MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes
Antidepressant drugs are the most common treatment for depressive episodes but only a fraction of patients experience adequate response. Here the authors find dysregulation of miRNAs in peripheral blood samples from depressed patients after antidepressant treatment, and show that the miRNAs are regu...
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Nature Portfolio
2017
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oai:doaj.org-article:e95c158a05b749e2a3450c3b601e85932021-12-02T14:40:21ZMicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes10.1038/ncomms154972041-1723https://doaj.org/article/e95c158a05b749e2a3450c3b601e85932017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15497https://doaj.org/toc/2041-1723Antidepressant drugs are the most common treatment for depressive episodes but only a fraction of patients experience adequate response. Here the authors find dysregulation of miRNAs in peripheral blood samples from depressed patients after antidepressant treatment, and show that the miRNAs are regulators of psychiatrically relevant signalling pathways.Juan Pablo LopezLaura M. FioriCristiana CruceanuRixing LinBenoit LabonteHannah M. CatesElizabeth A. HellerVincent VialouStacy M. KuChristophe GeraldMing-Hu HanJane FosterBenicio N. FreyClaudio N. SoaresDaniel J. MüllerFaranak FarzanFrancesco LeriGlenda M. MacQueenHarriet FeilotterKathrin TyryshkinKenneth R. EvansPeter GiacobbePierre BlierRaymond W. LamRoumen MilevSagar V. ParikhSusan RotzingerSteven C. StrotherCathryn M. LewisKatherine J. AitchisonGayle M. WittenbergNaguib MechawarEric J. NestlerRudolf UherSidney H. KennedyGustavo TureckiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Juan Pablo Lopez Laura M. Fiori Cristiana Cruceanu Rixing Lin Benoit Labonte Hannah M. Cates Elizabeth A. Heller Vincent Vialou Stacy M. Ku Christophe Gerald Ming-Hu Han Jane Foster Benicio N. Frey Claudio N. Soares Daniel J. Müller Faranak Farzan Francesco Leri Glenda M. MacQueen Harriet Feilotter Kathrin Tyryshkin Kenneth R. Evans Peter Giacobbe Pierre Blier Raymond W. Lam Roumen Milev Sagar V. Parikh Susan Rotzinger Steven C. Strother Cathryn M. Lewis Katherine J. Aitchison Gayle M. Wittenberg Naguib Mechawar Eric J. Nestler Rudolf Uher Sidney H. Kennedy Gustavo Turecki MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes |
| description |
Antidepressant drugs are the most common treatment for depressive episodes but only a fraction of patients experience adequate response. Here the authors find dysregulation of miRNAs in peripheral blood samples from depressed patients after antidepressant treatment, and show that the miRNAs are regulators of psychiatrically relevant signalling pathways. |
| format |
article |
| author |
Juan Pablo Lopez Laura M. Fiori Cristiana Cruceanu Rixing Lin Benoit Labonte Hannah M. Cates Elizabeth A. Heller Vincent Vialou Stacy M. Ku Christophe Gerald Ming-Hu Han Jane Foster Benicio N. Frey Claudio N. Soares Daniel J. Müller Faranak Farzan Francesco Leri Glenda M. MacQueen Harriet Feilotter Kathrin Tyryshkin Kenneth R. Evans Peter Giacobbe Pierre Blier Raymond W. Lam Roumen Milev Sagar V. Parikh Susan Rotzinger Steven C. Strother Cathryn M. Lewis Katherine J. Aitchison Gayle M. Wittenberg Naguib Mechawar Eric J. Nestler Rudolf Uher Sidney H. Kennedy Gustavo Turecki |
| author_facet |
Juan Pablo Lopez Laura M. Fiori Cristiana Cruceanu Rixing Lin Benoit Labonte Hannah M. Cates Elizabeth A. Heller Vincent Vialou Stacy M. Ku Christophe Gerald Ming-Hu Han Jane Foster Benicio N. Frey Claudio N. Soares Daniel J. Müller Faranak Farzan Francesco Leri Glenda M. MacQueen Harriet Feilotter Kathrin Tyryshkin Kenneth R. Evans Peter Giacobbe Pierre Blier Raymond W. Lam Roumen Milev Sagar V. Parikh Susan Rotzinger Steven C. Strother Cathryn M. Lewis Katherine J. Aitchison Gayle M. Wittenberg Naguib Mechawar Eric J. Nestler Rudolf Uher Sidney H. Kennedy Gustavo Turecki |
| author_sort |
Juan Pablo Lopez |
| title |
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes |
| title_short |
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes |
| title_full |
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes |
| title_fullStr |
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes |
| title_full_unstemmed |
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes |
| title_sort |
micrornas 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate mapk/wnt-system genes |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/e95c158a05b749e2a3450c3b601e8593 |
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