STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.

<h4>Background</h4>A recent genome-wide association study identified STK39as a candidate gene for blood pressure (BP) in Europeans. Subsequently, several studies have attempted to replicate the association across different ethnic populations. However, the results have been inconsistent.&...

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Autores principales:	Bo Xi, Man Chen, Giriraj R Chandak, Yue Shen, Li Yan, Juan He, Si-Hua Mou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9650553bd624fd881cd7118d794ea4a
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spelling	oai:doaj.org-article:e9650553bd624fd881cd7118d794ea4a2021-11-18T07:53:05ZSTK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.1932-620310.1371/journal.pone.0059584https://doaj.org/article/e9650553bd624fd881cd7118d794ea4a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23527223/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>A recent genome-wide association study identified STK39as a candidate gene for blood pressure (BP) in Europeans. Subsequently, several studies have attempted to replicate the association across different ethnic populations. However, the results have been inconsistent.<h4>Objective and methods</h4>We performed a meta-analysis to elucidate the association between the STK39 rs3754777 polymorphism (or proxy) and hypertension. Published literature from PubMed and Embase databases were retrieved and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model.<h4>Results</h4>Using appropriate inclusion/exclusion criteria, we identified 10 studies that included 21, 863 hypertensive cases and 24, 480 controls from different ethnicities. The meta-analysis showed a significant association of STK39 rs3754777 variant with hypertension (OR = 1.10, 95%CI = 1.06-1.15, p = 7.95 × 10(-6)). Further subgroup analysis by ethnicity suggested that the association was significant in Europeans (OR = 1.08, 95% CI = 1.03-1.14, p = 0.002) and in East Asians (OR = 1.16, 95%CI = 1.07-1.25, p = 4.34 × 10(-4)), but not in Africans (OR = 1.01, 95%CI 0.80-1.27, p = 0.932). We further confirmed the positive association by sensitivity analysis. No publication bias was detected (Begg's test, p = 0.721; Egger's test, p = 0.744).<h4>Conclusions</h4>The present meta-analysis confirms the significant association of STK39 polymorphism with susceptibility to hypertension in Europeans and East Asians. Future studies should include gene-gene and gene-environment interactions to investigate the identified association.Bo XiMan ChenGiriraj R ChandakYue ShenLi YanJuan HeSi-Hua MouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59584 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bo Xi Man Chen Giriraj R Chandak Yue Shen Li Yan Juan He Si-Hua Mou STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.
description	<h4>Background</h4>A recent genome-wide association study identified STK39as a candidate gene for blood pressure (BP) in Europeans. Subsequently, several studies have attempted to replicate the association across different ethnic populations. However, the results have been inconsistent.<h4>Objective and methods</h4>We performed a meta-analysis to elucidate the association between the STK39 rs3754777 polymorphism (or proxy) and hypertension. Published literature from PubMed and Embase databases were retrieved and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects model.<h4>Results</h4>Using appropriate inclusion/exclusion criteria, we identified 10 studies that included 21, 863 hypertensive cases and 24, 480 controls from different ethnicities. The meta-analysis showed a significant association of STK39 rs3754777 variant with hypertension (OR = 1.10, 95%CI = 1.06-1.15, p = 7.95 × 10(-6)). Further subgroup analysis by ethnicity suggested that the association was significant in Europeans (OR = 1.08, 95% CI = 1.03-1.14, p = 0.002) and in East Asians (OR = 1.16, 95%CI = 1.07-1.25, p = 4.34 × 10(-4)), but not in Africans (OR = 1.01, 95%CI 0.80-1.27, p = 0.932). We further confirmed the positive association by sensitivity analysis. No publication bias was detected (Begg's test, p = 0.721; Egger's test, p = 0.744).<h4>Conclusions</h4>The present meta-analysis confirms the significant association of STK39 polymorphism with susceptibility to hypertension in Europeans and East Asians. Future studies should include gene-gene and gene-environment interactions to investigate the identified association.
format	article
author	Bo Xi Man Chen Giriraj R Chandak Yue Shen Li Yan Juan He Si-Hua Mou
author_facet	Bo Xi Man Chen Giriraj R Chandak Yue Shen Li Yan Juan He Si-Hua Mou
author_sort	Bo Xi
title	STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.
title_short	STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.
title_full	STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.
title_fullStr	STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.
title_full_unstemmed	STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.
title_sort	stk39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/e9650553bd624fd881cd7118d794ea4a
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STK39 polymorphism is associated with essential hypertension: a systematic review and meta-analysis.

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