Radiotherapy in the Treatment of Subcutaneous Melanoma

Malignant melanoma frequently develops cutaneous and/or subcutaneous metastases during the course of the disease. These may present as non-nodal locoregional metastases (microsatellite, satellite, or in-transit) included in stage III or as distant metastases in stage IV. Their presentation is hetero...

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Autores principales:	Valentina Borzillo, Paolo Muto
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	subcutaneous melanoma radiotherapy hyperthermia BNCT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e95f2e14898f4b25905d87355c8e6e34
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spelling	oai:doaj.org-article:e95f2e14898f4b25905d87355c8e6e342021-11-25T17:04:52ZRadiotherapy in the Treatment of Subcutaneous Melanoma10.3390/cancers132258592072-6694https://doaj.org/article/e95f2e14898f4b25905d87355c8e6e342021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5859https://doaj.org/toc/2072-6694Malignant melanoma frequently develops cutaneous and/or subcutaneous metastases during the course of the disease. These may present as non-nodal locoregional metastases (microsatellite, satellite, or in-transit) included in stage III or as distant metastases in stage IV. Their presentation is heterogeneous and associated with significant morbidity resulting from both disease-related functional damage and treatment side effects. The standard treatment is surgical excision, whereas local therapies or systemic therapies have a role when surgery is not indicated. Radiotherapy can be used in the local management of ITM, subcutaneous relapses, or distant metastases to provide symptom relief and prolong regional disease control. To increase the local response without increasing toxicity, the addition of hyperthermia and intralesional therapies to radiotherapy appear to be very promising. Boron neutron capture therapy, based on nuclear neutron capture and boron isotope fission reaction, could be an alternative to standard treatments, but its use in clinical practice is still limited. The potential benefit of combining radiotherapy with targeted therapies and immunotherapy has yet to be explored in this lesion setting. This review explores the role of radiotherapy in the treatment of cutaneous and subcutaneous lesions, its impact on outcomes, and its association with other treatment modalities.Valentina BorzilloPaolo MutoMDPI AGarticlesubcutaneous melanomaradiotherapyhyperthermiaBNCTNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5859, p 5859 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	subcutaneous melanoma radiotherapy hyperthermia BNCT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	subcutaneous melanoma radiotherapy hyperthermia BNCT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Valentina Borzillo Paolo Muto Radiotherapy in the Treatment of Subcutaneous Melanoma
description	Malignant melanoma frequently develops cutaneous and/or subcutaneous metastases during the course of the disease. These may present as non-nodal locoregional metastases (microsatellite, satellite, or in-transit) included in stage III or as distant metastases in stage IV. Their presentation is heterogeneous and associated with significant morbidity resulting from both disease-related functional damage and treatment side effects. The standard treatment is surgical excision, whereas local therapies or systemic therapies have a role when surgery is not indicated. Radiotherapy can be used in the local management of ITM, subcutaneous relapses, or distant metastases to provide symptom relief and prolong regional disease control. To increase the local response without increasing toxicity, the addition of hyperthermia and intralesional therapies to radiotherapy appear to be very promising. Boron neutron capture therapy, based on nuclear neutron capture and boron isotope fission reaction, could be an alternative to standard treatments, but its use in clinical practice is still limited. The potential benefit of combining radiotherapy with targeted therapies and immunotherapy has yet to be explored in this lesion setting. This review explores the role of radiotherapy in the treatment of cutaneous and subcutaneous lesions, its impact on outcomes, and its association with other treatment modalities.
format	article
author	Valentina Borzillo Paolo Muto
author_facet	Valentina Borzillo Paolo Muto
author_sort	Valentina Borzillo
title	Radiotherapy in the Treatment of Subcutaneous Melanoma
title_short	Radiotherapy in the Treatment of Subcutaneous Melanoma
title_full	Radiotherapy in the Treatment of Subcutaneous Melanoma
title_fullStr	Radiotherapy in the Treatment of Subcutaneous Melanoma
title_full_unstemmed	Radiotherapy in the Treatment of Subcutaneous Melanoma
title_sort	radiotherapy in the treatment of subcutaneous melanoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e95f2e14898f4b25905d87355c8e6e34
work_keys_str_mv	AT valentinaborzillo radiotherapyinthetreatmentofsubcutaneousmelanoma AT paolomuto radiotherapyinthetreatmentofsubcutaneousmelanoma
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Radiotherapy in the Treatment of Subcutaneous Melanoma

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