Crbn modulates calcium influx by regulating Orai1 during efferocytosis

Calcium flux must be carefully controlled during the phagocytosis of apoptotic cells (efferocytosis), although how this occurs is not fully understood. Here, the authors show that the Cereblon E3 ligase regulates Orai1 degradation and subsequently SOCE-mediated calcium influx.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hyunji Moon, Chanhyuk Min, Gayoung Kim, Deokhwan Kim, Kwanhyeong Kim, Sang-Ah Lee, Byeongjin Moon, Susumin Yang, Juyeon Lee, Seung-Joo Yang, Steve K. Cho, Gwangrog Lee, Chang Sup Lee, Chul-Seung Park, Daeho Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e974b64c64804ac5944f1149649c6f51
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e974b64c64804ac5944f1149649c6f51
record_format	dspace
spelling	oai:doaj.org-article:e974b64c64804ac5944f1149649c6f512021-12-02T14:41:23ZCrbn modulates calcium influx by regulating Orai1 during efferocytosis10.1038/s41467-020-19272-02041-1723https://doaj.org/article/e974b64c64804ac5944f1149649c6f512020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19272-0https://doaj.org/toc/2041-1723Calcium flux must be carefully controlled during the phagocytosis of apoptotic cells (efferocytosis), although how this occurs is not fully understood. Here, the authors show that the Cereblon E3 ligase regulates Orai1 degradation and subsequently SOCE-mediated calcium influx.Hyunji MoonChanhyuk MinGayoung KimDeokhwan KimKwanhyeong KimSang-Ah LeeByeongjin MoonSusumin YangJuyeon LeeSeung-Joo YangSteve K. ChoGwangrog LeeChang Sup LeeChul-Seung ParkDaeho ParkNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyunji Moon Chanhyuk Min Gayoung Kim Deokhwan Kim Kwanhyeong Kim Sang-Ah Lee Byeongjin Moon Susumin Yang Juyeon Lee Seung-Joo Yang Steve K. Cho Gwangrog Lee Chang Sup Lee Chul-Seung Park Daeho Park Crbn modulates calcium influx by regulating Orai1 during efferocytosis
description	Calcium flux must be carefully controlled during the phagocytosis of apoptotic cells (efferocytosis), although how this occurs is not fully understood. Here, the authors show that the Cereblon E3 ligase regulates Orai1 degradation and subsequently SOCE-mediated calcium influx.
format	article
author	Hyunji Moon Chanhyuk Min Gayoung Kim Deokhwan Kim Kwanhyeong Kim Sang-Ah Lee Byeongjin Moon Susumin Yang Juyeon Lee Seung-Joo Yang Steve K. Cho Gwangrog Lee Chang Sup Lee Chul-Seung Park Daeho Park
author_facet	Hyunji Moon Chanhyuk Min Gayoung Kim Deokhwan Kim Kwanhyeong Kim Sang-Ah Lee Byeongjin Moon Susumin Yang Juyeon Lee Seung-Joo Yang Steve K. Cho Gwangrog Lee Chang Sup Lee Chul-Seung Park Daeho Park
author_sort	Hyunji Moon
title	Crbn modulates calcium influx by regulating Orai1 during efferocytosis
title_short	Crbn modulates calcium influx by regulating Orai1 during efferocytosis
title_full	Crbn modulates calcium influx by regulating Orai1 during efferocytosis
title_fullStr	Crbn modulates calcium influx by regulating Orai1 during efferocytosis
title_full_unstemmed	Crbn modulates calcium influx by regulating Orai1 during efferocytosis
title_sort	crbn modulates calcium influx by regulating orai1 during efferocytosis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e974b64c64804ac5944f1149649c6f51
work_keys_str_mv	AT hyunjimoon crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT chanhyukmin crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT gayoungkim crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT deokhwankim crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT kwanhyeongkim crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT sangahlee crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT byeongjinmoon crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT susuminyang crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT juyeonlee crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT seungjooyang crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT stevekcho crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT gwangroglee crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT changsuplee crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT chulseungpark crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis AT daehopark crbnmodulatescalciuminfluxbyregulatingorai1duringefferocytosis
_version_	1718389904887513088

Crbn modulates calcium influx by regulating Orai1 during efferocytosis

Ejemplares similares