Adverse drug reactions of anti-infective drugs for systemic use in Morocco: Pharmaco-Epidemiological study 2008-2016

Analyzing the spontaneous reports of adverse drug reactions (ADRs) of anti-infective drugs for systemic use is an essential pillar in creating valuable database in pharmacovigilance.Therefore, the main of this study is to describe the epidemiological and clinical properties, as well as, the frequenc...

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Autores principales:	Kharbouch Donia, Sefiani Houda, Nabih Zineb, Coulibaly Sanou Khô, Diallo Tidiane, Soulaymani Abdelmajid, Mokhtari Abdelrhani, Bencheikh Rachida Soulaymani
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	adverse drug reactions pharmacovigilance anti-infective drugs for systemic use antibiotics morocco mappc Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/e9644da6261942e89eddd6dcdf234406
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spelling	oai:doaj.org-article:e9644da6261942e89eddd6dcdf2344062021-11-12T11:44:08ZAdverse drug reactions of anti-infective drugs for systemic use in Morocco: Pharmaco-Epidemiological study 2008-20162267-124210.1051/e3sconf/202131901048https://doaj.org/article/e9644da6261942e89eddd6dcdf2344062021-01-01T00:00:00Zhttps://www.e3s-conferences.org/articles/e3sconf/pdf/2021/95/e3sconf_vigisan_01048.pdfhttps://doaj.org/toc/2267-1242Analyzing the spontaneous reports of adverse drug reactions (ADRs) of anti-infective drugs for systemic use is an essential pillar in creating valuable database in pharmacovigilance.Therefore, the main of this study is to describe the epidemiological and clinical properties, as well as, the frequency and profile of ADRs generated by anti-infective treatment, declared at the Moroccan Anti-Poison and Pharmacovigilance Center (MAPPC).A retrospective descriptive study was implemented from the notifications of ADRs generated between 2008 and 2016 and recorded on VIGIBASE. Over the research period, 1161 cases of ADRs reports were declared. The average age was 37.4 years ± 19.52, it’s been noticed that the adults were the most affected in 81.89% of the total cases, with the sex ratio (Female / Male) being 1.34. Antimycobacterials and antibacterials for systemic use were responsible for 68% and 28.3% of the adverse reactions, respectively. 29.76% of the cases showcased skin and subcutaneous tissue disorders and 23.23% of the cases displayed hepatobiliary and pancreatic system disorders. Serious cases represented 30% of all noted cases, including 2 fatalities. In the interest of preventing the risk of adverse reactions originating from the taking anti-infective drugs for systemic use, reporting to the ADRs to the pharmacovigilance system should be highly encouraged.Kharbouch DoniaSefiani HoudaNabih ZinebCoulibaly Sanou KhôDiallo TidianeSoulaymani AbdelmajidMokhtari AbdelrhaniBencheikh Rachida SoulaymaniEDP Sciencesarticleadverse drug reactionspharmacovigilanceanti-infective drugs for systemic useantibioticsmoroccomappcEnvironmental sciencesGE1-350ENFRE3S Web of Conferences, Vol 319, p 01048 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	adverse drug reactions pharmacovigilance anti-infective drugs for systemic use antibiotics morocco mappc Environmental sciences GE1-350
spellingShingle	adverse drug reactions pharmacovigilance anti-infective drugs for systemic use antibiotics morocco mappc Environmental sciences GE1-350 Kharbouch Donia Sefiani Houda Nabih Zineb Coulibaly Sanou Khô Diallo Tidiane Soulaymani Abdelmajid Mokhtari Abdelrhani Bencheikh Rachida Soulaymani Adverse drug reactions of anti-infective drugs for systemic use in Morocco: Pharmaco-Epidemiological study 2008-2016
description	Analyzing the spontaneous reports of adverse drug reactions (ADRs) of anti-infective drugs for systemic use is an essential pillar in creating valuable database in pharmacovigilance.Therefore, the main of this study is to describe the epidemiological and clinical properties, as well as, the frequency and profile of ADRs generated by anti-infective treatment, declared at the Moroccan Anti-Poison and Pharmacovigilance Center (MAPPC).A retrospective descriptive study was implemented from the notifications of ADRs generated between 2008 and 2016 and recorded on VIGIBASE. Over the research period, 1161 cases of ADRs reports were declared. The average age was 37.4 years ± 19.52, it’s been noticed that the adults were the most affected in 81.89% of the total cases, with the sex ratio (Female / Male) being 1.34. Antimycobacterials and antibacterials for systemic use were responsible for 68% and 28.3% of the adverse reactions, respectively. 29.76% of the cases showcased skin and subcutaneous tissue disorders and 23.23% of the cases displayed hepatobiliary and pancreatic system disorders. Serious cases represented 30% of all noted cases, including 2 fatalities. In the interest of preventing the risk of adverse reactions originating from the taking anti-infective drugs for systemic use, reporting to the ADRs to the pharmacovigilance system should be highly encouraged.
format	article
author	Kharbouch Donia Sefiani Houda Nabih Zineb Coulibaly Sanou Khô Diallo Tidiane Soulaymani Abdelmajid Mokhtari Abdelrhani Bencheikh Rachida Soulaymani
author_facet	Kharbouch Donia Sefiani Houda Nabih Zineb Coulibaly Sanou Khô Diallo Tidiane Soulaymani Abdelmajid Mokhtari Abdelrhani Bencheikh Rachida Soulaymani
author_sort	Kharbouch Donia
title	Adverse drug reactions of anti-infective drugs for systemic use in Morocco: Pharmaco-Epidemiological study 2008-2016
title_short	Adverse drug reactions of anti-infective drugs for systemic use in Morocco: Pharmaco-Epidemiological study 2008-2016
title_full	Adverse drug reactions of anti-infective drugs for systemic use in Morocco: Pharmaco-Epidemiological study 2008-2016
title_fullStr	Adverse drug reactions of anti-infective drugs for systemic use in Morocco: Pharmaco-Epidemiological study 2008-2016
title_full_unstemmed	Adverse drug reactions of anti-infective drugs for systemic use in Morocco: Pharmaco-Epidemiological study 2008-2016
title_sort	adverse drug reactions of anti-infective drugs for systemic use in morocco: pharmaco-epidemiological study 2008-2016
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/e9644da6261942e89eddd6dcdf234406
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Adverse drug reactions of anti-infective drugs for systemic use in Morocco: Pharmaco-Epidemiological study 2008-2016

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