Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles

Abstract Anthropic nanoparticles (NP) are increasingly produced and emitted, with accompanying concerns for human health. Currently there is no global understanding as to the exact mechanistics of NP toxicity, as the traditional nanotoxicological approaches only provide a restricted overview. To add...

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Autores principales:	Étienne Audureau, Angélique Simon-Deckers, Marie-Laure Franco-Montoya, Balasubramanyam Annangi, Ali Kermanizadeh, Jorge Boczkowski, Sophie Lanone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e9690d4d204241fcbce785e69b5faf9a
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spelling	oai:doaj.org-article:e9690d4d204241fcbce785e69b5faf9a2021-12-02T15:08:27ZSubstantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles10.1038/s41598-018-26988-z2045-2322https://doaj.org/article/e9690d4d204241fcbce785e69b5faf9a2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-26988-zhttps://doaj.org/toc/2045-2322Abstract Anthropic nanoparticles (NP) are increasingly produced and emitted, with accompanying concerns for human health. Currently there is no global understanding as to the exact mechanistics of NP toxicity, as the traditional nanotoxicological approaches only provide a restricted overview. To address this issue, we performed an in-depth transcriptomic analysis of human macrophages exposed to a panel of welding-related metal oxide NP that we previously identified in welders lungs (Fe2O3, Fe3O4, MnFe2O4 and CrOOH NP). Utilizing the specified analysis criteria (\|fold change\| ≥1.5, p ≤ 0.001), a total of 2164 genes were identified to be differentially expressed after THP-1 macrophage exposure to the different NP. Performing Gene Ontology enrichment analysis, for cellular content, biological processes and Swiss-Prot/Protein Information Resource keywords the data show for the first time a profound modification of gene differential expression in response to the different NP, among which MnFe2O4 NP were the most potent to induce THP-1 macrophage activation. The transcriptomic analysis utilized in the study, provides novel insights into mechanisms that could contribute to NP-induced adverse effects and support the need for widened approaches to supplement existing knowledge of the processes underlying NP toxicity which would have not been possible using traditional nanotoxicological studies.Étienne AudureauAngélique Simon-DeckersMarie-Laure Franco-MontoyaBalasubramanyam AnnangiAli KermanizadehJorge BoczkowskiSophie LanoneNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Étienne Audureau Angélique Simon-Deckers Marie-Laure Franco-Montoya Balasubramanyam Annangi Ali Kermanizadeh Jorge Boczkowski Sophie Lanone Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles
description	Abstract Anthropic nanoparticles (NP) are increasingly produced and emitted, with accompanying concerns for human health. Currently there is no global understanding as to the exact mechanistics of NP toxicity, as the traditional nanotoxicological approaches only provide a restricted overview. To address this issue, we performed an in-depth transcriptomic analysis of human macrophages exposed to a panel of welding-related metal oxide NP that we previously identified in welders lungs (Fe2O3, Fe3O4, MnFe2O4 and CrOOH NP). Utilizing the specified analysis criteria (\|fold change\| ≥1.5, p ≤ 0.001), a total of 2164 genes were identified to be differentially expressed after THP-1 macrophage exposure to the different NP. Performing Gene Ontology enrichment analysis, for cellular content, biological processes and Swiss-Prot/Protein Information Resource keywords the data show for the first time a profound modification of gene differential expression in response to the different NP, among which MnFe2O4 NP were the most potent to induce THP-1 macrophage activation. The transcriptomic analysis utilized in the study, provides novel insights into mechanisms that could contribute to NP-induced adverse effects and support the need for widened approaches to supplement existing knowledge of the processes underlying NP toxicity which would have not been possible using traditional nanotoxicological studies.
format	article
author	Étienne Audureau Angélique Simon-Deckers Marie-Laure Franco-Montoya Balasubramanyam Annangi Ali Kermanizadeh Jorge Boczkowski Sophie Lanone
author_facet	Étienne Audureau Angélique Simon-Deckers Marie-Laure Franco-Montoya Balasubramanyam Annangi Ali Kermanizadeh Jorge Boczkowski Sophie Lanone
author_sort	Étienne Audureau
title	Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles
title_short	Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles
title_full	Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles
title_fullStr	Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles
title_full_unstemmed	Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles
title_sort	substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e9690d4d204241fcbce785e69b5faf9a
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Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles

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