In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits

Majority of human long non-coding RNAs (lncRNAs) are not conserved in mouse. Here the authors identify metabolic trait-associated lncRNA genes and show a functional role of a non-conserved human lncRNA, LINC01018, in lipid metabolism using a humanized mouse model.

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Autores principales:	Xiangbo Ruan, Ping Li, Yi Chen, Yu Shi, Mehdi Pirooznia, Fayaz Seifuddin, Hiroshi Suemizu, Yasuyuki Ohnishi, Nao Yoneda, Megumi Nishiwaki, James Shepherdson, Abhilash Suresh, Komudi Singh, Yonghe Ma, Cheng-fei Jiang, Haiming Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e9734ba8a9b94d87bb9cd80145454700
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spelling	oai:doaj.org-article:e9734ba8a9b94d87bb9cd801454547002021-12-02T14:40:50ZIn vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits10.1038/s41467-019-13688-z2041-1723https://doaj.org/article/e9734ba8a9b94d87bb9cd801454547002020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13688-zhttps://doaj.org/toc/2041-1723Majority of human long non-coding RNAs (lncRNAs) are not conserved in mouse. Here the authors identify metabolic trait-associated lncRNA genes and show a functional role of a non-conserved human lncRNA, LINC01018, in lipid metabolism using a humanized mouse model.Xiangbo RuanPing LiYi ChenYu ShiMehdi PiroozniaFayaz SeifuddinHiroshi SuemizuYasuyuki OhnishiNao YonedaMegumi NishiwakiJames ShepherdsonAbhilash SureshKomudi SinghYonghe MaCheng-fei JiangHaiming CaoNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiangbo Ruan Ping Li Yi Chen Yu Shi Mehdi Pirooznia Fayaz Seifuddin Hiroshi Suemizu Yasuyuki Ohnishi Nao Yoneda Megumi Nishiwaki James Shepherdson Abhilash Suresh Komudi Singh Yonghe Ma Cheng-fei Jiang Haiming Cao In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits
description	Majority of human long non-coding RNAs (lncRNAs) are not conserved in mouse. Here the authors identify metabolic trait-associated lncRNA genes and show a functional role of a non-conserved human lncRNA, LINC01018, in lipid metabolism using a humanized mouse model.
format	article
author	Xiangbo Ruan Ping Li Yi Chen Yu Shi Mehdi Pirooznia Fayaz Seifuddin Hiroshi Suemizu Yasuyuki Ohnishi Nao Yoneda Megumi Nishiwaki James Shepherdson Abhilash Suresh Komudi Singh Yonghe Ma Cheng-fei Jiang Haiming Cao
author_facet	Xiangbo Ruan Ping Li Yi Chen Yu Shi Mehdi Pirooznia Fayaz Seifuddin Hiroshi Suemizu Yasuyuki Ohnishi Nao Yoneda Megumi Nishiwaki James Shepherdson Abhilash Suresh Komudi Singh Yonghe Ma Cheng-fei Jiang Haiming Cao
author_sort	Xiangbo Ruan
title	In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits
title_short	In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits
title_full	In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits
title_fullStr	In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits
title_full_unstemmed	In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits
title_sort	in vivo functional analysis of non-conserved human lncrnas associated with cardiometabolic traits
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e9734ba8a9b94d87bb9cd80145454700
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In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits

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