Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea

Abstract Continuous positive airway pressure (CPAP) is simple and effective treatment for obstructive sleep apnea (OSA) patients. However, the CPAP prediction equation in each country is different. This study aimed to predict CPAP in Thai patients with OSA. A retrospective study was conducted in Tha...

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Autores principales:	Narongkorn Saiphoklang, Kanyada Leelasittikul, Apiwat Pugongchai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9639f6e6f9c40da80a4be15bebc7a08
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spelling	oai:doaj.org-article:e9639f6e6f9c40da80a4be15bebc7a082021-12-02T18:34:13ZPrediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea10.1038/s41598-021-93554-52045-2322https://doaj.org/article/e9639f6e6f9c40da80a4be15bebc7a082021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93554-5https://doaj.org/toc/2045-2322Abstract Continuous positive airway pressure (CPAP) is simple and effective treatment for obstructive sleep apnea (OSA) patients. However, the CPAP prediction equation in each country is different. This study aimed to predict CPAP in Thai patients with OSA. A retrospective study was conducted in Thai patients, who OSA was confirmed by polysomnography and CPAP titration from January 2015 to December 2018. Demographics, body mass index (BMI), neck circumference (NC), Epworth sleepiness scale, apnea–hypopnea index (AHI), respiratory disturbance index (RDI), mean and lowest pulse oxygen saturation (SpO2), and optimal pressure were recorded. A total of 180 subjects were included: 72.8% men, age 48.7 ± 12.7 years, BMI 31.0 ± 6.3 kg/m2, NC 40.7 ± 4.1 cm, AHI 42.5 ± 33.0 per hour, RDI 47.1 ± 32.8 per hour, and lowest SpO2 77.1 ± 11.0%. Multiple linear regression analysis identified NC, BMI, RDI, and lowest SpO2. A final CPAP predictive equation was: optimal CPAP (cmH2O) = 4.614 + (0.173 × NC) + (0.067 × BMI) + (0.030 × RDI) − (0.076 × lowest SpO2). This model accounted for 50.0% of the variance in the optimal pressure (R2 = 0.50). In conclusion, a CPAP prediction equation can be used to explain a moderate proportion of the titrated CPAP in Thai patients with OSA. However, the CPAP predictive equation in each country may be different due to differences of ethnicity and physiology. Trial registration: TCTR20200108003.Narongkorn SaiphoklangKanyada LeelasittikulApiwat PugongchaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Narongkorn Saiphoklang Kanyada Leelasittikul Apiwat Pugongchai Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea
description	Abstract Continuous positive airway pressure (CPAP) is simple and effective treatment for obstructive sleep apnea (OSA) patients. However, the CPAP prediction equation in each country is different. This study aimed to predict CPAP in Thai patients with OSA. A retrospective study was conducted in Thai patients, who OSA was confirmed by polysomnography and CPAP titration from January 2015 to December 2018. Demographics, body mass index (BMI), neck circumference (NC), Epworth sleepiness scale, apnea–hypopnea index (AHI), respiratory disturbance index (RDI), mean and lowest pulse oxygen saturation (SpO2), and optimal pressure were recorded. A total of 180 subjects were included: 72.8% men, age 48.7 ± 12.7 years, BMI 31.0 ± 6.3 kg/m2, NC 40.7 ± 4.1 cm, AHI 42.5 ± 33.0 per hour, RDI 47.1 ± 32.8 per hour, and lowest SpO2 77.1 ± 11.0%. Multiple linear regression analysis identified NC, BMI, RDI, and lowest SpO2. A final CPAP predictive equation was: optimal CPAP (cmH2O) = 4.614 + (0.173 × NC) + (0.067 × BMI) + (0.030 × RDI) − (0.076 × lowest SpO2). This model accounted for 50.0% of the variance in the optimal pressure (R2 = 0.50). In conclusion, a CPAP prediction equation can be used to explain a moderate proportion of the titrated CPAP in Thai patients with OSA. However, the CPAP predictive equation in each country may be different due to differences of ethnicity and physiology. Trial registration: TCTR20200108003.
format	article
author	Narongkorn Saiphoklang Kanyada Leelasittikul Apiwat Pugongchai
author_facet	Narongkorn Saiphoklang Kanyada Leelasittikul Apiwat Pugongchai
author_sort	Narongkorn Saiphoklang
title	Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea
title_short	Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea
title_full	Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea
title_fullStr	Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea
title_full_unstemmed	Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea
title_sort	prediction of optimal continuous positive airway pressure in thai patients with obstructive sleep apnea
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e9639f6e6f9c40da80a4be15bebc7a08
work_keys_str_mv	AT narongkornsaiphoklang predictionofoptimalcontinuouspositiveairwaypressureinthaipatientswithobstructivesleepapnea AT kanyadaleelasittikul predictionofoptimalcontinuouspositiveairwaypressureinthaipatientswithobstructivesleepapnea AT apiwatpugongchai predictionofoptimalcontinuouspositiveairwaypressureinthaipatientswithobstructivesleepapnea
_version_	1718377894133104640

Prediction of optimal continuous positive airway pressure in Thai patients with obstructive sleep apnea

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