Cardiac Surgery Associated AKI Prevention Strategies and Medical Treatment for CSA-AKI

Acute kidney injury (AKI) is common after cardiac surgery. To date, there are no specific pharmacological therapies. In this review, we summarise the existing evidence for prevention and management of cardiac surgery-associated AKI and outline areas for future research. Preoperatively, angiotensin-c...

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Autores principales: Marlies Ostermann, Gudrun Kunst, Eleanor Baker, Kittisak Weerapolchai, Nuttha Lumlertgul
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/e95cd90984504f1ea79016eac84aade0
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spelling oai:doaj.org-article:e95cd90984504f1ea79016eac84aade02021-11-25T18:01:24ZCardiac Surgery Associated AKI Prevention Strategies and Medical Treatment for CSA-AKI10.3390/jcm102252852077-0383https://doaj.org/article/e95cd90984504f1ea79016eac84aade02021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5285https://doaj.org/toc/2077-0383Acute kidney injury (AKI) is common after cardiac surgery. To date, there are no specific pharmacological therapies. In this review, we summarise the existing evidence for prevention and management of cardiac surgery-associated AKI and outline areas for future research. Preoperatively, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers should be withheld and nephrotoxins should be avoided to reduce the risk. Intraoperative strategies include goal-directed therapy with individualised blood pressure management and administration of balanced fluids, the use of circuits with biocompatible coatings, application of minimally invasive extracorporeal circulation, and lung protective ventilation. Postoperative management should be in accordance with current KDIGO AKI recommendations.Marlies OstermannGudrun KunstEleanor BakerKittisak WeerapolchaiNuttha LumlertgulMDPI AGarticleacute kidney injury (AKI)cardiac surgerycardiac surgery associated AKIpreventionmanagementcardiovascularMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5285, p 5285 (2021)
institution DOAJ
collection DOAJ
language EN
topic acute kidney injury (AKI)
cardiac surgery
cardiac surgery associated AKI
prevention
management
cardiovascular
Medicine
R
spellingShingle acute kidney injury (AKI)
cardiac surgery
cardiac surgery associated AKI
prevention
management
cardiovascular
Medicine
R
Marlies Ostermann
Gudrun Kunst
Eleanor Baker
Kittisak Weerapolchai
Nuttha Lumlertgul
Cardiac Surgery Associated AKI Prevention Strategies and Medical Treatment for CSA-AKI
description Acute kidney injury (AKI) is common after cardiac surgery. To date, there are no specific pharmacological therapies. In this review, we summarise the existing evidence for prevention and management of cardiac surgery-associated AKI and outline areas for future research. Preoperatively, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers should be withheld and nephrotoxins should be avoided to reduce the risk. Intraoperative strategies include goal-directed therapy with individualised blood pressure management and administration of balanced fluids, the use of circuits with biocompatible coatings, application of minimally invasive extracorporeal circulation, and lung protective ventilation. Postoperative management should be in accordance with current KDIGO AKI recommendations.
format article
author Marlies Ostermann
Gudrun Kunst
Eleanor Baker
Kittisak Weerapolchai
Nuttha Lumlertgul
author_facet Marlies Ostermann
Gudrun Kunst
Eleanor Baker
Kittisak Weerapolchai
Nuttha Lumlertgul
author_sort Marlies Ostermann
title Cardiac Surgery Associated AKI Prevention Strategies and Medical Treatment for CSA-AKI
title_short Cardiac Surgery Associated AKI Prevention Strategies and Medical Treatment for CSA-AKI
title_full Cardiac Surgery Associated AKI Prevention Strategies and Medical Treatment for CSA-AKI
title_fullStr Cardiac Surgery Associated AKI Prevention Strategies and Medical Treatment for CSA-AKI
title_full_unstemmed Cardiac Surgery Associated AKI Prevention Strategies and Medical Treatment for CSA-AKI
title_sort cardiac surgery associated aki prevention strategies and medical treatment for csa-aki
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/e95cd90984504f1ea79016eac84aade0
work_keys_str_mv AT marliesostermann cardiacsurgeryassociatedakipreventionstrategiesandmedicaltreatmentforcsaaki
AT gudrunkunst cardiacsurgeryassociatedakipreventionstrategiesandmedicaltreatmentforcsaaki
AT eleanorbaker cardiacsurgeryassociatedakipreventionstrategiesandmedicaltreatmentforcsaaki
AT kittisakweerapolchai cardiacsurgeryassociatedakipreventionstrategiesandmedicaltreatmentforcsaaki
AT nutthalumlertgul cardiacsurgeryassociatedakipreventionstrategiesandmedicaltreatmentforcsaaki
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