartine (piperlongumine) in cancer10.1038/s41598-020-78220-62045-2322https://doaj.org/article/e95b2021fb1e40a0a8564a1695d8be4f2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78220-6https://doaj.org/toc/2045-2322Abstract Chronic inflammation provides a favorable microenvironment for tumorigenesis, which opens opportunities for targeting cancer development and progression. Piplartine (PL) is a biologically active alkaloid from long peppers that exhibits anti-inflammatory and antitumor activity. In the present study, we investigated the physical and chemical interactions of PL with anti-inflammatory compounds and their effects on cell proliferation and migration and on the gene expression of inflammatory mediators. Molecular docking data and physicochemical analysis suggested that PL shows potential interactions with a peptide of annexin A1 (ANXA1), an endogenous anti-inflammatory mediator with therapeutic potential in cancer. Treatment of neoplastic cells with PL alone or with annexin A1 mimic peptide reduced cell proliferation and viability and modulated the expression of MCP-1 chemokine, IL-8 cytokine and genes involved in inflammatory processes. The results also suggested an inhibitory effect of PL on tubulin expression. In addition, PL apparently had no influence on cell migration and invasion at the concentration tested. Considering the role of inflammation in the context of promoting tumor initiation, the present study shows the potential of piplartine as a therapeutic immunomodulator for cancer prevention and progression.Tiago HenriqueCaroline de F. ZanonAna P. GirolAna Carolina Buzzo StefaniniNayara S. de A. ContessotoNelson J. F. da SilveiraDaniel P. BezerraEdilberto R. SilveiraJosé M. Barbosa-FilhoMarinonio L. CornélioSonia M. OlianiEloiza H. TajaraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tiago Henrique Caroline de F. Zanon Ana P. Girol Ana Carolina Buzzo Stefanini Nayara S. de A. Contessoto Nelson J. F. da Silveira Daniel P. Bezerra Edilberto R. Silveira José M. Barbosa-Filho Marinonio L. Cornélio Sonia M. Oliani Eloiza H. Tajara Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
description	Abstract Chronic inflammation provides a favorable microenvironment for tumorigenesis, which opens opportunities for targeting cancer development and progression. Piplartine (PL) is a biologically active alkaloid from long peppers that exhibits anti-inflammatory and antitumor activity. In the present study, we investigated the physical and chemical interactions of PL with anti-inflammatory compounds and their effects on cell proliferation and migration and on the gene expression of inflammatory mediators. Molecular docking data and physicochemical analysis suggested that PL shows potential interactions with a peptide of annexin A1 (ANXA1), an endogenous anti-inflammatory mediator with therapeutic potential in cancer. Treatment of neoplastic cells with PL alone or with annexin A1 mimic peptide reduced cell proliferation and viability and modulated the expression of MCP-1 chemokine, IL-8 cytokine and genes involved in inflammatory processes. The results also suggested an inhibitory effect of PL on tubulin expression. In addition, PL apparently had no influence on cell migration and invasion at the concentration tested. Considering the role of inflammation in the context of promoting tumor initiation, the present study shows the potential of piplartine as a therapeutic immunomodulator for cancer prevention and progression.
format	article
author	Tiago Henrique Caroline de F. Zanon Ana P. Girol Ana Carolina Buzzo Stefanini Nayara S. de A. Contessoto Nelson J. F. da Silveira Daniel P. Bezerra Edilberto R. Silveira José M. Barbosa-Filho Marinonio L. Cornélio Sonia M. Oliani Eloiza H. Tajara
author_facet	Tiago Henrique Caroline de F. Zanon Ana P. Girol Ana Carolina Buzzo Stefanini Nayara S. de A. Contessoto Nelson J. F. da Silveira Daniel P. Bezerra Edilberto R. Silveira José M. Barbosa-Filho Marinonio L. Cornélio Sonia M. Oliani Eloiza H. Tajara
author_sort	Tiago Henrique
title	Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
title_short	Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
title_full	Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
title_fullStr	Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
title_full_unstemmed	Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
title_sort	biological and physical approaches on the role of piplartine (piperlongumine) in cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e95b2021fb1e40a0a8564a1695d8be4f
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Biological and physical approaches on the role of piplartine (piperlongumine) in cancer

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