In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits

In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits

Majority of human long non-coding RNAs (lncRNAs) are not conserved in mouse. Here the authors identify metabolic trait-associated lncRNA genes and show a functional role of a non-conserved human lncRNA, LINC01018, in lipid metabolism using a humanized mouse model.

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Detalles Bibliográficos
Autores principales: Xiangbo Ruan, Ping Li, Yi Chen, Yu Shi, Mehdi Pirooznia, Fayaz Seifuddin, Hiroshi Suemizu, Yasuyuki Ohnishi, Nao Yoneda, Megumi Nishiwaki, James Shepherdson, Abhilash Suresh, Komudi Singh, Yonghe Ma, Cheng-fei Jiang, Haiming Cao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/e9734ba8a9b94d87bb9cd80145454700
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Descripción
Sumario:Majority of human long non-coding RNAs (lncRNAs) are not conserved in mouse. Here the authors identify metabolic trait-associated lncRNA genes and show a functional role of a non-conserved human lncRNA, LINC01018, in lipid metabolism using a humanized mouse model.

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