Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells

Brain myelinating oligodendrocytes are rare and difficult to isolate, which has limited data on their development. Here the authors develop a reporter for scalable purification of human pluripotent stem cell derived oligodendrocyte lineage cells, and use this to map differentiation using single cell...

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Autores principales:	Xitiz Chamling, Alyssa Kallman, Weixiang Fang, Cynthia A. Berlinicke, Joseph L. Mertz, Prajwal Devkota, Itzy E. Morales Pantoja, Matthew D. Smith, Zhicheng Ji, Calvin Chang, Aniruddha Kaushik, Liben Chen, Katharine A. Whartenby, Peter A. Calabresi, Hai-Quan Mao, Hongkai Ji, Tza-Huei Wang, Donald J. Zack
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e96ddf8af967458184f40a76c755772f
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spelling	oai:doaj.org-article:e96ddf8af967458184f40a76c755772f2021-12-02T14:16:40ZSingle-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells10.1038/s41467-021-20892-32041-1723https://doaj.org/article/e96ddf8af967458184f40a76c755772f2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-20892-3https://doaj.org/toc/2041-1723Brain myelinating oligodendrocytes are rare and difficult to isolate, which has limited data on their development. Here the authors develop a reporter for scalable purification of human pluripotent stem cell derived oligodendrocyte lineage cells, and use this to map differentiation using single cell RNA-sequencing,Xitiz ChamlingAlyssa KallmanWeixiang FangCynthia A. BerlinickeJoseph L. MertzPrajwal DevkotaItzy E. Morales PantojaMatthew D. SmithZhicheng JiCalvin ChangAniruddha KaushikLiben ChenKatharine A. WhartenbyPeter A. CalabresiHai-Quan MaoHongkai JiTza-Huei WangDonald J. ZackNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xitiz Chamling Alyssa Kallman Weixiang Fang Cynthia A. Berlinicke Joseph L. Mertz Prajwal Devkota Itzy E. Morales Pantoja Matthew D. Smith Zhicheng Ji Calvin Chang Aniruddha Kaushik Liben Chen Katharine A. Whartenby Peter A. Calabresi Hai-Quan Mao Hongkai Ji Tza-Huei Wang Donald J. Zack Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells
description	Brain myelinating oligodendrocytes are rare and difficult to isolate, which has limited data on their development. Here the authors develop a reporter for scalable purification of human pluripotent stem cell derived oligodendrocyte lineage cells, and use this to map differentiation using single cell RNA-sequencing,
format	article
author	Xitiz Chamling Alyssa Kallman Weixiang Fang Cynthia A. Berlinicke Joseph L. Mertz Prajwal Devkota Itzy E. Morales Pantoja Matthew D. Smith Zhicheng Ji Calvin Chang Aniruddha Kaushik Liben Chen Katharine A. Whartenby Peter A. Calabresi Hai-Quan Mao Hongkai Ji Tza-Huei Wang Donald J. Zack
author_facet	Xitiz Chamling Alyssa Kallman Weixiang Fang Cynthia A. Berlinicke Joseph L. Mertz Prajwal Devkota Itzy E. Morales Pantoja Matthew D. Smith Zhicheng Ji Calvin Chang Aniruddha Kaushik Liben Chen Katharine A. Whartenby Peter A. Calabresi Hai-Quan Mao Hongkai Ji Tza-Huei Wang Donald J. Zack
author_sort	Xitiz Chamling
title	Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells
title_short	Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells
title_full	Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells
title_fullStr	Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells
title_full_unstemmed	Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells
title_sort	single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e96ddf8af967458184f40a76c755772f
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Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells

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